| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| EFE93907.1 | rapZ | HMPREF0758_4791 | HMPREF0758_1848 | Hypothetical protein; Required for morphogenesis under gluconeogenic growth conditions; Belongs to the gluconeogenesis factor family. | Hypothetical protein; Modulates the synthesis of GlmS, by affecting the processing and stability of the regulatory small RNA GlmZ. When glucosamine-6- phosphate (GlcN6P) concentrations are high in the cell, RapZ binds GlmZ and targets it to cleavage by RNase E. Consequently, GlmZ is inactivated and unable to activate GlmS synthesis. Under low GlcN6P concentrations, RapZ is sequestered and inactivated by an other regulatory small RNA, GlmY, preventing GlmZ degradation and leading to synthesis of GlmS; Belongs to the RapZ-like family. RapZ subfamily. | 0.826 |
| Rne | ptsN | HMPREF0758_4195 | HMPREF0758_1849 | Hypothetical protein; 3.1.4.-. | PTS IIA-like nitrogen-regulatory protein PtsN; COG: COG1762; Pfam: PF00359; InterPro: IPR002178. | 0.520 |
| Rne | rapZ | HMPREF0758_4195 | HMPREF0758_1848 | Hypothetical protein; 3.1.4.-. | Hypothetical protein; Modulates the synthesis of GlmS, by affecting the processing and stability of the regulatory small RNA GlmZ. When glucosamine-6- phosphate (GlcN6P) concentrations are high in the cell, RapZ binds GlmZ and targets it to cleavage by RNase E. Consequently, GlmZ is inactivated and unable to activate GlmS synthesis. Under low GlcN6P concentrations, RapZ is sequestered and inactivated by an other regulatory small RNA, GlmY, preventing GlmZ degradation and leading to synthesis of GlmS; Belongs to the RapZ-like family. RapZ subfamily. | 0.709 |
| cafA | rapZ | HMPREF0758_1819 | HMPREF0758_1848 | S1 RNA binding domain protein; COG: COG1530; Pfam: PF00575; InterPro: IPR004659. | Hypothetical protein; Modulates the synthesis of GlmS, by affecting the processing and stability of the regulatory small RNA GlmZ. When glucosamine-6- phosphate (GlcN6P) concentrations are high in the cell, RapZ binds GlmZ and targets it to cleavage by RNase E. Consequently, GlmZ is inactivated and unable to activate GlmS synthesis. Under low GlcN6P concentrations, RapZ is sequestered and inactivated by an other regulatory small RNA, GlmY, preventing GlmZ degradation and leading to synthesis of GlmS; Belongs to the RapZ-like family. RapZ subfamily. | 0.728 |
| glmM | ptsP | HMPREF0758_0808 | HMPREF0758_1627 | Phosphoglucosamine mutase; Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate; Belongs to the phosphohexose mutase family. | Phosphoenolpyruvate-protein phosphotransferase; COG: COG1080; Pfam: PF00381,PF05524,PF00391,PF02896,PF00359; InterPro: IPR006318. | 0.509 |
| glmM | rapZ | HMPREF0758_0808 | HMPREF0758_1848 | Phosphoglucosamine mutase; Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate; Belongs to the phosphohexose mutase family. | Hypothetical protein; Modulates the synthesis of GlmS, by affecting the processing and stability of the regulatory small RNA GlmZ. When glucosamine-6- phosphate (GlcN6P) concentrations are high in the cell, RapZ binds GlmZ and targets it to cleavage by RNase E. Consequently, GlmZ is inactivated and unable to activate GlmS synthesis. Under low GlcN6P concentrations, RapZ is sequestered and inactivated by an other regulatory small RNA, GlmY, preventing GlmZ degradation and leading to synthesis of GlmS; Belongs to the RapZ-like family. RapZ subfamily. | 0.655 |
| licR | rapZ | HMPREF0758_1846 | HMPREF0758_1848 | PRD domain protein; COG: COG3711; Pfam: PF08279,PF05043,PF00874,PF00359; InterPro: IPR002178. | Hypothetical protein; Modulates the synthesis of GlmS, by affecting the processing and stability of the regulatory small RNA GlmZ. When glucosamine-6- phosphate (GlcN6P) concentrations are high in the cell, RapZ binds GlmZ and targets it to cleavage by RNase E. Consequently, GlmZ is inactivated and unable to activate GlmS synthesis. Under low GlcN6P concentrations, RapZ is sequestered and inactivated by an other regulatory small RNA, GlmY, preventing GlmZ degradation and leading to synthesis of GlmS; Belongs to the RapZ-like family. RapZ subfamily. | 0.537 |
