| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| birA | cueR | HMPREF0758_1652 | HMPREF0758_0140 | biotin--[acetyl-CoA-carboxylase] ligase; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio-5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon. | Cu(I)-responsive transcriptional regulator; COG: COG0789; Pfam: PF00376,PF09278; InterPro: IPR011789. | 0.420 |
| birA | nudE | HMPREF0758_1652 | HMPREF0758_1032 | biotin--[acetyl-CoA-carboxylase] ligase; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio-5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon. | Hydrolase, NUDIX family; COG: COG0494; Pfam: PF00293; InterPro: IPR000086. | 0.550 |
| birA | nudF | HMPREF0758_1652 | HMPREF0758_1956 | biotin--[acetyl-CoA-carboxylase] ligase; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio-5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon. | ADP-ribose pyrophosphatase; COG: COG0494; Pfam: PF00293; InterPro: IPR000086. | 0.550 |
| birA | prs | HMPREF0758_1652 | HMPREF0758_3388 | biotin--[acetyl-CoA-carboxylase] ligase; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio-5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon. | Ribose-phosphate diphosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. | 0.431 |
| birA | soxR2 | HMPREF0758_1652 | HMPREF0758_4057 | biotin--[acetyl-CoA-carboxylase] ligase; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio-5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon. | Transcriptional regulator, MerR family; COG: COG0789; Pfam: PF00376,PF09278; InterPro: IPR000551. | 0.420 |
| cueR | birA | HMPREF0758_0140 | HMPREF0758_1652 | Cu(I)-responsive transcriptional regulator; COG: COG0789; Pfam: PF00376,PF09278; InterPro: IPR011789. | biotin--[acetyl-CoA-carboxylase] ligase; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio-5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon. | 0.420 |
| cueR | nudE | HMPREF0758_0140 | HMPREF0758_1032 | Cu(I)-responsive transcriptional regulator; COG: COG0789; Pfam: PF00376,PF09278; InterPro: IPR011789. | Hydrolase, NUDIX family; COG: COG0494; Pfam: PF00293; InterPro: IPR000086. | 0.518 |
| deoB | nudE | HMPREF0758_0613 | HMPREF0758_1032 | Phosphopentomutase; Phosphotransfer between the C1 and C5 carbon atoms of pentose; Belongs to the phosphopentomutase family. | Hydrolase, NUDIX family; COG: COG0494; Pfam: PF00293; InterPro: IPR000086. | 0.903 |
| deoB | nudF | HMPREF0758_0613 | HMPREF0758_1956 | Phosphopentomutase; Phosphotransfer between the C1 and C5 carbon atoms of pentose; Belongs to the phosphopentomutase family. | ADP-ribose pyrophosphatase; COG: COG0494; Pfam: PF00293; InterPro: IPR000086. | 0.903 |
| deoB | pgm | HMPREF0758_0613 | HMPREF0758_4874 | Phosphopentomutase; Phosphotransfer between the C1 and C5 carbon atoms of pentose; Belongs to the phosphopentomutase family. | Phosphoglucomutase, alpha-D-glucose phosphate-specific; COG: COG0033; Pfam: PF02878,PF02879,PF02880,PF00408; InterPro: IPR005852. | 0.901 |
| deoB | prs | HMPREF0758_0613 | HMPREF0758_3388 | Phosphopentomutase; Phosphotransfer between the C1 and C5 carbon atoms of pentose; Belongs to the phosphopentomutase family. | Ribose-phosphate diphosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. | 0.917 |
| igaA | nudE | HMPREF0758_1033 | HMPREF0758_1032 | Intracellular growth attenuator protein IgaA; Pfam: PF07095; InterPro: IPR010771. | Hydrolase, NUDIX family; COG: COG0494; Pfam: PF00293; InterPro: IPR000086. | 0.475 |
| nudE | birA | HMPREF0758_1032 | HMPREF0758_1652 | Hydrolase, NUDIX family; COG: COG0494; Pfam: PF00293; InterPro: IPR000086. | biotin--[acetyl-CoA-carboxylase] ligase; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio-5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon. | 0.550 |
| nudE | cueR | HMPREF0758_1032 | HMPREF0758_0140 | Hydrolase, NUDIX family; COG: COG0494; Pfam: PF00293; InterPro: IPR000086. | Cu(I)-responsive transcriptional regulator; COG: COG0789; Pfam: PF00376,PF09278; InterPro: IPR011789. | 0.518 |
| nudE | deoB | HMPREF0758_1032 | HMPREF0758_0613 | Hydrolase, NUDIX family; COG: COG0494; Pfam: PF00293; InterPro: IPR000086. | Phosphopentomutase; Phosphotransfer between the C1 and C5 carbon atoms of pentose; Belongs to the phosphopentomutase family. | 0.903 |
| nudE | igaA | HMPREF0758_1032 | HMPREF0758_1033 | Hydrolase, NUDIX family; COG: COG0494; Pfam: PF00293; InterPro: IPR000086. | Intracellular growth attenuator protein IgaA; Pfam: PF07095; InterPro: IPR010771. | 0.475 |
| nudE | nudF | HMPREF0758_1032 | HMPREF0758_1956 | Hydrolase, NUDIX family; COG: COG0494; Pfam: PF00293; InterPro: IPR000086. | ADP-ribose pyrophosphatase; COG: COG0494; Pfam: PF00293; InterPro: IPR000086. | 0.900 |
| nudE | pgm | HMPREF0758_1032 | HMPREF0758_4874 | Hydrolase, NUDIX family; COG: COG0494; Pfam: PF00293; InterPro: IPR000086. | Phosphoglucomutase, alpha-D-glucose phosphate-specific; COG: COG0033; Pfam: PF02878,PF02879,PF02880,PF00408; InterPro: IPR005852. | 0.901 |
| nudE | prs | HMPREF0758_1032 | HMPREF0758_3388 | Hydrolase, NUDIX family; COG: COG0494; Pfam: PF00293; InterPro: IPR000086. | Ribose-phosphate diphosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. | 0.907 |
| nudE | rnr | HMPREF0758_1032 | HMPREF0758_0857 | Hydrolase, NUDIX family; COG: COG0494; Pfam: PF00293; InterPro: IPR000086. | Ribonuclease R; 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs. Belongs to the RNR ribonuclease family. RNase R subfamily. | 0.487 |