| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| PlcN | aas | HMPREF0758_1988 | HMPREF0758_2288 | Phospholipase C, phosphocholine-specific; COG: COG3511; Pfam: PF04185,PF05506; InterPro: IPR007312. | AMP-binding enzyme; Plays a role in lysophospholipid acylation. Transfers fatty acids to the 1-position via an enzyme-bound acyl-ACP intermediate in the presence of ATP and magnesium. Its physiological function is to regenerate phosphatidylethanolamine from 2-acyl-glycero-3- phosphoethanolamine (2-acyl-GPE) formed by transacylation reactions or degradation by phospholipase A1; In the C-terminal section; belongs to the ATP-dependent AMP-binding enzyme family. | 0.902 |
| PlcN | betA | HMPREF0758_1988 | HMPREF0758_4630 | Phospholipase C, phosphocholine-specific; COG: COG3511; Pfam: PF04185,PF05506; InterPro: IPR007312. | Choline dehydrogenase; Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate. | 0.800 |
| PlcN | pldA | HMPREF0758_1988 | HMPREF0758_1546 | Phospholipase C, phosphocholine-specific; COG: COG3511; Pfam: PF04185,PF05506; InterPro: IPR007312. | Phospholipase A1; Hydrolysis of phosphatidylcholine with phospholipase A2 (EC 3.1.1.4) and phospholipase A1 (EC 3.1.1.32) activities. Belongs to the phospholipase A1 family. | 0.901 |
| PlcN | psd | HMPREF0758_1988 | HMPREF0758_0875 | Phospholipase C, phosphocholine-specific; COG: COG3511; Pfam: PF04185,PF05506; InterPro: IPR007312. | Phosphatidylserine decarboxylase; Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer). | 0.900 |
| PlcN | pssA | HMPREF0758_1988 | HMPREF0758_2373 | Phospholipase C, phosphocholine-specific; COG: COG3511; Pfam: PF04185,PF05506; InterPro: IPR007312. | Phospholipase D domain protein; COG: COG1502; Pfam: PF00614. | 0.817 |
| aas | PlcN | HMPREF0758_2288 | HMPREF0758_1988 | AMP-binding enzyme; Plays a role in lysophospholipid acylation. Transfers fatty acids to the 1-position via an enzyme-bound acyl-ACP intermediate in the presence of ATP and magnesium. Its physiological function is to regenerate phosphatidylethanolamine from 2-acyl-glycero-3- phosphoethanolamine (2-acyl-GPE) formed by transacylation reactions or degradation by phospholipase A1; In the C-terminal section; belongs to the ATP-dependent AMP-binding enzyme family. | Phospholipase C, phosphocholine-specific; COG: COG3511; Pfam: PF04185,PF05506; InterPro: IPR007312. | 0.902 |
| aas | betA | HMPREF0758_2288 | HMPREF0758_4630 | AMP-binding enzyme; Plays a role in lysophospholipid acylation. Transfers fatty acids to the 1-position via an enzyme-bound acyl-ACP intermediate in the presence of ATP and magnesium. Its physiological function is to regenerate phosphatidylethanolamine from 2-acyl-glycero-3- phosphoethanolamine (2-acyl-GPE) formed by transacylation reactions or degradation by phospholipase A1; In the C-terminal section; belongs to the ATP-dependent AMP-binding enzyme family. | Choline dehydrogenase; Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate. | 0.813 |
| aas | gpsA | HMPREF0758_2288 | HMPREF0758_1236 | AMP-binding enzyme; Plays a role in lysophospholipid acylation. Transfers fatty acids to the 1-position via an enzyme-bound acyl-ACP intermediate in the presence of ATP and magnesium. Its physiological function is to regenerate phosphatidylethanolamine from 2-acyl-glycero-3- phosphoethanolamine (2-acyl-GPE) formed by transacylation reactions or degradation by phospholipase A1; In the C-terminal section; belongs to the ATP-dependent AMP-binding enzyme family. | Putative glycerol-3-phosphate dehydrogenase [NAD(P)+]; COG: COG0240; Pfam: PF01210,PF07479; InterPro: IPR006168; Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family. | 0.465 |
| aas | pgsA | HMPREF0758_2288 | HMPREF0758_4263 | AMP-binding enzyme; Plays a role in lysophospholipid acylation. Transfers fatty acids to the 1-position via an enzyme-bound acyl-ACP intermediate in the presence of ATP and magnesium. Its physiological function is to regenerate phosphatidylethanolamine from 2-acyl-glycero-3- phosphoethanolamine (2-acyl-GPE) formed by transacylation reactions or degradation by phospholipase A1; In the C-terminal section; belongs to the ATP-dependent AMP-binding enzyme family. | CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase; This protein catalyzes the committed step to the synthesis of the acidic phospholipids; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. | 0.540 |
