| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| NadR_1 | cobB | HMPREF0758_0608 | HMPREF0758_4163 | Nicotinamide-nucleotide adenylyltransferase; COG: COG3172; Pfam: PF01381; InterPro: IPR006417. | Transcriptional regulator, Sir2 family; COG: COG0846; Pfam: PF02146; InterPro: IPR003000; Belongs to the sirtuin family. Class III subfamily. | 0.996 |
| NadR_1 | mazG | HMPREF0758_0608 | HMPREF0758_0474 | Nicotinamide-nucleotide adenylyltransferase; COG: COG3172; Pfam: PF01381; InterPro: IPR006417. | Protein MazG; COG: COG1694; Pfam: PF03819; InterPro: IPR011551. | 0.906 |
| NadR_1 | nadC | HMPREF0758_0608 | HMPREF0758_0495 | Nicotinamide-nucleotide adenylyltransferase; COG: COG3172; Pfam: PF01381; InterPro: IPR006417. | Quinolinate phosphoribosyl transferase, C-terminal domain protein; COG: COG0157; Pfam: PF01729; InterPro: IPR013785. | 0.942 |
| NadR_1 | nadD | HMPREF0758_0608 | HMPREF0758_4913 | Nicotinamide-nucleotide adenylyltransferase; COG: COG3172; Pfam: PF01381; InterPro: IPR006417. | Nicotinate-nucleotide adenylyltransferase; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD). | 0.941 |
| NadR_1 | nadE | HMPREF0758_0608 | HMPREF0758_2475 | Nicotinamide-nucleotide adenylyltransferase; COG: COG3172; Pfam: PF01381; InterPro: IPR006417. | NAD+ synthase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source. | 0.956 |
| NadR_1 | nudC | HMPREF0758_0608 | HMPREF0758_1672 | Nicotinamide-nucleotide adenylyltransferase; COG: COG3172; Pfam: PF01381; InterPro: IPR006417. | NAD(+) diphosphatase; COG: COG2816; Pfam: PF09296,PF09297,PF00293; InterPro: IPR000086; Belongs to the Nudix hydrolase family. NudC subfamily. | 0.905 |
| NadR_1 | pncB | HMPREF0758_0608 | HMPREF0758_4360 | Nicotinamide-nucleotide adenylyltransferase; COG: COG3172; Pfam: PF01381; InterPro: IPR006417. | Nicotinate phosphoribosyltransferase; Catalyzes the synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP; Belongs to the NAPRTase family. | 0.953 |
| NadR_1 | sthA | HMPREF0758_0608 | HMPREF0758_1148 | Nicotinamide-nucleotide adenylyltransferase; COG: COG3172; Pfam: PF01381; InterPro: IPR006417. | Pyridine nucleotide-disulfide oxidoreductase, dimerization domain protein; COG: COG1249; Pfam: PF00070,PF02852; InterPro: IPR004099. | 0.900 |
| NadR_1 | surE | HMPREF0758_0608 | HMPREF0758_0436 | Nicotinamide-nucleotide adenylyltransferase; COG: COG3172; Pfam: PF01381; InterPro: IPR006417. | 5'/3'-nucleotidase SurE; Nucleotidase with a broad substrate specificity as it can dephosphorylate various ribo- and deoxyribonucleoside 5'-monophosphates and ribonucleoside 3'-monophosphates with highest affinity to 3'-AMP. Also hydrolyzes polyphosphate (exopolyphosphatase activity) with the preference for short-chain-length substrates (P20-25). Might be involved in the regulation of dNTP and NTP pools, and in the turnover of 3'-mononucleotides produced by numerous intracellular RNases (T1, T2, and F) during the degradation of various RNAs. | 0.900 |
