STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
aceAIsocitrate lyase; COG: COG2224; Pfam: PF00463; InterPro: IPR015813. (435 aa)    
Predicted Functional Partners:
aceB
Malate synthase A; COG: COG2225; Pfam: PF01274; InterPro: IPR001465; Belongs to the malate synthase family.
 
 0.999
aceK
[isocitrate dehydrogenase (NADP(+))] kinase; Bifunctional enzyme which can phosphorylate or dephosphorylate isocitrate dehydrogenase (IDH) on a specific serine residue. This is a regulatory mechanism which enables bacteria to bypass the Krebs cycle via the glyoxylate shunt in response to the source of carbon. When bacteria are grown on glucose, IDH is fully active and unphosphorylated, but when grown on acetate or ethanol, the activity of IDH declines drastically concomitant with its phosphorylation.
 
  
 0.940
acnA
Aconitate hydratase 1; Catalyzes the isomerization of citrate to isocitrate via cis- aconitate.
   
 
 0.938
acnB
Aconitate hydratase 2; COG: COG1049; Pfam: PF06434,PF00330; InterPro: IPR004406; Belongs to the aconitase/IPM isomerase family.
     
 0.916
pdxB
4-phosphoerythronate dehydrogenase; Catalyzes the NADPH-dependent reduction of glyoxylate and hydroxypyruvate into glycolate and glycerate, respectively. Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. GhrB subfamily.
     
 0.911
pdxB-3
4-phosphoerythronate dehydrogenase; Catalyzes the NADPH-dependent reduction of glyoxylate and hydroxypyruvate into glycolate and glycerate, respectively.
   
 
 0.910
pdxB-5
4-phosphoerythronate dehydrogenase; COG: COG0111; Pfam: PF02826; InterPro: IPR016040.
   
 
 0.910
eda-2
2-dehydro-3-deoxyphosphogluconate aldolase/4-hydroxy-2-oxoglutarate aldolase; COG: COG0800; Pfam: PF01081; InterPro: IPR013785.
     
 0.904
eda-3
KHG/KDPG aldolase; COG: COG0800; Pfam: PF01081; InterPro: IPR013785.
     
 0.904
ackA
Acetate kinase; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family.
   
  
 0.792
Your Current Organism:
Serratia odorifera
NCBI taxonomy Id: 667129
Other names: S. odorifera DSM 4582, Serratia odorifera DSM 4582, Serratia odorifera str. DSM 4582, Serratia odorifera strain DSM 4582
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