| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| hslO | hslR | HMPREF0758_1036 | HMPREF0758_1035 | Chaperonin HslO; Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress. | S4 domain protein; COG: COG1188; Pfam: PF01479; InterPro: IPR002942; Belongs to the HSP15 family. | 0.943 |
| hslO | yrfG | HMPREF0758_1036 | HMPREF0758_1034 | Chaperonin HslO; Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress. | HAD hydrolase, family IA, variant 3; COG: COG1011; Pfam: PF00702; InterPro: IPR005834. | 0.746 |
| hslR | hslO | HMPREF0758_1035 | HMPREF0758_1036 | S4 domain protein; COG: COG1188; Pfam: PF01479; InterPro: IPR002942; Belongs to the HSP15 family. | Chaperonin HslO; Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress. | 0.943 |
| hslR | macB | HMPREF0758_1035 | HMPREF0758_4460 | S4 domain protein; COG: COG1188; Pfam: PF01479; InterPro: IPR002942; Belongs to the HSP15 family. | ABC transporter, ATP-binding protein; Part of the tripartite efflux system MacAB-TolC. MacB is a non-canonical ABC transporter that contains transmembrane domains (TMD), which form a pore in the inner membrane, and an ATP-binding domain (NBD), which is responsible for energy generation. Confers resistance against macrolides. | 0.738 |
| hslR | rplM | HMPREF0758_1035 | HMPREF0758_1872 | S4 domain protein; COG: COG1188; Pfam: PF01479; InterPro: IPR002942; Belongs to the HSP15 family. | Ribosomal protein L13; This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly. | 0.719 |
| hslR | rplN | HMPREF0758_1035 | HMPREF0758_0951 | S4 domain protein; COG: COG1188; Pfam: PF01479; InterPro: IPR002942; Belongs to the HSP15 family. | Ribosomal protein L14; Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome; Belongs to the universal ribosomal protein uL14 family. | 0.721 |
| hslR | rplQ | HMPREF0758_1035 | HMPREF0758_0936 | S4 domain protein; COG: COG1188; Pfam: PF01479; InterPro: IPR002942; Belongs to the HSP15 family. | Ribosomal protein L17; COG: COG0203; Pfam: PF01196; InterPro: IPR000456; Belongs to the bacterial ribosomal protein bL17 family. | 0.759 |
| hslR | rplS | HMPREF0758_1035 | HMPREF0758_0411 | S4 domain protein; COG: COG1188; Pfam: PF01479; InterPro: IPR002942; Belongs to the HSP15 family. | Ribosomal protein L19; This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site. | 0.809 |
| hslR | rplV | HMPREF0758_1035 | HMPREF0758_0956 | S4 domain protein; COG: COG1188; Pfam: PF01479; InterPro: IPR002942; Belongs to the HSP15 family. | Ribosomal protein L22; The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome. | 0.716 |
| hslR | rpmB | HMPREF0758_1035 | HMPREF0758_1264 | S4 domain protein; COG: COG1188; Pfam: PF01479; InterPro: IPR002942; Belongs to the HSP15 family. | Ribosomal protein L28; COG: COG0227; Pfam: PF00830; InterPro: IPR001383. | 0.797 |
| hslR | rpmH | HMPREF0758_1035 | HMPREF0758_1364 | S4 domain protein; COG: COG1188; Pfam: PF01479; InterPro: IPR002942; Belongs to the HSP15 family. | Ribosomal protein L34; Pfam: PF00468; InterPro: IPR000271. | 0.729 |
| hslR | yrfG | HMPREF0758_1035 | HMPREF0758_1034 | S4 domain protein; COG: COG1188; Pfam: PF01479; InterPro: IPR002942; Belongs to the HSP15 family. | HAD hydrolase, family IA, variant 3; COG: COG1011; Pfam: PF00702; InterPro: IPR005834. | 0.905 |
| macB | hslR | HMPREF0758_4460 | HMPREF0758_1035 | ABC transporter, ATP-binding protein; Part of the tripartite efflux system MacAB-TolC. MacB is a non-canonical ABC transporter that contains transmembrane domains (TMD), which form a pore in the inner membrane, and an ATP-binding domain (NBD), which is responsible for energy generation. Confers resistance against macrolides. | S4 domain protein; COG: COG1188; Pfam: PF01479; InterPro: IPR002942; Belongs to the HSP15 family. | 0.738 |
| macB | rplV | HMPREF0758_4460 | HMPREF0758_0956 | ABC transporter, ATP-binding protein; Part of the tripartite efflux system MacAB-TolC. MacB is a non-canonical ABC transporter that contains transmembrane domains (TMD), which form a pore in the inner membrane, and an ATP-binding domain (NBD), which is responsible for energy generation. Confers resistance against macrolides. | Ribosomal protein L22; The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome. | 0.476 |
| rplM | hslR | HMPREF0758_1872 | HMPREF0758_1035 | Ribosomal protein L13; This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly. | S4 domain protein; COG: COG1188; Pfam: PF01479; InterPro: IPR002942; Belongs to the HSP15 family. | 0.719 |
| rplM | rplN | HMPREF0758_1872 | HMPREF0758_0951 | Ribosomal protein L13; This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly. | Ribosomal protein L14; Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome; Belongs to the universal ribosomal protein uL14 family. | 0.998 |
| rplM | rplQ | HMPREF0758_1872 | HMPREF0758_0936 | Ribosomal protein L13; This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly. | Ribosomal protein L17; COG: COG0203; Pfam: PF01196; InterPro: IPR000456; Belongs to the bacterial ribosomal protein bL17 family. | 0.995 |
| rplM | rplS | HMPREF0758_1872 | HMPREF0758_0411 | Ribosomal protein L13; This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly. | Ribosomal protein L19; This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site. | 0.994 |
| rplM | rplV | HMPREF0758_1872 | HMPREF0758_0956 | Ribosomal protein L13; This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly. | Ribosomal protein L22; The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome. | 0.998 |
| rplM | rpmB | HMPREF0758_1872 | HMPREF0758_1264 | Ribosomal protein L13; This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly. | Ribosomal protein L28; COG: COG0227; Pfam: PF00830; InterPro: IPR001383. | 0.992 |