| NadR_1 | ushA | HMPREF0758_0608 | HMPREF0758_0145 | Nicotinamide-nucleotide adenylyltransferase; COG: COG3172; Pfam: PF01381; InterPro: IPR006417. | 5'-nucleotidase, C-terminal domain protein; COG: COG0737; Pfam: PF00149,PF02872; InterPro: IPR006179; Belongs to the 5'-nucleotidase family. | 0.911 |
| cobB | NadR_1 | HMPREF0758_4163 | HMPREF0758_0608 | Transcriptional regulator, Sir2 family; COG: COG0846; Pfam: PF02146; InterPro: IPR003000; Belongs to the sirtuin family. Class III subfamily. | Nicotinamide-nucleotide adenylyltransferase; COG: COG3172; Pfam: PF01381; InterPro: IPR006417. | 0.996 |
| cobB | mazG | HMPREF0758_4163 | HMPREF0758_0474 | Transcriptional regulator, Sir2 family; COG: COG0846; Pfam: PF02146; InterPro: IPR003000; Belongs to the sirtuin family. Class III subfamily. | Protein MazG; COG: COG1694; Pfam: PF03819; InterPro: IPR011551. | 0.901 |
| cobB | nadD | HMPREF0758_4163 | HMPREF0758_4913 | Transcriptional regulator, Sir2 family; COG: COG0846; Pfam: PF02146; InterPro: IPR003000; Belongs to the sirtuin family. Class III subfamily. | Nicotinate-nucleotide adenylyltransferase; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD). | 0.939 |
| cobB | nadE | HMPREF0758_4163 | HMPREF0758_2475 | Transcriptional regulator, Sir2 family; COG: COG0846; Pfam: PF02146; InterPro: IPR003000; Belongs to the sirtuin family. Class III subfamily. | NAD+ synthase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source. | 0.949 |
| cobB | nudC | HMPREF0758_4163 | HMPREF0758_1672 | Transcriptional regulator, Sir2 family; COG: COG0846; Pfam: PF02146; InterPro: IPR003000; Belongs to the sirtuin family. Class III subfamily. | NAD(+) diphosphatase; COG: COG2816; Pfam: PF09296,PF09297,PF00293; InterPro: IPR000086; Belongs to the Nudix hydrolase family. NudC subfamily. | 0.905 |
| cobB | sthA | HMPREF0758_4163 | HMPREF0758_1148 | Transcriptional regulator, Sir2 family; COG: COG0846; Pfam: PF02146; InterPro: IPR003000; Belongs to the sirtuin family. Class III subfamily. | Pyridine nucleotide-disulfide oxidoreductase, dimerization domain protein; COG: COG1249; Pfam: PF00070,PF02852; InterPro: IPR004099. | 0.915 |
| mazG | NadR_1 | HMPREF0758_0474 | HMPREF0758_0608 | Protein MazG; COG: COG1694; Pfam: PF03819; InterPro: IPR011551. | Nicotinamide-nucleotide adenylyltransferase; COG: COG3172; Pfam: PF01381; InterPro: IPR006417. | 0.906 |
| mazG | cobB | HMPREF0758_0474 | HMPREF0758_4163 | Protein MazG; COG: COG1694; Pfam: PF03819; InterPro: IPR011551. | Transcriptional regulator, Sir2 family; COG: COG0846; Pfam: PF02146; InterPro: IPR003000; Belongs to the sirtuin family. Class III subfamily. | 0.901 |
| mazG | nadC | HMPREF0758_0474 | HMPREF0758_0495 | Protein MazG; COG: COG1694; Pfam: PF03819; InterPro: IPR011551. | Quinolinate phosphoribosyl transferase, C-terminal domain protein; COG: COG0157; Pfam: PF01729; InterPro: IPR013785. | 0.904 |
| mazG | nadD | HMPREF0758_0474 | HMPREF0758_4913 | Protein MazG; COG: COG1694; Pfam: PF03819; InterPro: IPR011551. | Nicotinate-nucleotide adenylyltransferase; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD). | 0.904 |