| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| EFE97319.1 | codA | HMPREF0758_1013 | HMPREF0758_1011 | Hypothetical protein. | Amidohydrolase family protein; COG: COG0402; Pfam: PF07969; InterPro: IPR013108. | 0.568 |
| EFE97319.1 | codB | HMPREF0758_1013 | HMPREF0758_1012 | Hypothetical protein. | Cytosine permease; COG: COG1457; Pfam: PF02133; InterPro: IPR001248. | 0.568 |
| carA | carB | HMPREF0758_0566 | HMPREF0758_0565 | Carbamoyl-phosphate synthase, small subunit; COG: COG0505; Pfam: PF00988,PF00117; InterPro: IPR006274; Belongs to the CarA family. | Carbamoyl-phosphate synthase, large subunit; COG: COG0458; Pfam: PF00289,PF02786,PF02787,PF02142; InterPro: IPR006275; Belongs to the CarB family. | 0.999 |
| carA | codB | HMPREF0758_0566 | HMPREF0758_1012 | Carbamoyl-phosphate synthase, small subunit; COG: COG0505; Pfam: PF00988,PF00117; InterPro: IPR006274; Belongs to the CarA family. | Cytosine permease; COG: COG1457; Pfam: PF02133; InterPro: IPR001248. | 0.543 |
| carA | pyrB | HMPREF0758_0566 | HMPREF0758_0752 | Carbamoyl-phosphate synthase, small subunit; COG: COG0505; Pfam: PF00988,PF00117; InterPro: IPR006274; Belongs to the CarA family. | Aspartate carbamoyltransferase; COG: COG0540; Pfam: PF02729,PF00185; InterPro: IPR002082; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family. | 0.999 |
| carA | pyrC | HMPREF0758_0566 | HMPREF0758_4197 | Carbamoyl-phosphate synthase, small subunit; COG: COG0505; Pfam: PF00988,PF00117; InterPro: IPR006274; Belongs to the CarA family. | Dihydroorotase, homodimeric type; Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate. | 0.619 |
| carA | pyrD | HMPREF0758_0566 | HMPREF0758_4352 | Carbamoyl-phosphate synthase, small subunit; COG: COG0505; Pfam: PF00988,PF00117; InterPro: IPR006274; Belongs to the CarA family. | Dihydroorotate oxidase; Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor; Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily. | 0.958 |
| carA | pyrI | HMPREF0758_0566 | HMPREF0758_0753 | Carbamoyl-phosphate synthase, small subunit; COG: COG0505; Pfam: PF00988,PF00117; InterPro: IPR006274; Belongs to the CarA family. | Aspartate carbamoyltransferase, regulatory subunit; Involved in allosteric regulation of aspartate carbamoyltransferase. | 0.959 |
| carB | carA | HMPREF0758_0565 | HMPREF0758_0566 | Carbamoyl-phosphate synthase, large subunit; COG: COG0458; Pfam: PF00289,PF02786,PF02787,PF02142; InterPro: IPR006275; Belongs to the CarB family. | Carbamoyl-phosphate synthase, small subunit; COG: COG0505; Pfam: PF00988,PF00117; InterPro: IPR006274; Belongs to the CarA family. | 0.999 |
| carB | codB | HMPREF0758_0565 | HMPREF0758_1012 | Carbamoyl-phosphate synthase, large subunit; COG: COG0458; Pfam: PF00289,PF02786,PF02787,PF02142; InterPro: IPR006275; Belongs to the CarB family. | Cytosine permease; COG: COG1457; Pfam: PF02133; InterPro: IPR001248. | 0.548 |
| carB | pyrB | HMPREF0758_0565 | HMPREF0758_0752 | Carbamoyl-phosphate synthase, large subunit; COG: COG0458; Pfam: PF00289,PF02786,PF02787,PF02142; InterPro: IPR006275; Belongs to the CarB family. | Aspartate carbamoyltransferase; COG: COG0540; Pfam: PF02729,PF00185; InterPro: IPR002082; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family. | 0.999 |
| carB | pyrC | HMPREF0758_0565 | HMPREF0758_4197 | Carbamoyl-phosphate synthase, large subunit; COG: COG0458; Pfam: PF00289,PF02786,PF02787,PF02142; InterPro: IPR006275; Belongs to the CarB family. | Dihydroorotase, homodimeric type; Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate. | 0.664 |
| carB | pyrD | HMPREF0758_0565 | HMPREF0758_4352 | Carbamoyl-phosphate synthase, large subunit; COG: COG0458; Pfam: PF00289,PF02786,PF02787,PF02142; InterPro: IPR006275; Belongs to the CarB family. | Dihydroorotate oxidase; Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor; Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily. | 0.967 |
| carB | pyrI | HMPREF0758_0565 | HMPREF0758_0753 | Carbamoyl-phosphate synthase, large subunit; COG: COG0458; Pfam: PF00289,PF02786,PF02787,PF02142; InterPro: IPR006275; Belongs to the CarB family. | Aspartate carbamoyltransferase, regulatory subunit; Involved in allosteric regulation of aspartate carbamoyltransferase. | 0.966 |
| codA | EFE97319.1 | HMPREF0758_1011 | HMPREF0758_1013 | Amidohydrolase family protein; COG: COG0402; Pfam: PF07969; InterPro: IPR013108. | Hypothetical protein. | 0.568 |
| codA | codB | HMPREF0758_1011 | HMPREF0758_1012 | Amidohydrolase family protein; COG: COG0402; Pfam: PF07969; InterPro: IPR013108. | Cytosine permease; COG: COG1457; Pfam: PF02133; InterPro: IPR001248. | 0.967 |
| codB | EFE97319.1 | HMPREF0758_1012 | HMPREF0758_1013 | Cytosine permease; COG: COG1457; Pfam: PF02133; InterPro: IPR001248. | Hypothetical protein. | 0.568 |
| codB | carA | HMPREF0758_1012 | HMPREF0758_0566 | Cytosine permease; COG: COG1457; Pfam: PF02133; InterPro: IPR001248. | Carbamoyl-phosphate synthase, small subunit; COG: COG0505; Pfam: PF00988,PF00117; InterPro: IPR006274; Belongs to the CarA family. | 0.543 |
| codB | carB | HMPREF0758_1012 | HMPREF0758_0565 | Cytosine permease; COG: COG1457; Pfam: PF02133; InterPro: IPR001248. | Carbamoyl-phosphate synthase, large subunit; COG: COG0458; Pfam: PF00289,PF02786,PF02787,PF02142; InterPro: IPR006275; Belongs to the CarB family. | 0.548 |
| codB | codA | HMPREF0758_1012 | HMPREF0758_1011 | Cytosine permease; COG: COG1457; Pfam: PF02133; InterPro: IPR001248. | Amidohydrolase family protein; COG: COG0402; Pfam: PF07969; InterPro: IPR013108. | 0.967 |