| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| YigZ | fadB | HMPREF0758_1648 | HMPREF0758_1645 | YigZ family protein; COG: COG1739; Pfam: PF01205,PF09186; InterPro: IPR015796. | Fatty oxidation complex, alpha subunit FadB; Involved in the aerobic and anaerobic degradation of long- chain fatty acids via beta-oxidation cycle. Catalyzes the formation of 3-oxoacyl-CoA from enoyl-CoA via L-3-hydroxyacyl-CoA. It can also use D-3-hydroxyacyl-CoA and cis-3-enoyl-CoA as substrate. In the N-terminal section; belongs to the enoyl-CoA hydratase/isomerase family. | 0.453 |
| YigZ | hemG | HMPREF0758_1648 | HMPREF0758_1650 | YigZ family protein; COG: COG1739; Pfam: PF01205,PF09186; InterPro: IPR015796. | Putative protoporphyrinogen oxidase; COG: COG4635. | 0.642 |
| YigZ | pepQ | HMPREF0758_1648 | HMPREF0758_1647 | YigZ family protein; COG: COG1739; Pfam: PF01205,PF09186; InterPro: IPR015796. | Peptidase, M24 family; Splits dipeptides with a prolyl residue in the C-terminal position. | 0.643 |
| YigZ | trkH | HMPREF0758_1648 | HMPREF0758_1649 | YigZ family protein; COG: COG1739; Pfam: PF01205,PF09186; InterPro: IPR015796. | Potassium uptake protein, TrkH family; Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA; Belongs to the TrkH potassium transport family. | 0.676 |
| cyaA | hemG | HMPREF0758_1532 | HMPREF0758_1650 | Adenylate cyclase, class I; COG: COG3072; Pfam: PF01295; InterPro: IPR000274; Belongs to the adenylyl cyclase class-1 family. | Putative protoporphyrinogen oxidase; COG: COG4635. | 0.424 |
| fadB | YigZ | HMPREF0758_1645 | HMPREF0758_1648 | Fatty oxidation complex, alpha subunit FadB; Involved in the aerobic and anaerobic degradation of long- chain fatty acids via beta-oxidation cycle. Catalyzes the formation of 3-oxoacyl-CoA from enoyl-CoA via L-3-hydroxyacyl-CoA. It can also use D-3-hydroxyacyl-CoA and cis-3-enoyl-CoA as substrate. In the N-terminal section; belongs to the enoyl-CoA hydratase/isomerase family. | YigZ family protein; COG: COG1739; Pfam: PF01205,PF09186; InterPro: IPR015796. | 0.453 |
| fadB | hemG | HMPREF0758_1645 | HMPREF0758_1650 | Fatty oxidation complex, alpha subunit FadB; Involved in the aerobic and anaerobic degradation of long- chain fatty acids via beta-oxidation cycle. Catalyzes the formation of 3-oxoacyl-CoA from enoyl-CoA via L-3-hydroxyacyl-CoA. It can also use D-3-hydroxyacyl-CoA and cis-3-enoyl-CoA as substrate. In the N-terminal section; belongs to the enoyl-CoA hydratase/isomerase family. | Putative protoporphyrinogen oxidase; COG: COG4635. | 0.408 |
| fadB | pepQ | HMPREF0758_1645 | HMPREF0758_1647 | Fatty oxidation complex, alpha subunit FadB; Involved in the aerobic and anaerobic degradation of long- chain fatty acids via beta-oxidation cycle. Catalyzes the formation of 3-oxoacyl-CoA from enoyl-CoA via L-3-hydroxyacyl-CoA. It can also use D-3-hydroxyacyl-CoA and cis-3-enoyl-CoA as substrate. In the N-terminal section; belongs to the enoyl-CoA hydratase/isomerase family. | Peptidase, M24 family; Splits dipeptides with a prolyl residue in the C-terminal position. | 0.499 |
| hemF | hemG | HMPREF0758_2642 | HMPREF0758_1650 | Coproporphyrinogen III oxidase, aerobic; Involved in the heme biosynthesis. Catalyzes the aerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen-III to yield the vinyl groups in protoporphyrinogen- IX. | Putative protoporphyrinogen oxidase; COG: COG4635. | 0.927 |
