| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| AlkA | ogt2 | HMPREF0758_2577 | HMPREF0758_3647 | AlkA N-terminal domain protein; COG: COG0122; Pfam: PF02805,PF00165,PF06029,PF00730; InterPro: IPR003265. | 6-O-methylguanine DNA methyltransferase, DNA binding domain protein; Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated. | 0.912 |
| AlkA | polA | HMPREF0758_2577 | HMPREF0758_1303 | AlkA N-terminal domain protein; COG: COG0122; Pfam: PF02805,PF00165,PF06029,PF00730; InterPro: IPR003265. | DNA-directed DNA polymerase; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. | 0.632 |
| AlkA | tag | HMPREF0758_2577 | HMPREF0758_1396 | AlkA N-terminal domain protein; COG: COG0122; Pfam: PF02805,PF00165,PF06029,PF00730; InterPro: IPR003265. | DNA-3-methyladenine glycosylase I; COG: COG2818; Pfam: PF03352; InterPro: IPR004597. | 0.606 |
| apeE | tag | HMPREF0758_1397 | HMPREF0758_1396 | Outer membrane autotransporter barrel domain protein; Pfam: PF00657,PF03797; InterPro: IPR001087. | DNA-3-methyladenine glycosylase I; COG: COG2818; Pfam: PF03352; InterPro: IPR004597. | 0.652 |
| ogt2 | AlkA | HMPREF0758_3647 | HMPREF0758_2577 | 6-O-methylguanine DNA methyltransferase, DNA binding domain protein; Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated. | AlkA N-terminal domain protein; COG: COG0122; Pfam: PF02805,PF00165,PF06029,PF00730; InterPro: IPR003265. | 0.912 |
| ogt2 | polA | HMPREF0758_3647 | HMPREF0758_1303 | 6-O-methylguanine DNA methyltransferase, DNA binding domain protein; Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated. | DNA-directed DNA polymerase; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. | 0.583 |
| ogt2 | tag | HMPREF0758_3647 | HMPREF0758_1396 | 6-O-methylguanine DNA methyltransferase, DNA binding domain protein; Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated. | DNA-3-methyladenine glycosylase I; COG: COG2818; Pfam: PF03352; InterPro: IPR004597. | 0.766 |
| polA | AlkA | HMPREF0758_1303 | HMPREF0758_2577 | DNA-directed DNA polymerase; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. | AlkA N-terminal domain protein; COG: COG0122; Pfam: PF02805,PF00165,PF06029,PF00730; InterPro: IPR003265. | 0.632 |
| polA | ogt2 | HMPREF0758_1303 | HMPREF0758_3647 | DNA-directed DNA polymerase; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. | 6-O-methylguanine DNA methyltransferase, DNA binding domain protein; Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated. | 0.583 |
| polA | tag | HMPREF0758_1303 | HMPREF0758_1396 | DNA-directed DNA polymerase; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. | DNA-3-methyladenine glycosylase I; COG: COG2818; Pfam: PF03352; InterPro: IPR004597. | 0.597 |
| tag | AlkA | HMPREF0758_1396 | HMPREF0758_2577 | DNA-3-methyladenine glycosylase I; COG: COG2818; Pfam: PF03352; InterPro: IPR004597. | AlkA N-terminal domain protein; COG: COG0122; Pfam: PF02805,PF00165,PF06029,PF00730; InterPro: IPR003265. | 0.606 |
| tag | apeE | HMPREF0758_1396 | HMPREF0758_1397 | DNA-3-methyladenine glycosylase I; COG: COG2818; Pfam: PF03352; InterPro: IPR004597. | Outer membrane autotransporter barrel domain protein; Pfam: PF00657,PF03797; InterPro: IPR001087. | 0.652 |
| tag | ogt2 | HMPREF0758_1396 | HMPREF0758_3647 | DNA-3-methyladenine glycosylase I; COG: COG2818; Pfam: PF03352; InterPro: IPR004597. | 6-O-methylguanine DNA methyltransferase, DNA binding domain protein; Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated. | 0.766 |
| tag | polA | HMPREF0758_1396 | HMPREF0758_1303 | DNA-3-methyladenine glycosylase I; COG: COG2818; Pfam: PF03352; InterPro: IPR004597. | DNA-directed DNA polymerase; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. | 0.597 |