| aas | pldA | HMPREF0758_2288 | HMPREF0758_1546 | AMP-binding enzyme; Plays a role in lysophospholipid acylation. Transfers fatty acids to the 1-position via an enzyme-bound acyl-ACP intermediate in the presence of ATP and magnesium. Its physiological function is to regenerate phosphatidylethanolamine from 2-acyl-glycero-3- phosphoethanolamine (2-acyl-GPE) formed by transacylation reactions or degradation by phospholipase A1; In the C-terminal section; belongs to the ATP-dependent AMP-binding enzyme family. | Phospholipase A1; Hydrolysis of phosphatidylcholine with phospholipase A2 (EC 3.1.1.4) and phospholipase A1 (EC 3.1.1.32) activities. Belongs to the phospholipase A1 family. | 0.918 |
| aas | psd | HMPREF0758_2288 | HMPREF0758_0875 | AMP-binding enzyme; Plays a role in lysophospholipid acylation. Transfers fatty acids to the 1-position via an enzyme-bound acyl-ACP intermediate in the presence of ATP and magnesium. Its physiological function is to regenerate phosphatidylethanolamine from 2-acyl-glycero-3- phosphoethanolamine (2-acyl-GPE) formed by transacylation reactions or degradation by phospholipase A1; In the C-terminal section; belongs to the ATP-dependent AMP-binding enzyme family. | Phosphatidylserine decarboxylase; Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer). | 0.939 |
| aas | pssA | HMPREF0758_2288 | HMPREF0758_2373 | AMP-binding enzyme; Plays a role in lysophospholipid acylation. Transfers fatty acids to the 1-position via an enzyme-bound acyl-ACP intermediate in the presence of ATP and magnesium. Its physiological function is to regenerate phosphatidylethanolamine from 2-acyl-glycero-3- phosphoethanolamine (2-acyl-GPE) formed by transacylation reactions or degradation by phospholipase A1; In the C-terminal section; belongs to the ATP-dependent AMP-binding enzyme family. | Phospholipase D domain protein; COG: COG1502; Pfam: PF00614. | 0.843 |
| betA | PlcN | HMPREF0758_4630 | HMPREF0758_1988 | Choline dehydrogenase; Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate. | Phospholipase C, phosphocholine-specific; COG: COG3511; Pfam: PF04185,PF05506; InterPro: IPR007312. | 0.800 |
| betA | aas | HMPREF0758_4630 | HMPREF0758_2288 | Choline dehydrogenase; Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate. | AMP-binding enzyme; Plays a role in lysophospholipid acylation. Transfers fatty acids to the 1-position via an enzyme-bound acyl-ACP intermediate in the presence of ATP and magnesium. Its physiological function is to regenerate phosphatidylethanolamine from 2-acyl-glycero-3- phosphoethanolamine (2-acyl-GPE) formed by transacylation reactions or degradation by phospholipase A1; In the C-terminal section; belongs to the ATP-dependent AMP-binding enzyme family. | 0.813 |
| betA | pldA | HMPREF0758_4630 | HMPREF0758_1546 | Choline dehydrogenase; Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate. | Phospholipase A1; Hydrolysis of phosphatidylcholine with phospholipase A2 (EC 3.1.1.4) and phospholipase A1 (EC 3.1.1.32) activities. Belongs to the phospholipase A1 family. | 0.822 |
| betA | psd | HMPREF0758_4630 | HMPREF0758_0875 | Choline dehydrogenase; Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate. | Phosphatidylserine decarboxylase; Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer). | 0.800 |
| bspA | psd | HMPREF0758_0876 | HMPREF0758_0875 | Transporter, small conductance mechanosensitive ion channel MscS family protein; COG: COG3264; Pfam: PF00924; InterPro: IPR006685. | Phosphatidylserine decarboxylase; Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer). | 0.801 |
| bspA | pssA | HMPREF0758_0876 | HMPREF0758_2373 | Transporter, small conductance mechanosensitive ion channel MscS family protein; COG: COG3264; Pfam: PF00924; InterPro: IPR006685. | Phospholipase D domain protein; COG: COG1502; Pfam: PF00614. | 0.599 |
| bspA | rsgA | HMPREF0758_0876 | HMPREF0758_0874 | Transporter, small conductance mechanosensitive ion channel MscS family protein; COG: COG3264; Pfam: PF00924; InterPro: IPR006685. | Ribosome small subunit-dependent GTPase A; One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit; Belongs to the TRAFAC class YlqF/YawG GTPase family. RsgA subfamily. | 0.626 |
| gpsA | aas | HMPREF0758_1236 | HMPREF0758_2288 | Putative glycerol-3-phosphate dehydrogenase [NAD(P)+]; COG: COG0240; Pfam: PF01210,PF07479; InterPro: IPR006168; Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family. | AMP-binding enzyme; Plays a role in lysophospholipid acylation. Transfers fatty acids to the 1-position via an enzyme-bound acyl-ACP intermediate in the presence of ATP and magnesium. Its physiological function is to regenerate phosphatidylethanolamine from 2-acyl-glycero-3- phosphoethanolamine (2-acyl-GPE) formed by transacylation reactions or degradation by phospholipase A1; In the C-terminal section; belongs to the ATP-dependent AMP-binding enzyme family. | 0.465 |