| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| CsrD | EFE94894.1 | HMPREF0758_1814 | HMPREF0758_3328 | Diguanylate cyclase (GGDEF) domain protein; Pfam: PF00990,PF00563; InterPro: IPR001633. | Cyclic diguanylate phosphodiesterase (EAL) domain protein; COG: COG2200; Pfam: PF00563; InterPro: IPR001633. | 0.496 |
| CsrD | YhjH | HMPREF0758_1814 | HMPREF0758_4626 | Diguanylate cyclase (GGDEF) domain protein; Pfam: PF00990,PF00563; InterPro: IPR001633. | Cyclic diguanylate phosphodiesterase (EAL) domain protein; Pfam: PF00563. | 0.744 |
| CsrD | fis | HMPREF0758_1814 | HMPREF0758_1803 | Diguanylate cyclase (GGDEF) domain protein; Pfam: PF00990,PF00563; InterPro: IPR001633. | DNA-binding protein Fis; Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters; Belongs to the transcriptional regulatory Fis family. | 0.580 |
| CsrD | rtn | HMPREF0758_1814 | HMPREF0758_2870 | Diguanylate cyclase (GGDEF) domain protein; Pfam: PF00990,PF00563; InterPro: IPR001633. | Cyclic diguanylate phosphodiesterase (EAL) domain protein; COG: COG2200; Pfam: PF00563; InterPro: IPR001633. | 0.799 |
| EFE94387.1 | fis | HMPREF0758_3961 | HMPREF0758_1803 | Hypothetical protein. | DNA-binding protein Fis; Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters; Belongs to the transcriptional regulatory Fis family. | 0.555 |
| EFE94387.1 | rtn2 | HMPREF0758_3961 | HMPREF0758_3962 | Hypothetical protein. | EAL domain-containing family protein; COG: COG2200. | 0.773 |
| EFE94894.1 | CsrD | HMPREF0758_3328 | HMPREF0758_1814 | Cyclic diguanylate phosphodiesterase (EAL) domain protein; COG: COG2200; Pfam: PF00563; InterPro: IPR001633. | Diguanylate cyclase (GGDEF) domain protein; Pfam: PF00990,PF00563; InterPro: IPR001633. | 0.496 |
| EFE94894.1 | fis | HMPREF0758_3328 | HMPREF0758_1803 | Cyclic diguanylate phosphodiesterase (EAL) domain protein; COG: COG2200; Pfam: PF00563; InterPro: IPR001633. | DNA-binding protein Fis; Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters; Belongs to the transcriptional regulatory Fis family. | 0.555 |
| YhjH | CsrD | HMPREF0758_4626 | HMPREF0758_1814 | Cyclic diguanylate phosphodiesterase (EAL) domain protein; Pfam: PF00563. | Diguanylate cyclase (GGDEF) domain protein; Pfam: PF00990,PF00563; InterPro: IPR001633. | 0.744 |
| YhjH | fis | HMPREF0758_4626 | HMPREF0758_1803 | Cyclic diguanylate phosphodiesterase (EAL) domain protein; Pfam: PF00563. | DNA-binding protein Fis; Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters; Belongs to the transcriptional regulatory Fis family. | 0.555 |
| dusA | fis | HMPREF0758_1772 | HMPREF0758_1803 | tRNA dihydrouridine synthase A; Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines. Specifically modifies U20 and U20a in tRNAs; Belongs to the Dus family. DusA subfamily. | DNA-binding protein Fis; Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters; Belongs to the transcriptional regulatory Fis family. | 0.674 |
| dusB | fis | HMPREF0758_1804 | HMPREF0758_1803 | TIM-barrel protein, nifR3 family; Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines; Belongs to the Dus family. DusB subfamily. | DNA-binding protein Fis; Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters; Belongs to the transcriptional regulatory Fis family. | 0.957 |
| dusC | fis | HMPREF0758_4775 | HMPREF0758_1803 | Dihydrouridine synthase (Dus); Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines. Specifically modifies U16 in tRNAs. Belongs to the Dus family. DusC subfamily. | DNA-binding protein Fis; Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters; Belongs to the transcriptional regulatory Fis family. | 0.674 |
| fis | CsrD | HMPREF0758_1803 | HMPREF0758_1814 | DNA-binding protein Fis; Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters; Belongs to the transcriptional regulatory Fis family. | Diguanylate cyclase (GGDEF) domain protein; Pfam: PF00990,PF00563; InterPro: IPR001633. | 0.580 |
| fis | EFE94387.1 | HMPREF0758_1803 | HMPREF0758_3961 | DNA-binding protein Fis; Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters; Belongs to the transcriptional regulatory Fis family. | Hypothetical protein. | 0.555 |
| fis | EFE94894.1 | HMPREF0758_1803 | HMPREF0758_3328 | DNA-binding protein Fis; Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters; Belongs to the transcriptional regulatory Fis family. | Cyclic diguanylate phosphodiesterase (EAL) domain protein; COG: COG2200; Pfam: PF00563; InterPro: IPR001633. | 0.555 |
| fis | YhjH | HMPREF0758_1803 | HMPREF0758_4626 | DNA-binding protein Fis; Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters; Belongs to the transcriptional regulatory Fis family. | Cyclic diguanylate phosphodiesterase (EAL) domain protein; Pfam: PF00563. | 0.555 |
| fis | dusA | HMPREF0758_1803 | HMPREF0758_1772 | DNA-binding protein Fis; Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters; Belongs to the transcriptional regulatory Fis family. | tRNA dihydrouridine synthase A; Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines. Specifically modifies U20 and U20a in tRNAs; Belongs to the Dus family. DusA subfamily. | 0.674 |
| fis | dusB | HMPREF0758_1803 | HMPREF0758_1804 | DNA-binding protein Fis; Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters; Belongs to the transcriptional regulatory Fis family. | TIM-barrel protein, nifR3 family; Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines; Belongs to the Dus family. DusB subfamily. | 0.957 |
| fis | dusC | HMPREF0758_1803 | HMPREF0758_4775 | DNA-binding protein Fis; Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters; Belongs to the transcriptional regulatory Fis family. | Dihydrouridine synthase (Dus); Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines. Specifically modifies U16 in tRNAs. Belongs to the Dus family. DusC subfamily. | 0.674 |