| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| cobA-2 | ndoA | HMPREF0758_1017 | HMPREF0758_2180 | uroporphyrinogen-III C-methyltransferase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. Belongs to the precorrin methyltransferase family. In the N-terminal section; belongs to the precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase family. | Rieske [2Fe-2S] domain protein; COG: COG2146; Pfam: PF00355; InterPro: IPR005806. | 0.692 |
| cobA-2 | nirB | HMPREF0758_1017 | HMPREF0758_1014 | uroporphyrinogen-III C-methyltransferase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. Belongs to the precorrin methyltransferase family. In the N-terminal section; belongs to the precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase family. | Nitrite reductase [NAD(P)H], large subunit; COG: COG1251; Pfam: PF07992,PF00070,PF04324,PF03460,PF01077; InterPro: IPR012744; overlaps another CDS with the same product name; Belongs to the nitrite and sulfite reductase 4Fe-4S domain family. | 0.766 |
| cobA-2 | nirB-2 | HMPREF0758_1017 | HMPREF0758_3251 | uroporphyrinogen-III C-methyltransferase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. Belongs to the precorrin methyltransferase family. In the N-terminal section; belongs to the precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase family. | Nitrite reductase [NAD(P)H], large subunit; COG: COG1251; Pfam: PF07992,PF00070,PF04324,PF03460,PF01077; InterPro: IPR012744; Belongs to the nitrite and sulfite reductase 4Fe-4S domain family. | 0.900 |
| cobA-2 | nirC | HMPREF0758_1017 | HMPREF0758_1016 | uroporphyrinogen-III C-methyltransferase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. Belongs to the precorrin methyltransferase family. In the N-terminal section; belongs to the precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase family. | Nitrite transporter NirC; COG: COG2116; Pfam: PF01226; InterPro: IPR000292. | 0.786 |
| cobA-2 | nirD | HMPREF0758_1017 | HMPREF0758_1015 | uroporphyrinogen-III C-methyltransferase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. Belongs to the precorrin methyltransferase family. In the N-terminal section; belongs to the precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase family. | Nitrite reductase [NAD(P)H], small subunit; COG: COG2146; InterPro: IPR012748; overlaps another CDS with the same product name. | 0.843 |
| cobA-2 | rubA | HMPREF0758_1017 | HMPREF0758_0910 | uroporphyrinogen-III C-methyltransferase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. Belongs to the precorrin methyltransferase family. In the N-terminal section; belongs to the precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase family. | Rubredoxin; COG: COG1773; Pfam: PF00301; InterPro: IPR004039; Belongs to the rubredoxin family. | 0.463 |
| hcp | hmpA | HMPREF0758_4465 | HMPREF0758_2477 | Hydroxylamine reductase; Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O. | Globin; Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress; Belongs to the globin family. Two-domain flavohemoproteins subfamily. | 0.794 |
| hcp | ndoA | HMPREF0758_4465 | HMPREF0758_2180 | Hydroxylamine reductase; Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O. | Rieske [2Fe-2S] domain protein; COG: COG2146; Pfam: PF00355; InterPro: IPR005806. | 0.507 |
| hcp | nirB | HMPREF0758_4465 | HMPREF0758_1014 | Hydroxylamine reductase; Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O. | Nitrite reductase [NAD(P)H], large subunit; COG: COG1251; Pfam: PF07992,PF00070,PF04324,PF03460,PF01077; InterPro: IPR012744; overlaps another CDS with the same product name; Belongs to the nitrite and sulfite reductase 4Fe-4S domain family. | 0.604 |