| licR | sgcA | HMPREF0758_1846 | HMPREF0758_2774 | PRD domain protein; COG: COG3711; Pfam: PF08279,PF05043,PF00874,PF00359; InterPro: IPR002178. | Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2; COG: COG1762; Pfam: PF00359; InterPro: IPR002178. | 0.528 |
| ptsN | Rne | HMPREF0758_1849 | HMPREF0758_4195 | PTS IIA-like nitrogen-regulatory protein PtsN; COG: COG1762; Pfam: PF00359; InterPro: IPR002178. | Hypothetical protein; 3.1.4.-. | 0.520 |
| ptsN | ptsO | HMPREF0758_1849 | HMPREF0758_1847 | PTS IIA-like nitrogen-regulatory protein PtsN; COG: COG1762; Pfam: PF00359; InterPro: IPR002178. | Phosphocarrier protein NPr; COG: COG1925; Pfam: PF00381; InterPro: IPR000032. | 0.894 |
| ptsN | ptsP | HMPREF0758_1849 | HMPREF0758_1627 | PTS IIA-like nitrogen-regulatory protein PtsN; COG: COG1762; Pfam: PF00359; InterPro: IPR002178. | Phosphoenolpyruvate-protein phosphotransferase; COG: COG1080; Pfam: PF00381,PF05524,PF00391,PF02896,PF00359; InterPro: IPR006318. | 0.726 |
| ptsN | raiA-2 | HMPREF0758_1849 | HMPREF0758_1850 | PTS IIA-like nitrogen-regulatory protein PtsN; COG: COG1762; Pfam: PF00359; InterPro: IPR002178. | Ribosomal subunit interface protein; COG: COG1544; Pfam: PF02482; InterPro: IPR003489. | 0.833 |
| ptsN | rapZ | HMPREF0758_1849 | HMPREF0758_1848 | PTS IIA-like nitrogen-regulatory protein PtsN; COG: COG1762; Pfam: PF00359; InterPro: IPR002178. | Hypothetical protein; Modulates the synthesis of GlmS, by affecting the processing and stability of the regulatory small RNA GlmZ. When glucosamine-6- phosphate (GlcN6P) concentrations are high in the cell, RapZ binds GlmZ and targets it to cleavage by RNase E. Consequently, GlmZ is inactivated and unable to activate GlmS synthesis. Under low GlcN6P concentrations, RapZ is sequestered and inactivated by an other regulatory small RNA, GlmY, preventing GlmZ degradation and leading to synthesis of GlmS; Belongs to the RapZ-like family. RapZ subfamily. | 0.865 |
| ptsO | ptsN | HMPREF0758_1847 | HMPREF0758_1849 | Phosphocarrier protein NPr; COG: COG1925; Pfam: PF00381; InterPro: IPR000032. | PTS IIA-like nitrogen-regulatory protein PtsN; COG: COG1762; Pfam: PF00359; InterPro: IPR002178. | 0.894 |
| ptsO | ptsP | HMPREF0758_1847 | HMPREF0758_1627 | Phosphocarrier protein NPr; COG: COG1925; Pfam: PF00381; InterPro: IPR000032. | Phosphoenolpyruvate-protein phosphotransferase; COG: COG1080; Pfam: PF00381,PF05524,PF00391,PF02896,PF00359; InterPro: IPR006318. | 0.915 |
| ptsO | raiA-2 | HMPREF0758_1847 | HMPREF0758_1850 | Phosphocarrier protein NPr; COG: COG1925; Pfam: PF00381; InterPro: IPR000032. | Ribosomal subunit interface protein; COG: COG1544; Pfam: PF02482; InterPro: IPR003489. | 0.480 |
| ptsO | rapZ | HMPREF0758_1847 | HMPREF0758_1848 | Phosphocarrier protein NPr; COG: COG1925; Pfam: PF00381; InterPro: IPR000032. | Hypothetical protein; Modulates the synthesis of GlmS, by affecting the processing and stability of the regulatory small RNA GlmZ. When glucosamine-6- phosphate (GlcN6P) concentrations are high in the cell, RapZ binds GlmZ and targets it to cleavage by RNase E. Consequently, GlmZ is inactivated and unable to activate GlmS synthesis. Under low GlcN6P concentrations, RapZ is sequestered and inactivated by an other regulatory small RNA, GlmY, preventing GlmZ degradation and leading to synthesis of GlmS; Belongs to the RapZ-like family. RapZ subfamily. | 0.862 |
| ptsP | glmM | HMPREF0758_1627 | HMPREF0758_0808 | Phosphoenolpyruvate-protein phosphotransferase; COG: COG1080; Pfam: PF00381,PF05524,PF00391,PF02896,PF00359; InterPro: IPR006318. | Phosphoglucosamine mutase; Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate; Belongs to the phosphohexose mutase family. | 0.509 |
| ptsP | ptsN | HMPREF0758_1627 | HMPREF0758_1849 | Phosphoenolpyruvate-protein phosphotransferase; COG: COG1080; Pfam: PF00381,PF05524,PF00391,PF02896,PF00359; InterPro: IPR006318. | PTS IIA-like nitrogen-regulatory protein PtsN; COG: COG1762; Pfam: PF00359; InterPro: IPR002178. | 0.726 |
| ptsP | ptsO | HMPREF0758_1627 | HMPREF0758_1847 | Phosphoenolpyruvate-protein phosphotransferase; COG: COG1080; Pfam: PF00381,PF05524,PF00391,PF02896,PF00359; InterPro: IPR006318. | Phosphocarrier protein NPr; COG: COG1925; Pfam: PF00381; InterPro: IPR000032. | 0.915 |