| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| EFE97319.1 | cobA-2 | HMPREF0758_1013 | HMPREF0758_1017 | Hypothetical protein. | uroporphyrinogen-III C-methyltransferase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. Belongs to the precorrin methyltransferase family. In the N-terminal section; belongs to the precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase family. | 0.403 |
| EFE97319.1 | nirB | HMPREF0758_1013 | HMPREF0758_1014 | Hypothetical protein. | Nitrite reductase [NAD(P)H], large subunit; COG: COG1251; Pfam: PF07992,PF00070,PF04324,PF03460,PF01077; InterPro: IPR012744; overlaps another CDS with the same product name; Belongs to the nitrite and sulfite reductase 4Fe-4S domain family. | 0.590 |
| EFE97319.1 | nirC | HMPREF0758_1013 | HMPREF0758_1016 | Hypothetical protein. | Nitrite transporter NirC; COG: COG2116; Pfam: PF01226; InterPro: IPR000292. | 0.490 |
| EFE97319.1 | nirD | HMPREF0758_1013 | HMPREF0758_1015 | Hypothetical protein. | Nitrite reductase [NAD(P)H], small subunit; COG: COG2146; InterPro: IPR012748; overlaps another CDS with the same product name. | 0.590 |
| cah | cah-2 | HMPREF0758_0917 | HMPREF0758_2031 | Carbonate dehydratase; Reversible hydration of carbon dioxide. Belongs to the beta-class carbonic anhydrase family. | Carbonate dehydratase; COG: COG0288; Pfam: PF00484; InterPro: IPR001765. | 0.921 |
| cah | cah-3 | HMPREF0758_0917 | HMPREF0758_2152 | Carbonate dehydratase; Reversible hydration of carbon dioxide. Belongs to the beta-class carbonic anhydrase family. | Carbonate dehydratase; Reversible hydration of carbon dioxide. Belongs to the beta-class carbonic anhydrase family. | 0.910 |
| cah | nirC | HMPREF0758_0917 | HMPREF0758_1016 | Carbonate dehydratase; Reversible hydration of carbon dioxide. Belongs to the beta-class carbonic anhydrase family. | Nitrite transporter NirC; COG: COG2116; Pfam: PF01226; InterPro: IPR000292. | 0.535 |
| cah-2 | cah | HMPREF0758_2031 | HMPREF0758_0917 | Carbonate dehydratase; COG: COG0288; Pfam: PF00484; InterPro: IPR001765. | Carbonate dehydratase; Reversible hydration of carbon dioxide. Belongs to the beta-class carbonic anhydrase family. | 0.921 |
| cah-2 | cah-3 | HMPREF0758_2031 | HMPREF0758_2152 | Carbonate dehydratase; COG: COG0288; Pfam: PF00484; InterPro: IPR001765. | Carbonate dehydratase; Reversible hydration of carbon dioxide. Belongs to the beta-class carbonic anhydrase family. | 0.916 |
| cah-2 | nirC | HMPREF0758_2031 | HMPREF0758_1016 | Carbonate dehydratase; COG: COG0288; Pfam: PF00484; InterPro: IPR001765. | Nitrite transporter NirC; COG: COG2116; Pfam: PF01226; InterPro: IPR000292. | 0.535 |
| cah-3 | cah | HMPREF0758_2152 | HMPREF0758_0917 | Carbonate dehydratase; Reversible hydration of carbon dioxide. Belongs to the beta-class carbonic anhydrase family. | Carbonate dehydratase; Reversible hydration of carbon dioxide. Belongs to the beta-class carbonic anhydrase family. | 0.910 |
| cah-3 | cah-2 | HMPREF0758_2152 | HMPREF0758_2031 | Carbonate dehydratase; Reversible hydration of carbon dioxide. Belongs to the beta-class carbonic anhydrase family. | Carbonate dehydratase; COG: COG0288; Pfam: PF00484; InterPro: IPR001765. | 0.916 |
| cah-3 | nirC | HMPREF0758_2152 | HMPREF0758_1016 | Carbonate dehydratase; Reversible hydration of carbon dioxide. Belongs to the beta-class carbonic anhydrase family. | Nitrite transporter NirC; COG: COG2116; Pfam: PF01226; InterPro: IPR000292. | 0.535 |
| cobA-2 | EFE97319.1 | HMPREF0758_1017 | HMPREF0758_1013 | uroporphyrinogen-III C-methyltransferase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. Belongs to the precorrin methyltransferase family. In the N-terminal section; belongs to the precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase family. | Hypothetical protein. | 0.403 |
| cobA-2 | cobA-3 | HMPREF0758_1017 | HMPREF0758_3253 | uroporphyrinogen-III C-methyltransferase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. Belongs to the precorrin methyltransferase family. In the N-terminal section; belongs to the precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase family. | uroporphyrinogen-III C-methyltransferase; COG: COG0007; Pfam: PF00590; InterPro: IPR006366; Belongs to the precorrin methyltransferase family. | 0.985 |
| cobA-2 | gltB | HMPREF0758_1017 | HMPREF0758_1877 | uroporphyrinogen-III C-methyltransferase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. Belongs to the precorrin methyltransferase family. In the N-terminal section; belongs to the precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase family. | Class II glutamine amidotransferase; COG: COG0069; Pfam: PF00310,PF04898,PF01645,PF01493; InterPro: IPR013785. | 0.516 |
| cobA-2 | nirB | HMPREF0758_1017 | HMPREF0758_1014 | uroporphyrinogen-III C-methyltransferase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. Belongs to the precorrin methyltransferase family. In the N-terminal section; belongs to the precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase family. | Nitrite reductase [NAD(P)H], large subunit; COG: COG1251; Pfam: PF07992,PF00070,PF04324,PF03460,PF01077; InterPro: IPR012744; overlaps another CDS with the same product name; Belongs to the nitrite and sulfite reductase 4Fe-4S domain family. | 0.766 |
| cobA-2 | nirB-2 | HMPREF0758_1017 | HMPREF0758_3251 | uroporphyrinogen-III C-methyltransferase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. Belongs to the precorrin methyltransferase family. In the N-terminal section; belongs to the precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase family. | Nitrite reductase [NAD(P)H], large subunit; COG: COG1251; Pfam: PF07992,PF00070,PF04324,PF03460,PF01077; InterPro: IPR012744; Belongs to the nitrite and sulfite reductase 4Fe-4S domain family. | 0.900 |
| cobA-2 | nirC | HMPREF0758_1017 | HMPREF0758_1016 | uroporphyrinogen-III C-methyltransferase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. Belongs to the precorrin methyltransferase family. In the N-terminal section; belongs to the precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase family. | Nitrite transporter NirC; COG: COG2116; Pfam: PF01226; InterPro: IPR000292. | 0.786 |
| cobA-2 | nirD | HMPREF0758_1017 | HMPREF0758_1015 | uroporphyrinogen-III C-methyltransferase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. Belongs to the precorrin methyltransferase family. In the N-terminal section; belongs to the precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase family. | Nitrite reductase [NAD(P)H], small subunit; COG: COG2146; InterPro: IPR012748; overlaps another CDS with the same product name. | 0.843 |