| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| RfaQ_1 | RfaQ_2 | HMPREF0758_1255 | HMPREF0758_1258 | Putative lipopolysaccharide heptosyltransferase III; COG: COG0859; Pfam: PF01075; InterPro: IPR011916. | Heptosyltransferase; Pfam: PF01075; InterPro: IPR002201. | 0.929 |
| RfaQ_1 | gmhB | HMPREF0758_1255 | HMPREF0758_2369 | Putative lipopolysaccharide heptosyltransferase III; COG: COG0859; Pfam: PF01075; InterPro: IPR011916. | D,D-heptose 1,7-bisphosphate phosphatase; COG: COG0241; Pfam: PF00702; InterPro: IPR004446. | 0.646 |
| RfaQ_1 | kdtA | HMPREF0758_1255 | HMPREF0758_1259 | Putative lipopolysaccharide heptosyltransferase III; COG: COG0859; Pfam: PF01075; InterPro: IPR011916. | 3-deoxy-D-manno-octulosonic-acid transferase; Involved in lipopolysaccharide (LPS) biosynthesis. Catalyzes the transfer of 3-deoxy-D-manno-octulosonate (Kdo) residue(s) from CMP- Kdo to lipid IV(A), the tetraacyldisaccharide-1,4'-bisphosphate precursor of lipid A; Belongs to the glycosyltransferase group 1 family. | 0.949 |
| RfaQ_1 | nuoD | HMPREF0758_1255 | HMPREF0758_2794 | Putative lipopolysaccharide heptosyltransferase III; COG: COG0859; Pfam: PF01075; InterPro: IPR011916. | NADH dehydrogenase subunit D; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient; In the C-terminal section; belongs to the complex I 49 kDa subunit family. | 0.897 |
| RfaQ_1 | rfaC | HMPREF0758_1255 | HMPREF0758_1248 | Putative lipopolysaccharide heptosyltransferase III; COG: COG0859; Pfam: PF01075; InterPro: IPR011916. | Lipopolysaccharide heptosyltransferase I; COG: COG0859; Pfam: PF01075; InterPro: IPR011908. | 0.966 |
| RfaQ_1 | rfaD | HMPREF0758_1255 | HMPREF0758_1246 | Putative lipopolysaccharide heptosyltransferase III; COG: COG0859; Pfam: PF01075; InterPro: IPR011916. | ADP-glyceromanno-heptose 6-epimerase; Catalyzes the interconversion between ADP-D-glycero-beta-D- manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose; Belongs to the NAD(P)-dependent epimerase/dehydratase family. HldD subfamily. | 0.583 |
| RfaQ_1 | rfaE | HMPREF0758_1255 | HMPREF0758_1943 | Putative lipopolysaccharide heptosyltransferase III; COG: COG0859; Pfam: PF01075; InterPro: IPR011916. | Bifunctional protein RfaE, domain I; Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno-heptose. In the N-terminal section; belongs to the carbohydrate kinase PfkB family. | 0.745 |
| RfaQ_1 | rfaF | HMPREF0758_1255 | HMPREF0758_1247 | Putative lipopolysaccharide heptosyltransferase III; COG: COG0859; Pfam: PF01075; InterPro: IPR011916. | Lipopolysaccharide heptosyltransferase II; COG: COG0859; Pfam: PF01075; InterPro: IPR011910. | 0.973 |
| RfaQ_1 | rfaG | HMPREF0758_1255 | HMPREF0758_1256 | Putative lipopolysaccharide heptosyltransferase III; COG: COG0859; Pfam: PF01075; InterPro: IPR011916. | Glycosyltransferase, group 1 family protein; Pfam: PF00534; InterPro: IPR001296. | 0.991 |
| RfaQ_1 | rfaL | HMPREF0758_1255 | HMPREF0758_1250 | Putative lipopolysaccharide heptosyltransferase III; COG: COG0859; Pfam: PF01075; InterPro: IPR011916. | O-antigen ligase; Pfam: PF04932. | 0.920 |
| RfaQ_2 | RfaQ_1 | HMPREF0758_1258 | HMPREF0758_1255 | Heptosyltransferase; Pfam: PF01075; InterPro: IPR002201. | Putative lipopolysaccharide heptosyltransferase III; COG: COG0859; Pfam: PF01075; InterPro: IPR011916. | 0.929 |
| RfaQ_2 | gmhB | HMPREF0758_1258 | HMPREF0758_2369 | Heptosyltransferase; Pfam: PF01075; InterPro: IPR002201. | D,D-heptose 1,7-bisphosphate phosphatase; COG: COG0241; Pfam: PF00702; InterPro: IPR004446. | 0.697 |
| RfaQ_2 | kdtA | HMPREF0758_1258 | HMPREF0758_1259 | Heptosyltransferase; Pfam: PF01075; InterPro: IPR002201. | 3-deoxy-D-manno-octulosonic-acid transferase; Involved in lipopolysaccharide (LPS) biosynthesis. Catalyzes the transfer of 3-deoxy-D-manno-octulosonate (Kdo) residue(s) from CMP- Kdo to lipid IV(A), the tetraacyldisaccharide-1,4'-bisphosphate precursor of lipid A; Belongs to the glycosyltransferase group 1 family. | 0.971 |
| RfaQ_2 | nuoD | HMPREF0758_1258 | HMPREF0758_2794 | Heptosyltransferase; Pfam: PF01075; InterPro: IPR002201. | NADH dehydrogenase subunit D; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient; In the C-terminal section; belongs to the complex I 49 kDa subunit family. | 0.897 |
| RfaQ_2 | rfaC | HMPREF0758_1258 | HMPREF0758_1248 | Heptosyltransferase; Pfam: PF01075; InterPro: IPR002201. | Lipopolysaccharide heptosyltransferase I; COG: COG0859; Pfam: PF01075; InterPro: IPR011908. | 0.951 |
| RfaQ_2 | rfaD | HMPREF0758_1258 | HMPREF0758_1246 | Heptosyltransferase; Pfam: PF01075; InterPro: IPR002201. | ADP-glyceromanno-heptose 6-epimerase; Catalyzes the interconversion between ADP-D-glycero-beta-D- manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose; Belongs to the NAD(P)-dependent epimerase/dehydratase family. HldD subfamily. | 0.411 |
| RfaQ_2 | rfaE | HMPREF0758_1258 | HMPREF0758_1943 | Heptosyltransferase; Pfam: PF01075; InterPro: IPR002201. | Bifunctional protein RfaE, domain I; Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno-heptose. In the N-terminal section; belongs to the carbohydrate kinase PfkB family. | 0.756 |
| RfaQ_2 | rfaF | HMPREF0758_1258 | HMPREF0758_1247 | Heptosyltransferase; Pfam: PF01075; InterPro: IPR002201. | Lipopolysaccharide heptosyltransferase II; COG: COG0859; Pfam: PF01075; InterPro: IPR011910. | 0.983 |
| RfaQ_2 | rfaG | HMPREF0758_1258 | HMPREF0758_1256 | Heptosyltransferase; Pfam: PF01075; InterPro: IPR002201. | Glycosyltransferase, group 1 family protein; Pfam: PF00534; InterPro: IPR001296. | 0.936 |
| RfaQ_2 | rfaL | HMPREF0758_1258 | HMPREF0758_1250 | Heptosyltransferase; Pfam: PF01075; InterPro: IPR002201. | O-antigen ligase; Pfam: PF04932. | 0.912 |