| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| EFE96480.1 | guaA | HMPREF0758_1909 | HMPREF0758_1907 | Hypothetical protein; COG: COG1451; Pfam: PF01863. | Class I glutamine amidotransferase; COG: COG0518; Pfam: PF00117; InterPro: IPR000991. | 0.741 |
| EFE96480.1 | mviM | HMPREF0758_1909 | HMPREF0758_1908 | Hypothetical protein; COG: COG1451; Pfam: PF01863. | Oxidoreductase, NAD-binding domain protein; COG: COG0673; Pfam: PF01408; InterPro: IPR016040. | 0.747 |
| EFE96480.1 | ygjO | HMPREF0758_1909 | HMPREF0758_1910 | Hypothetical protein; COG: COG1451; Pfam: PF01863. | Methyltransferase small domain protein; Specifically methylates the guanine in position 1835 (m2G1835) of 23S rRNA. | 0.640 |
| ccmD | ygjO | HMPREF0758_2712 | HMPREF0758_1910 | Heme exporter protein CcmD; Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes; Belongs to the CcmD/CycX/HelD family. | Methyltransferase small domain protein; Specifically methylates the guanine in position 1835 (m2G1835) of 23S rRNA. | 0.450 |
| cgtA | ygjO | HMPREF0758_0817 | HMPREF0758_1910 | Obg family GTPase CgtA; An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control. Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. | Methyltransferase small domain protein; Specifically methylates the guanine in position 1835 (m2G1835) of 23S rRNA. | 0.517 |
| guaA | EFE96480.1 | HMPREF0758_1907 | HMPREF0758_1909 | Class I glutamine amidotransferase; COG: COG0518; Pfam: PF00117; InterPro: IPR000991. | Hypothetical protein; COG: COG1451; Pfam: PF01863. | 0.741 |
| guaA | mviM | HMPREF0758_1907 | HMPREF0758_1908 | Class I glutamine amidotransferase; COG: COG0518; Pfam: PF00117; InterPro: IPR000991. | Oxidoreductase, NAD-binding domain protein; COG: COG0673; Pfam: PF01408; InterPro: IPR016040. | 0.781 |
| guaA | ygjO | HMPREF0758_1907 | HMPREF0758_1910 | Class I glutamine amidotransferase; COG: COG0518; Pfam: PF00117; InterPro: IPR000991. | Methyltransferase small domain protein; Specifically methylates the guanine in position 1835 (m2G1835) of 23S rRNA. | 0.533 |
| mviM | EFE96480.1 | HMPREF0758_1908 | HMPREF0758_1909 | Oxidoreductase, NAD-binding domain protein; COG: COG0673; Pfam: PF01408; InterPro: IPR016040. | Hypothetical protein; COG: COG1451; Pfam: PF01863. | 0.747 |
| mviM | guaA | HMPREF0758_1908 | HMPREF0758_1907 | Oxidoreductase, NAD-binding domain protein; COG: COG0673; Pfam: PF01408; InterPro: IPR016040. | Class I glutamine amidotransferase; COG: COG0518; Pfam: PF00117; InterPro: IPR000991. | 0.781 |
| mviM | ygjO | HMPREF0758_1908 | HMPREF0758_1910 | Oxidoreductase, NAD-binding domain protein; COG: COG0673; Pfam: PF01408; InterPro: IPR016040. | Methyltransferase small domain protein; Specifically methylates the guanine in position 1835 (m2G1835) of 23S rRNA. | 0.578 |
| rapA | ygjO | HMPREF0758_0547 | HMPREF0758_1910 | ATP-dependent helicase HepA; Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair; Belongs to the SNF2/RAD54 helicase family. RapA subfamily. | Methyltransferase small domain protein; Specifically methylates the guanine in position 1835 (m2G1835) of 23S rRNA. | 0.473 |
| rlmL | rsmF | HMPREF0758_4349 | HMPREF0758_4017 | THUMP domain protein; Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA. Belongs to the methyltransferase superfamily. RlmKL family. | NOL1/NOP2/sun family protein; Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA. | 0.649 |
| rlmL | ygjO | HMPREF0758_4349 | HMPREF0758_1910 | THUMP domain protein; Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA. Belongs to the methyltransferase superfamily. RlmKL family. | Methyltransferase small domain protein; Specifically methylates the guanine in position 1835 (m2G1835) of 23S rRNA. | 0.461 |
| rsmF | rlmL | HMPREF0758_4017 | HMPREF0758_4349 | NOL1/NOP2/sun family protein; Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA. | THUMP domain protein; Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA. Belongs to the methyltransferase superfamily. RlmKL family. | 0.649 |
| rsmF | ygjO | HMPREF0758_4017 | HMPREF0758_1910 | NOL1/NOP2/sun family protein; Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA. | Methyltransferase small domain protein; Specifically methylates the guanine in position 1835 (m2G1835) of 23S rRNA. | 0.427 |
| tdk | ygjO | HMPREF0758_3516 | HMPREF0758_1910 | Thymidine kinase; COG: COG1435; Pfam: PF00265; InterPro: IPR001267. | Methyltransferase small domain protein; Specifically methylates the guanine in position 1835 (m2G1835) of 23S rRNA. | 0.447 |
| ygjO | EFE96480.1 | HMPREF0758_1910 | HMPREF0758_1909 | Methyltransferase small domain protein; Specifically methylates the guanine in position 1835 (m2G1835) of 23S rRNA. | Hypothetical protein; COG: COG1451; Pfam: PF01863. | 0.640 |
| ygjO | ccmD | HMPREF0758_1910 | HMPREF0758_2712 | Methyltransferase small domain protein; Specifically methylates the guanine in position 1835 (m2G1835) of 23S rRNA. | Heme exporter protein CcmD; Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes; Belongs to the CcmD/CycX/HelD family. | 0.450 |
| ygjO | cgtA | HMPREF0758_1910 | HMPREF0758_0817 | Methyltransferase small domain protein; Specifically methylates the guanine in position 1835 (m2G1835) of 23S rRNA. | Obg family GTPase CgtA; An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control. Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. | 0.517 |