| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| cpxA | cpxP | HMPREF0758_1233 | HMPREF0758_1231 | Sensor protein CpxA; COG: COG0642; Pfam: PF00672,PF00512,PF02518; InterPro: IPR003594. | Periplasmic repressor CpxP; COG: COG3678; Pfam: PF07813. | 0.783 |
| cpxA | cpxR | HMPREF0758_1233 | HMPREF0758_1232 | Sensor protein CpxA; COG: COG0642; Pfam: PF00672,PF00512,PF02518; InterPro: IPR003594. | Transcriptional regulatory protein CpxR; COG: COG0745; Pfam: PF00072,PF00486; InterPro: IPR001789. | 0.999 |
| cpxA | yibK | HMPREF0758_1233 | HMPREF0758_1234 | Sensor protein CpxA; COG: COG0642; Pfam: PF00672,PF00512,PF02518; InterPro: IPR003594. | RNA methyltransferase, TrmH family, group 2; Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S-adenosyl-L-methionine to the 2'-OH of the wobble nucleotide. | 0.602 |
| cpxP | cpxA | HMPREF0758_1231 | HMPREF0758_1233 | Periplasmic repressor CpxP; COG: COG3678; Pfam: PF07813. | Sensor protein CpxA; COG: COG0642; Pfam: PF00672,PF00512,PF02518; InterPro: IPR003594. | 0.783 |
| cpxP | cpxR | HMPREF0758_1231 | HMPREF0758_1232 | Periplasmic repressor CpxP; COG: COG3678; Pfam: PF07813. | Transcriptional regulatory protein CpxR; COG: COG0745; Pfam: PF00072,PF00486; InterPro: IPR001789. | 0.618 |
| cpxP | yibK | HMPREF0758_1231 | HMPREF0758_1234 | Periplasmic repressor CpxP; COG: COG3678; Pfam: PF07813. | RNA methyltransferase, TrmH family, group 2; Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S-adenosyl-L-methionine to the 2'-OH of the wobble nucleotide. | 0.431 |
| cpxR | cpxA | HMPREF0758_1232 | HMPREF0758_1233 | Transcriptional regulatory protein CpxR; COG: COG0745; Pfam: PF00072,PF00486; InterPro: IPR001789. | Sensor protein CpxA; COG: COG0642; Pfam: PF00672,PF00512,PF02518; InterPro: IPR003594. | 0.999 |
| cpxR | cpxP | HMPREF0758_1232 | HMPREF0758_1231 | Transcriptional regulatory protein CpxR; COG: COG0745; Pfam: PF00072,PF00486; InterPro: IPR001789. | Periplasmic repressor CpxP; COG: COG3678; Pfam: PF07813. | 0.618 |
| cpxR | yibK | HMPREF0758_1232 | HMPREF0758_1234 | Transcriptional regulatory protein CpxR; COG: COG0745; Pfam: PF00072,PF00486; InterPro: IPR001789. | RNA methyltransferase, TrmH family, group 2; Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S-adenosyl-L-methionine to the 2'-OH of the wobble nucleotide. | 0.579 |
| hemF | yibK | HMPREF0758_2642 | HMPREF0758_1234 | Coproporphyrinogen III oxidase, aerobic; Involved in the heme biosynthesis. Catalyzes the aerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen-III to yield the vinyl groups in protoporphyrinogen- IX. | RNA methyltransferase, TrmH family, group 2; Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S-adenosyl-L-methionine to the 2'-OH of the wobble nucleotide. | 0.601 |
| mnmC | yibK | HMPREF0758_2732 | HMPREF0758_1234 | tRNA U-34 5-methylaminomethyl-2-thiouridine biosynthesis protein MnmC; Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34; In the C-terminal section; belongs to the DAO family. | RNA methyltransferase, TrmH family, group 2; Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S-adenosyl-L-methionine to the 2'-OH of the wobble nucleotide. | 0.514 |
| rlmH | rsmF | HMPREF0758_4915 | HMPREF0758_4017 | rRNA large subunit m3Psi methyltransferase RlmH; Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA; Belongs to the RNA methyltransferase RlmH family. | NOL1/NOP2/sun family protein; Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA. | 0.416 |
| rlmH | sun | HMPREF0758_4915 | HMPREF0758_0930 | rRNA large subunit m3Psi methyltransferase RlmH; Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA; Belongs to the RNA methyltransferase RlmH family. | Ribosomal RNA small subunit methyltransferase B; Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA. | 0.578 |
| rlmH | yibK | HMPREF0758_4915 | HMPREF0758_1234 | rRNA large subunit m3Psi methyltransferase RlmH; Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA; Belongs to the RNA methyltransferase RlmH family. | RNA methyltransferase, TrmH family, group 2; Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S-adenosyl-L-methionine to the 2'-OH of the wobble nucleotide. | 0.541 |
| rsmF | rlmH | HMPREF0758_4017 | HMPREF0758_4915 | NOL1/NOP2/sun family protein; Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA. | rRNA large subunit m3Psi methyltransferase RlmH; Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA; Belongs to the RNA methyltransferase RlmH family. | 0.416 |
| rsmF | sun | HMPREF0758_4017 | HMPREF0758_0930 | NOL1/NOP2/sun family protein; Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA. | Ribosomal RNA small subunit methyltransferase B; Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA. | 0.481 |
| rsmF | trmB | HMPREF0758_4017 | HMPREF0758_2107 | NOL1/NOP2/sun family protein; Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA. | tRNA (guanine-N(7)-)-methyltransferase; Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA; Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family. | 0.613 |
| rsmF | yibK | HMPREF0758_4017 | HMPREF0758_1234 | NOL1/NOP2/sun family protein; Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA. | RNA methyltransferase, TrmH family, group 2; Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S-adenosyl-L-methionine to the 2'-OH of the wobble nucleotide. | 0.438 |
| sun | rlmH | HMPREF0758_0930 | HMPREF0758_4915 | Ribosomal RNA small subunit methyltransferase B; Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA. | rRNA large subunit m3Psi methyltransferase RlmH; Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA; Belongs to the RNA methyltransferase RlmH family. | 0.578 |
| sun | rsmF | HMPREF0758_0930 | HMPREF0758_4017 | Ribosomal RNA small subunit methyltransferase B; Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA. | NOL1/NOP2/sun family protein; Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA. | 0.481 |