STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
aceK[isocitrate dehydrogenase (NADP(+))] kinase; Bifunctional enzyme which can phosphorylate or dephosphorylate isocitrate dehydrogenase (IDH) on a specific serine residue. This is a regulatory mechanism which enables bacteria to bypass the Krebs cycle via the glyoxylate shunt in response to the source of carbon. When bacteria are grown on glucose, IDH is fully active and unphosphorylated, but when grown on acetate or ethanol, the activity of IDH declines drastically concomitant with its phosphorylation. (584 aa)    
Predicted Functional Partners:
aceA
Isocitrate lyase; COG: COG2224; Pfam: PF00463; InterPro: IPR015813.
 
  
 0.940
Icd_1
Hypothetical protein; COG: COG0538; Pfam: PF00180; InterPro: IPR001804; 1.1.1.42.
 
 
 
 0.811
icd
Isocitrate dehydrogenase, NADP-dependent; COG: COG0538; Pfam: PF00180; InterPro: IPR004439.
 
 
 
 0.805
aceB
Malate synthase A; COG: COG2225; Pfam: PF01274; InterPro: IPR001465; Belongs to the malate synthase family.
 
  
 0.771
putA
Delta-1-pyrroline-5-carboxylate dehydrogenase; Oxidizes proline to glutamate for use as a carbon and nitrogen source; Belongs to the aldehyde dehydrogenase family. In the N-terminal section; belongs to the proline dehydrogenase family.
      
 0.408
Your Current Organism:
Serratia odorifera
NCBI taxonomy Id: 667129
Other names: S. odorifera DSM 4582, Serratia odorifera DSM 4582, Serratia odorifera str. DSM 4582, Serratia odorifera strain DSM 4582
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.