| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| EFE97175.1 | birA | HMPREF0758_1267 | HMPREF0758_1652 | Hypothetical protein; COG: COG0452; Pfam: PF04127; InterPro: IPR007085; 4.1.1.36; 6.3.2.5. | biotin--[acetyl-CoA-carboxylase] ligase; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio-5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon. | 0.459 |
| EFE97175.1 | coaBC | HMPREF0758_1267 | HMPREF0758_1266 | Hypothetical protein; COG: COG0452; Pfam: PF04127; InterPro: IPR007085; 4.1.1.36; 6.3.2.5. | Phosphopantothenoylcysteine decarboxylase/phosphopantothenate--cysteine ligase; COG: COG0452; Pfam: PF02441,PF04127; InterPro: IPR005252. | 0.991 |
| EFE97175.1 | dut | HMPREF0758_1267 | HMPREF0758_1268 | Hypothetical protein; COG: COG0452; Pfam: PF04127; InterPro: IPR007085; 4.1.1.36; 6.3.2.5. | dUTP diphosphatase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. | 0.903 |
| EFE97175.1 | pheT | HMPREF0758_1267 | HMPREF0758_3979 | Hypothetical protein; COG: COG0452; Pfam: PF04127; InterPro: IPR007085; 4.1.1.36; 6.3.2.5. | phenylalanine--tRNA ligase, beta subunit; COG: COG0072; Pfam: PF01588,PF03483,PF03484,PF03147; InterPro: IPR004532; Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily. | 0.421 |
| EFE97175.1 | priA | HMPREF0758_1267 | HMPREF0758_1164 | Hypothetical protein; COG: COG0452; Pfam: PF04127; InterPro: IPR007085; 4.1.1.36; 6.3.2.5. | Primosomal protein N; Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA; Belongs to the helicase family. PriA subfamily. | 0.619 |
| EFE97175.1 | radC-2 | HMPREF0758_1267 | HMPREF0758_1265 | Hypothetical protein; COG: COG0452; Pfam: PF04127; InterPro: IPR007085; 4.1.1.36; 6.3.2.5. | DNA repair protein RadC; COG: COG2003; Pfam: PF04002; InterPro: IPR001405; Belongs to the UPF0758 family. YicR subfamily. | 0.592 |
| EFE97175.1 | ribD | HMPREF0758_1267 | HMPREF0758_0227 | Hypothetical protein; COG: COG0452; Pfam: PF04127; InterPro: IPR007085; 4.1.1.36; 6.3.2.5. | Riboflavin biosynthesis protein RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | 0.515 |
| EFE97175.1 | ribF | HMPREF0758_1267 | HMPREF0758_0575 | Hypothetical protein; COG: COG0452; Pfam: PF04127; InterPro: IPR007085; 4.1.1.36; 6.3.2.5. | Riboflavin biosynthesis protein RibF; COG: COG0196; Pfam: PF06574,PF01687; InterPro: IPR002606; Belongs to the ribF family. | 0.432 |
| EFE97175.1 | slmA | HMPREF0758_1267 | HMPREF0758_1269 | Hypothetical protein; COG: COG0452; Pfam: PF04127; InterPro: IPR007085; 4.1.1.36; 6.3.2.5. | Transcriptional regulator, TetR family; Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid. Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers. SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions. | 0.494 |
| EFE97175.1 | sun | HMPREF0758_1267 | HMPREF0758_0930 | Hypothetical protein; COG: COG0452; Pfam: PF04127; InterPro: IPR007085; 4.1.1.36; 6.3.2.5. | Ribosomal RNA small subunit methyltransferase B; Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA. | 0.413 |
| birA | EFE97175.1 | HMPREF0758_1652 | HMPREF0758_1267 | biotin--[acetyl-CoA-carboxylase] ligase; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio-5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon. | Hypothetical protein; COG: COG0452; Pfam: PF04127; InterPro: IPR007085; 4.1.1.36; 6.3.2.5. | 0.459 |
| birA | coaBC | HMPREF0758_1652 | HMPREF0758_1266 | biotin--[acetyl-CoA-carboxylase] ligase; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio-5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon. | Phosphopantothenoylcysteine decarboxylase/phosphopantothenate--cysteine ligase; COG: COG0452; Pfam: PF02441,PF04127; InterPro: IPR005252. | 0.459 |
| birA | pheT | HMPREF0758_1652 | HMPREF0758_3979 | biotin--[acetyl-CoA-carboxylase] ligase; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio-5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon. | phenylalanine--tRNA ligase, beta subunit; COG: COG0072; Pfam: PF01588,PF03483,PF03484,PF03147; InterPro: IPR004532; Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily. | 0.554 |
| birA | ribD | HMPREF0758_1652 | HMPREF0758_0227 | biotin--[acetyl-CoA-carboxylase] ligase; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio-5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon. | Riboflavin biosynthesis protein RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | 0.611 |
| birA | ribF | HMPREF0758_1652 | HMPREF0758_0575 | biotin--[acetyl-CoA-carboxylase] ligase; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio-5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon. | Riboflavin biosynthesis protein RibF; COG: COG0196; Pfam: PF06574,PF01687; InterPro: IPR002606; Belongs to the ribF family. | 0.505 |
| coaBC | EFE97175.1 | HMPREF0758_1266 | HMPREF0758_1267 | Phosphopantothenoylcysteine decarboxylase/phosphopantothenate--cysteine ligase; COG: COG0452; Pfam: PF02441,PF04127; InterPro: IPR005252. | Hypothetical protein; COG: COG0452; Pfam: PF04127; InterPro: IPR007085; 4.1.1.36; 6.3.2.5. | 0.991 |
| coaBC | birA | HMPREF0758_1266 | HMPREF0758_1652 | Phosphopantothenoylcysteine decarboxylase/phosphopantothenate--cysteine ligase; COG: COG0452; Pfam: PF02441,PF04127; InterPro: IPR005252. | biotin--[acetyl-CoA-carboxylase] ligase; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio-5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon. | 0.459 |
| coaBC | dut | HMPREF0758_1266 | HMPREF0758_1268 | Phosphopantothenoylcysteine decarboxylase/phosphopantothenate--cysteine ligase; COG: COG0452; Pfam: PF02441,PF04127; InterPro: IPR005252. | dUTP diphosphatase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. | 0.938 |
| coaBC | priA | HMPREF0758_1266 | HMPREF0758_1164 | Phosphopantothenoylcysteine decarboxylase/phosphopantothenate--cysteine ligase; COG: COG0452; Pfam: PF02441,PF04127; InterPro: IPR005252. | Primosomal protein N; Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA; Belongs to the helicase family. PriA subfamily. | 0.548 |
| coaBC | radC-2 | HMPREF0758_1266 | HMPREF0758_1265 | Phosphopantothenoylcysteine decarboxylase/phosphopantothenate--cysteine ligase; COG: COG0452; Pfam: PF02441,PF04127; InterPro: IPR005252. | DNA repair protein RadC; COG: COG2003; Pfam: PF04002; InterPro: IPR001405; Belongs to the UPF0758 family. YicR subfamily. | 0.633 |