| hemF | hemH | HMPREF0758_2642 | HMPREF0758_0150 | Coproporphyrinogen III oxidase, aerobic; Involved in the heme biosynthesis. Catalyzes the aerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen-III to yield the vinyl groups in protoporphyrinogen- IX. | Ferrochelatase; Catalyzes the ferrous insertion into protoporphyrin IX. Belongs to the ferrochelatase family. | 0.667 |
| hemF | hemN | HMPREF0758_2642 | HMPREF0758_1300 | Coproporphyrinogen III oxidase, aerobic; Involved in the heme biosynthesis. Catalyzes the aerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen-III to yield the vinyl groups in protoporphyrinogen- IX. | Coproporphyrinogen dehydrogenase; COG: COG0635; Pfam: PF04055,PF06969; InterPro: IPR004558; Belongs to the anaerobic coproporphyrinogen-III oxidase family. | 0.940 |
| hemG | YigZ | HMPREF0758_1650 | HMPREF0758_1648 | Putative protoporphyrinogen oxidase; COG: COG4635. | YigZ family protein; COG: COG1739; Pfam: PF01205,PF09186; InterPro: IPR015796. | 0.642 |
| hemG | cyaA | HMPREF0758_1650 | HMPREF0758_1532 | Putative protoporphyrinogen oxidase; COG: COG4635. | Adenylate cyclase, class I; COG: COG3072; Pfam: PF01295; InterPro: IPR000274; Belongs to the adenylyl cyclase class-1 family. | 0.424 |
| hemG | fadB | HMPREF0758_1650 | HMPREF0758_1645 | Putative protoporphyrinogen oxidase; COG: COG4635. | Fatty oxidation complex, alpha subunit FadB; Involved in the aerobic and anaerobic degradation of long- chain fatty acids via beta-oxidation cycle. Catalyzes the formation of 3-oxoacyl-CoA from enoyl-CoA via L-3-hydroxyacyl-CoA. It can also use D-3-hydroxyacyl-CoA and cis-3-enoyl-CoA as substrate. In the N-terminal section; belongs to the enoyl-CoA hydratase/isomerase family. | 0.408 |
| hemG | hemF | HMPREF0758_1650 | HMPREF0758_2642 | Putative protoporphyrinogen oxidase; COG: COG4635. | Coproporphyrinogen III oxidase, aerobic; Involved in the heme biosynthesis. Catalyzes the aerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen-III to yield the vinyl groups in protoporphyrinogen- IX. | 0.927 |
| hemG | hemH | HMPREF0758_1650 | HMPREF0758_0150 | Putative protoporphyrinogen oxidase; COG: COG4635. | Ferrochelatase; Catalyzes the ferrous insertion into protoporphyrin IX. Belongs to the ferrochelatase family. | 0.928 |
| hemG | hemN | HMPREF0758_1650 | HMPREF0758_1300 | Putative protoporphyrinogen oxidase; COG: COG4635. | Coproporphyrinogen dehydrogenase; COG: COG0635; Pfam: PF04055,PF06969; InterPro: IPR004558; Belongs to the anaerobic coproporphyrinogen-III oxidase family. | 0.922 |
| hemG | pepQ | HMPREF0758_1650 | HMPREF0758_1647 | Putative protoporphyrinogen oxidase; COG: COG4635. | Peptidase, M24 family; Splits dipeptides with a prolyl residue in the C-terminal position. | 0.453 |
| hemG | trkH | HMPREF0758_1650 | HMPREF0758_1649 | Putative protoporphyrinogen oxidase; COG: COG4635. | Potassium uptake protein, TrkH family; Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA; Belongs to the TrkH potassium transport family. | 0.768 |
| hemH | hemF | HMPREF0758_0150 | HMPREF0758_2642 | Ferrochelatase; Catalyzes the ferrous insertion into protoporphyrin IX. Belongs to the ferrochelatase family. | Coproporphyrinogen III oxidase, aerobic; Involved in the heme biosynthesis. Catalyzes the aerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen-III to yield the vinyl groups in protoporphyrinogen- IX. | 0.667 |