| hcp | nirB-2 | HMPREF0758_4465 | HMPREF0758_3251 | Hydroxylamine reductase; Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O. | Nitrite reductase [NAD(P)H], large subunit; COG: COG1251; Pfam: PF07992,PF00070,PF04324,PF03460,PF01077; InterPro: IPR012744; Belongs to the nitrite and sulfite reductase 4Fe-4S domain family. | 0.994 |
| hcp | nirD | HMPREF0758_4465 | HMPREF0758_1015 | Hydroxylamine reductase; Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O. | Nitrite reductase [NAD(P)H], small subunit; COG: COG2146; InterPro: IPR012748; overlaps another CDS with the same product name. | 0.948 |
| hcp | rubA | HMPREF0758_4465 | HMPREF0758_0910 | Hydroxylamine reductase; Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O. | Rubredoxin; COG: COG1773; Pfam: PF00301; InterPro: IPR004039; Belongs to the rubredoxin family. | 0.794 |
| hmpA | hcp | HMPREF0758_2477 | HMPREF0758_4465 | Globin; Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress; Belongs to the globin family. Two-domain flavohemoproteins subfamily. | Hydroxylamine reductase; Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O. | 0.794 |
| hmpA | nasA | HMPREF0758_2477 | HMPREF0758_3252 | Globin; Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress; Belongs to the globin family. Two-domain flavohemoproteins subfamily. | Molybdopterin oxidoreductase; COG: COG0243; Pfam: PF04879,PF00384,PF01568,PF04324; InterPro: IPR006656; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. NasA/NapA/NarB subfamily. | 0.494 |
| hmpA | nirB | HMPREF0758_2477 | HMPREF0758_1014 | Globin; Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress; Belongs to the globin family. Two-domain flavohemoproteins subfamily. | Nitrite reductase [NAD(P)H], large subunit; COG: COG1251; Pfam: PF07992,PF00070,PF04324,PF03460,PF01077; InterPro: IPR012744; overlaps another CDS with the same product name; Belongs to the nitrite and sulfite reductase 4Fe-4S domain family. | 0.668 |
| hmpA | nirB-2 | HMPREF0758_2477 | HMPREF0758_3251 | Globin; Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress; Belongs to the globin family. Two-domain flavohemoproteins subfamily. | Nitrite reductase [NAD(P)H], large subunit; COG: COG1251; Pfam: PF07992,PF00070,PF04324,PF03460,PF01077; InterPro: IPR012744; Belongs to the nitrite and sulfite reductase 4Fe-4S domain family. | 0.784 |
| hmpA | rubA | HMPREF0758_2477 | HMPREF0758_0910 | Globin; Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress; Belongs to the globin family. Two-domain flavohemoproteins subfamily. | Rubredoxin; COG: COG1773; Pfam: PF00301; InterPro: IPR004039; Belongs to the rubredoxin family. | 0.784 |
| nasA | hmpA | HMPREF0758_3252 | HMPREF0758_2477 | Molybdopterin oxidoreductase; COG: COG0243; Pfam: PF04879,PF00384,PF01568,PF04324; InterPro: IPR006656; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. NasA/NapA/NarB subfamily. | Globin; Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress; Belongs to the globin family. Two-domain flavohemoproteins subfamily. | 0.494 |
| nasA | ndoA | HMPREF0758_3252 | HMPREF0758_2180 | Molybdopterin oxidoreductase; COG: COG0243; Pfam: PF04879,PF00384,PF01568,PF04324; InterPro: IPR006656; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. NasA/NapA/NarB subfamily. | Rieske [2Fe-2S] domain protein; COG: COG2146; Pfam: PF00355; InterPro: IPR005806. | 0.466 |
| nasA | nirB | HMPREF0758_3252 | HMPREF0758_1014 | Molybdopterin oxidoreductase; COG: COG0243; Pfam: PF04879,PF00384,PF01568,PF04324; InterPro: IPR006656; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. NasA/NapA/NarB subfamily. | Nitrite reductase [NAD(P)H], large subunit; COG: COG1251; Pfam: PF07992,PF00070,PF04324,PF03460,PF01077; InterPro: IPR012744; overlaps another CDS with the same product name; Belongs to the nitrite and sulfite reductase 4Fe-4S domain family. | 0.639 |