| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| fumB | fumC | HMPREF0758_2124 | HMPREF0758_3834 | Hydrolyase, tartrate beta subunit/fumarate domain protein, Fe-S type; Catalyzes the reversible hydration of fumarate to (S)-malate. Belongs to the class-I fumarase family. | Fumarate hydratase, class II; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily. | 0.966 |
| fumB | gabD | HMPREF0758_2124 | HMPREF0758_1828 | Hydrolyase, tartrate beta subunit/fumarate domain protein, Fe-S type; Catalyzes the reversible hydration of fumarate to (S)-malate. Belongs to the class-I fumarase family. | Succinate-semialdehyde dehydrogenase; COG: COG1012; Pfam: PF00171; InterPro: IPR015590; Belongs to the aldehyde dehydrogenase family. | 0.827 |
| fumB | gltA | HMPREF0758_2124 | HMPREF0758_4848 | Hydrolyase, tartrate beta subunit/fumarate domain protein, Fe-S type; Catalyzes the reversible hydration of fumarate to (S)-malate. Belongs to the class-I fumarase family. | Citrate (Si)-synthase; COG: COG0372; Pfam: PF00285; InterPro: IPR010953; Belongs to the citrate synthase family. | 0.966 |
| fumB | mqo | HMPREF0758_2124 | HMPREF0758_4619 | Hydrolyase, tartrate beta subunit/fumarate domain protein, Fe-S type; Catalyzes the reversible hydration of fumarate to (S)-malate. Belongs to the class-I fumarase family. | Malate dehydrogenase (quinone); COG: COG0579; Pfam: PF06039; InterPro: IPR006231. | 0.937 |
| fumB | pckA | HMPREF0758_2124 | HMPREF0758_1037 | Hydrolyase, tartrate beta subunit/fumarate domain protein, Fe-S type; Catalyzes the reversible hydration of fumarate to (S)-malate. Belongs to the class-I fumarase family. | Phosphoenolpyruvate carboxykinase (ATP); Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA. Belongs to the phosphoenolpyruvate carboxykinase (ATP) family. | 0.495 |
| fumB | pckA-2 | HMPREF0758_2124 | HMPREF0758_4023 | Hydrolyase, tartrate beta subunit/fumarate domain protein, Fe-S type; Catalyzes the reversible hydration of fumarate to (S)-malate. Belongs to the class-I fumarase family. | Phosphoenolpyruvate carboxykinase (ATP); Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA. Belongs to the phosphoenolpyruvate carboxykinase (ATP) family. | 0.495 |
| fumB | sucA | HMPREF0758_2124 | HMPREF0758_4843 | Hydrolyase, tartrate beta subunit/fumarate domain protein, Fe-S type; Catalyzes the reversible hydration of fumarate to (S)-malate. Belongs to the class-I fumarase family. | Oxoglutarate dehydrogenase (succinyl-transferring), E1 component; COG: COG0567; Pfam: PF00676,PF02779; InterPro: IPR011603. | 0.741 |
| fumC | fumB | HMPREF0758_3834 | HMPREF0758_2124 | Fumarate hydratase, class II; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily. | Hydrolyase, tartrate beta subunit/fumarate domain protein, Fe-S type; Catalyzes the reversible hydration of fumarate to (S)-malate. Belongs to the class-I fumarase family. | 0.966 |
| fumC | gabD | HMPREF0758_3834 | HMPREF0758_1828 | Fumarate hydratase, class II; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily. | Succinate-semialdehyde dehydrogenase; COG: COG1012; Pfam: PF00171; InterPro: IPR015590; Belongs to the aldehyde dehydrogenase family. | 0.820 |
| fumC | gltA | HMPREF0758_3834 | HMPREF0758_4848 | Fumarate hydratase, class II; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily. | Citrate (Si)-synthase; COG: COG0372; Pfam: PF00285; InterPro: IPR010953; Belongs to the citrate synthase family. | 0.919 |
| fumC | mqo | HMPREF0758_3834 | HMPREF0758_4619 | Fumarate hydratase, class II; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily. | Malate dehydrogenase (quinone); COG: COG0579; Pfam: PF06039; InterPro: IPR006231. | 0.924 |
| fumC | sucA | HMPREF0758_3834 | HMPREF0758_4843 | Fumarate hydratase, class II; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily. | Oxoglutarate dehydrogenase (succinyl-transferring), E1 component; COG: COG0567; Pfam: PF00676,PF02779; InterPro: IPR011603. | 0.637 |
| gabD | fumB | HMPREF0758_1828 | HMPREF0758_2124 | Succinate-semialdehyde dehydrogenase; COG: COG1012; Pfam: PF00171; InterPro: IPR015590; Belongs to the aldehyde dehydrogenase family. | Hydrolyase, tartrate beta subunit/fumarate domain protein, Fe-S type; Catalyzes the reversible hydration of fumarate to (S)-malate. Belongs to the class-I fumarase family. | 0.827 |
| gabD | fumC | HMPREF0758_1828 | HMPREF0758_3834 | Succinate-semialdehyde dehydrogenase; COG: COG1012; Pfam: PF00171; InterPro: IPR015590; Belongs to the aldehyde dehydrogenase family. | Fumarate hydratase, class II; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily. | 0.820 |
| gabD | gabT | HMPREF0758_1828 | HMPREF0758_1915 | Succinate-semialdehyde dehydrogenase; COG: COG1012; Pfam: PF00171; InterPro: IPR015590; Belongs to the aldehyde dehydrogenase family. | 4-aminobutyrate transaminase; COG: COG0160; Pfam: PF00202; InterPro: IPR004632; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. | 0.918 |
| gabD | gabT-2 | HMPREF0758_1828 | HMPREF0758_3780 | Succinate-semialdehyde dehydrogenase; COG: COG1012; Pfam: PF00171; InterPro: IPR015590; Belongs to the aldehyde dehydrogenase family. | 4-aminobutyrate transaminase; COG: COG0160; Pfam: PF00202; InterPro: IPR004632; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. | 0.918 |
| gabD | gltA | HMPREF0758_1828 | HMPREF0758_4848 | Succinate-semialdehyde dehydrogenase; COG: COG1012; Pfam: PF00171; InterPro: IPR015590; Belongs to the aldehyde dehydrogenase family. | Citrate (Si)-synthase; COG: COG0372; Pfam: PF00285; InterPro: IPR010953; Belongs to the citrate synthase family. | 0.867 |
| gabD | hpaI | HMPREF0758_1828 | HMPREF0758_0652 | Succinate-semialdehyde dehydrogenase; COG: COG1012; Pfam: PF00171; InterPro: IPR015590; Belongs to the aldehyde dehydrogenase family. | 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase; COG: COG3836; Pfam: PF03328; InterPro: IPR015813; Belongs to the HpcH/HpaI aldolase family. | 0.904 |
| gabD | mqo | HMPREF0758_1828 | HMPREF0758_4619 | Succinate-semialdehyde dehydrogenase; COG: COG1012; Pfam: PF00171; InterPro: IPR015590; Belongs to the aldehyde dehydrogenase family. | Malate dehydrogenase (quinone); COG: COG0579; Pfam: PF06039; InterPro: IPR006231. | 0.823 |
| gabD | pckA | HMPREF0758_1828 | HMPREF0758_1037 | Succinate-semialdehyde dehydrogenase; COG: COG1012; Pfam: PF00171; InterPro: IPR015590; Belongs to the aldehyde dehydrogenase family. | Phosphoenolpyruvate carboxykinase (ATP); Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA. Belongs to the phosphoenolpyruvate carboxykinase (ATP) family. | 0.855 |