| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| OsmY_3 | diaA | HMPREF0758_1883 | HMPREF0758_1884 | Phospholipid-binding domain protein; COG: COG2823; Pfam: PF04972; InterPro: IPR007055. | DnaA initiator-associating protein DiaA; Required for the timely initiation of chromosomal replication via direct interactions with the DnaA initiator protein. Belongs to the SIS family. DiaA subfamily. | 0.780 |
| OsmY_3 | lpoA | HMPREF0758_1883 | HMPREF0758_1886 | Phospholipid-binding domain protein; COG: COG2823; Pfam: PF04972; InterPro: IPR007055. | LppC; Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1A (PBP1a). Belongs to the LpoA family. | 0.609 |
| OsmY_3 | yraN | HMPREF0758_1883 | HMPREF0758_1885 | Phospholipid-binding domain protein; COG: COG2823; Pfam: PF04972; InterPro: IPR007055. | TIGR00252 family protein; COG: COG0792; Pfam: PF02021; InterPro: IPR003509; Belongs to the UPF0102 family. | 0.617 |
| RfaF_2 | diaA | HMPREF0758_1252 | HMPREF0758_1884 | Heptosyltransferase; Pfam: PF01075; InterPro: IPR002201. | DnaA initiator-associating protein DiaA; Required for the timely initiation of chromosomal replication via direct interactions with the DnaA initiator protein. Belongs to the SIS family. DiaA subfamily. | 0.741 |
| RfaF_2 | gmhB | HMPREF0758_1252 | HMPREF0758_2369 | Heptosyltransferase; Pfam: PF01075; InterPro: IPR002201. | D,D-heptose 1,7-bisphosphate phosphatase; COG: COG0241; Pfam: PF00702; InterPro: IPR004446. | 0.754 |
| RfaF_2 | rfaD | HMPREF0758_1252 | HMPREF0758_1246 | Heptosyltransferase; Pfam: PF01075; InterPro: IPR002201. | ADP-glyceromanno-heptose 6-epimerase; Catalyzes the interconversion between ADP-D-glycero-beta-D- manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose; Belongs to the NAD(P)-dependent epimerase/dehydratase family. HldD subfamily. | 0.524 |
| RfaF_2 | rfaE | HMPREF0758_1252 | HMPREF0758_1943 | Heptosyltransferase; Pfam: PF01075; InterPro: IPR002201. | Bifunctional protein RfaE, domain I; Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno-heptose. In the N-terminal section; belongs to the carbohydrate kinase PfkB family. | 0.783 |
| RfaF_2 | rfaF | HMPREF0758_1252 | HMPREF0758_1247 | Heptosyltransferase; Pfam: PF01075; InterPro: IPR002201. | Lipopolysaccharide heptosyltransferase II; COG: COG0859; Pfam: PF01075; InterPro: IPR011910. | 0.612 |
| RfaQ_2 | diaA | HMPREF0758_1258 | HMPREF0758_1884 | Heptosyltransferase; Pfam: PF01075; InterPro: IPR002201. | DnaA initiator-associating protein DiaA; Required for the timely initiation of chromosomal replication via direct interactions with the DnaA initiator protein. Belongs to the SIS family. DiaA subfamily. | 0.677 |
| RfaQ_2 | gmhB | HMPREF0758_1258 | HMPREF0758_2369 | Heptosyltransferase; Pfam: PF01075; InterPro: IPR002201. | D,D-heptose 1,7-bisphosphate phosphatase; COG: COG0241; Pfam: PF00702; InterPro: IPR004446. | 0.697 |
| RfaQ_2 | rfaD | HMPREF0758_1258 | HMPREF0758_1246 | Heptosyltransferase; Pfam: PF01075; InterPro: IPR002201. | ADP-glyceromanno-heptose 6-epimerase; Catalyzes the interconversion between ADP-D-glycero-beta-D- manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose; Belongs to the NAD(P)-dependent epimerase/dehydratase family. HldD subfamily. | 0.411 |
| RfaQ_2 | rfaE | HMPREF0758_1258 | HMPREF0758_1943 | Heptosyltransferase; Pfam: PF01075; InterPro: IPR002201. | Bifunctional protein RfaE, domain I; Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno-heptose. In the N-terminal section; belongs to the carbohydrate kinase PfkB family. | 0.756 |
| RfaQ_2 | rfaF | HMPREF0758_1258 | HMPREF0758_1247 | Heptosyltransferase; Pfam: PF01075; InterPro: IPR002201. | Lipopolysaccharide heptosyltransferase II; COG: COG0859; Pfam: PF01075; InterPro: IPR011910. | 0.983 |
| diaA | OsmY_3 | HMPREF0758_1884 | HMPREF0758_1883 | DnaA initiator-associating protein DiaA; Required for the timely initiation of chromosomal replication via direct interactions with the DnaA initiator protein. Belongs to the SIS family. DiaA subfamily. | Phospholipid-binding domain protein; COG: COG2823; Pfam: PF04972; InterPro: IPR007055. | 0.780 |
| diaA | RfaF_2 | HMPREF0758_1884 | HMPREF0758_1252 | DnaA initiator-associating protein DiaA; Required for the timely initiation of chromosomal replication via direct interactions with the DnaA initiator protein. Belongs to the SIS family. DiaA subfamily. | Heptosyltransferase; Pfam: PF01075; InterPro: IPR002201. | 0.741 |
| diaA | RfaQ_2 | HMPREF0758_1884 | HMPREF0758_1258 | DnaA initiator-associating protein DiaA; Required for the timely initiation of chromosomal replication via direct interactions with the DnaA initiator protein. Belongs to the SIS family. DiaA subfamily. | Heptosyltransferase; Pfam: PF01075; InterPro: IPR002201. | 0.677 |
| diaA | gmhB | HMPREF0758_1884 | HMPREF0758_2369 | DnaA initiator-associating protein DiaA; Required for the timely initiation of chromosomal replication via direct interactions with the DnaA initiator protein. Belongs to the SIS family. DiaA subfamily. | D,D-heptose 1,7-bisphosphate phosphatase; COG: COG0241; Pfam: PF00702; InterPro: IPR004446. | 0.957 |
| diaA | hisB | HMPREF0758_1884 | HMPREF0758_4536 | DnaA initiator-associating protein DiaA; Required for the timely initiation of chromosomal replication via direct interactions with the DnaA initiator protein. Belongs to the SIS family. DiaA subfamily. | Histidinol-phosphatase; COG: COG0131; Pfam: PF08645,PF00475; InterPro: IPR000807; In the N-terminal section; belongs to the histidinol- phosphatase family. | 0.761 |
| diaA | lpoA | HMPREF0758_1884 | HMPREF0758_1886 | DnaA initiator-associating protein DiaA; Required for the timely initiation of chromosomal replication via direct interactions with the DnaA initiator protein. Belongs to the SIS family. DiaA subfamily. | LppC; Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1A (PBP1a). Belongs to the LpoA family. | 0.695 |
| diaA | rfaD | HMPREF0758_1884 | HMPREF0758_1246 | DnaA initiator-associating protein DiaA; Required for the timely initiation of chromosomal replication via direct interactions with the DnaA initiator protein. Belongs to the SIS family. DiaA subfamily. | ADP-glyceromanno-heptose 6-epimerase; Catalyzes the interconversion between ADP-D-glycero-beta-D- manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose; Belongs to the NAD(P)-dependent epimerase/dehydratase family. HldD subfamily. | 0.698 |