| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| apt | purC | HMPREF0758_0160 | HMPREF0758_2603 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | Phosphoribosylaminoimidazolesuccinocarboxamide synthase; COG: COG0152; Pfam: PF01259; InterPro: IPR001636; Belongs to the SAICAR synthetase family. | 0.412 |
| apt | purH | HMPREF0758_0160 | HMPREF0758_1679 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | Phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; COG: COG0138; Pfam: PF02142,PF01808; InterPro: IPR002695. | 0.957 |
| apt | purL | HMPREF0758_0160 | HMPREF0758_2470 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | Phosphoribosylformylglycinamidine synthase; Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. | 0.771 |
| apt | yieG | HMPREF0758_0160 | HMPREF0758_1350 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | Putative permease; COG: COG2252; Pfam: PF00860; InterPro: IPR006043. | 0.431 |
| apt | yjcD | HMPREF0758_0160 | HMPREF0758_1796 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | Putative permease; COG: COG2252; Pfam: PF00860; InterPro: IPR006043. | 0.414 |
| pbuX | purL | HMPREF0758_0343 | HMPREF0758_2470 | Xanthine permease; COG: COG2233; Pfam: PF00860; InterPro: IPR006042. | Phosphoribosylformylglycinamidine synthase; Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. | 0.721 |
| pbuX | yieG | HMPREF0758_0343 | HMPREF0758_1350 | Xanthine permease; COG: COG2233; Pfam: PF00860; InterPro: IPR006042. | Putative permease; COG: COG2252; Pfam: PF00860; InterPro: IPR006043. | 0.584 |
| pbuX | yjcD | HMPREF0758_0343 | HMPREF0758_1796 | Xanthine permease; COG: COG2233; Pfam: PF00860; InterPro: IPR006042. | Putative permease; COG: COG2252; Pfam: PF00860; InterPro: IPR006043. | 0.599 |
| purC | apt | HMPREF0758_2603 | HMPREF0758_0160 | Phosphoribosylaminoimidazolesuccinocarboxamide synthase; COG: COG0152; Pfam: PF01259; InterPro: IPR001636; Belongs to the SAICAR synthetase family. | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | 0.412 |
| purC | purD | HMPREF0758_2603 | HMPREF0758_1678 | Phosphoribosylaminoimidazolesuccinocarboxamide synthase; COG: COG0152; Pfam: PF01259; InterPro: IPR001636; Belongs to the SAICAR synthetase family. | Phosphoribosylamine--glycine ligase; COG: COG0151; Pfam: PF02844,PF01071,PF02843; InterPro: IPR000115; Belongs to the GARS family. | 0.985 |
| purC | purH | HMPREF0758_2603 | HMPREF0758_1679 | Phosphoribosylaminoimidazolesuccinocarboxamide synthase; COG: COG0152; Pfam: PF01259; InterPro: IPR001636; Belongs to the SAICAR synthetase family. | Phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; COG: COG0138; Pfam: PF02142,PF01808; InterPro: IPR002695. | 0.983 |
| purC | purL | HMPREF0758_2603 | HMPREF0758_2470 | Phosphoribosylaminoimidazolesuccinocarboxamide synthase; COG: COG0152; Pfam: PF01259; InterPro: IPR001636; Belongs to the SAICAR synthetase family. | Phosphoribosylformylglycinamidine synthase; Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. | 0.999 |
| purC | yieG | HMPREF0758_2603 | HMPREF0758_1350 | Phosphoribosylaminoimidazolesuccinocarboxamide synthase; COG: COG0152; Pfam: PF01259; InterPro: IPR001636; Belongs to the SAICAR synthetase family. | Putative permease; COG: COG2252; Pfam: PF00860; InterPro: IPR006043. | 0.406 |
| purC | yjcD | HMPREF0758_2603 | HMPREF0758_1796 | Phosphoribosylaminoimidazolesuccinocarboxamide synthase; COG: COG0152; Pfam: PF01259; InterPro: IPR001636; Belongs to the SAICAR synthetase family. | Putative permease; COG: COG2252; Pfam: PF00860; InterPro: IPR006043. | 0.406 |
| purD | purC | HMPREF0758_1678 | HMPREF0758_2603 | Phosphoribosylamine--glycine ligase; COG: COG0151; Pfam: PF02844,PF01071,PF02843; InterPro: IPR000115; Belongs to the GARS family. | Phosphoribosylaminoimidazolesuccinocarboxamide synthase; COG: COG0152; Pfam: PF01259; InterPro: IPR001636; Belongs to the SAICAR synthetase family. | 0.985 |
| purD | purH | HMPREF0758_1678 | HMPREF0758_1679 | Phosphoribosylamine--glycine ligase; COG: COG0151; Pfam: PF02844,PF01071,PF02843; InterPro: IPR000115; Belongs to the GARS family. | Phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; COG: COG0138; Pfam: PF02142,PF01808; InterPro: IPR002695. | 0.995 |
| purD | purL | HMPREF0758_1678 | HMPREF0758_2470 | Phosphoribosylamine--glycine ligase; COG: COG0151; Pfam: PF02844,PF01071,PF02843; InterPro: IPR000115; Belongs to the GARS family. | Phosphoribosylformylglycinamidine synthase; Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. | 0.999 |
| purD | yieG | HMPREF0758_1678 | HMPREF0758_1350 | Phosphoribosylamine--glycine ligase; COG: COG0151; Pfam: PF02844,PF01071,PF02843; InterPro: IPR000115; Belongs to the GARS family. | Putative permease; COG: COG2252; Pfam: PF00860; InterPro: IPR006043. | 0.411 |
| purD | yjcD | HMPREF0758_1678 | HMPREF0758_1796 | Phosphoribosylamine--glycine ligase; COG: COG0151; Pfam: PF02844,PF01071,PF02843; InterPro: IPR000115; Belongs to the GARS family. | Putative permease; COG: COG2252; Pfam: PF00860; InterPro: IPR006043. | 0.411 |
| purH | apt | HMPREF0758_1679 | HMPREF0758_0160 | Phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; COG: COG0138; Pfam: PF02142,PF01808; InterPro: IPR002695. | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | 0.957 |