| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| EFE96528.1 | EFE96530.1 | HMPREF0758_1957 | HMPREF0758_1959 | Hypothetical protein; COG: COG3151; Pfam: PF06853; InterPro: IPR009659. | Hypothetical protein; COG: COG3150; Pfam: PF05728; InterPro: IPR008886. | 0.576 |
| EFE96528.1 | cpdA | HMPREF0758_1957 | HMPREF0758_1958 | Hypothetical protein; COG: COG3151; Pfam: PF06853; InterPro: IPR009659. | Ser/Thr phosphatase family protein; Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes. | 0.555 |
| EFE96528.1 | nudF | HMPREF0758_1957 | HMPREF0758_1956 | Hypothetical protein; COG: COG3151; Pfam: PF06853; InterPro: IPR009659. | ADP-ribose pyrophosphatase; COG: COG0494; Pfam: PF00293; InterPro: IPR000086. | 0.854 |
| EFE96528.1 | tolC | HMPREF0758_1957 | HMPREF0758_1955 | Hypothetical protein; COG: COG3151; Pfam: PF06853; InterPro: IPR009659. | Type I secretion outer membrane protein, TolC family; COG: COG1538; Pfam: PF02321; InterPro: IPR010130. | 0.529 |
| EFE96530.1 | EFE96528.1 | HMPREF0758_1959 | HMPREF0758_1957 | Hypothetical protein; COG: COG3150; Pfam: PF05728; InterPro: IPR008886. | Hypothetical protein; COG: COG3151; Pfam: PF06853; InterPro: IPR009659. | 0.576 |
| EFE96530.1 | cpdA | HMPREF0758_1959 | HMPREF0758_1958 | Hypothetical protein; COG: COG3150; Pfam: PF05728; InterPro: IPR008886. | Ser/Thr phosphatase family protein; Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes. | 0.875 |
| EFE96530.1 | nudF | HMPREF0758_1959 | HMPREF0758_1956 | Hypothetical protein; COG: COG3150; Pfam: PF05728; InterPro: IPR008886. | ADP-ribose pyrophosphatase; COG: COG0494; Pfam: PF00293; InterPro: IPR000086. | 0.505 |
| EFE96530.1 | tolC | HMPREF0758_1959 | HMPREF0758_1955 | Hypothetical protein; COG: COG3150; Pfam: PF05728; InterPro: IPR008886. | Type I secretion outer membrane protein, TolC family; COG: COG1538; Pfam: PF02321; InterPro: IPR010130. | 0.575 |
| birA | nudE | HMPREF0758_1652 | HMPREF0758_1032 | biotin--[acetyl-CoA-carboxylase] ligase; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio-5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon. | Hydrolase, NUDIX family; COG: COG0494; Pfam: PF00293; InterPro: IPR000086. | 0.550 |
| birA | nudF | HMPREF0758_1652 | HMPREF0758_1956 | biotin--[acetyl-CoA-carboxylase] ligase; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio-5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon. | ADP-ribose pyrophosphatase; COG: COG0494; Pfam: PF00293; InterPro: IPR000086. | 0.550 |
| birA | prs | HMPREF0758_1652 | HMPREF0758_3388 | biotin--[acetyl-CoA-carboxylase] ligase; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio-5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon. | Ribose-phosphate diphosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. | 0.431 |
| cpdA | EFE96528.1 | HMPREF0758_1958 | HMPREF0758_1957 | Ser/Thr phosphatase family protein; Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes. | Hypothetical protein; COG: COG3151; Pfam: PF06853; InterPro: IPR009659. | 0.555 |
| cpdA | EFE96530.1 | HMPREF0758_1958 | HMPREF0758_1959 | Ser/Thr phosphatase family protein; Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes. | Hypothetical protein; COG: COG3150; Pfam: PF05728; InterPro: IPR008886. | 0.875 |
| cpdA | nudF | HMPREF0758_1958 | HMPREF0758_1956 | Ser/Thr phosphatase family protein; Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes. | ADP-ribose pyrophosphatase; COG: COG0494; Pfam: PF00293; InterPro: IPR000086. | 0.605 |
| cpdA | tolC | HMPREF0758_1958 | HMPREF0758_1955 | Ser/Thr phosphatase family protein; Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes. | Type I secretion outer membrane protein, TolC family; COG: COG1538; Pfam: PF02321; InterPro: IPR010130. | 0.431 |
| deoB | nudE | HMPREF0758_0613 | HMPREF0758_1032 | Phosphopentomutase; Phosphotransfer between the C1 and C5 carbon atoms of pentose; Belongs to the phosphopentomutase family. | Hydrolase, NUDIX family; COG: COG0494; Pfam: PF00293; InterPro: IPR000086. | 0.903 |
| deoB | nudF | HMPREF0758_0613 | HMPREF0758_1956 | Phosphopentomutase; Phosphotransfer between the C1 and C5 carbon atoms of pentose; Belongs to the phosphopentomutase family. | ADP-ribose pyrophosphatase; COG: COG0494; Pfam: PF00293; InterPro: IPR000086. | 0.903 |
| deoB | pgm | HMPREF0758_0613 | HMPREF0758_4874 | Phosphopentomutase; Phosphotransfer between the C1 and C5 carbon atoms of pentose; Belongs to the phosphopentomutase family. | Phosphoglucomutase, alpha-D-glucose phosphate-specific; COG: COG0033; Pfam: PF02878,PF02879,PF02880,PF00408; InterPro: IPR005852. | 0.901 |
| deoB | prs | HMPREF0758_0613 | HMPREF0758_3388 | Phosphopentomutase; Phosphotransfer between the C1 and C5 carbon atoms of pentose; Belongs to the phosphopentomutase family. | Ribose-phosphate diphosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. | 0.917 |
| nudE | birA | HMPREF0758_1032 | HMPREF0758_1652 | Hydrolase, NUDIX family; COG: COG0494; Pfam: PF00293; InterPro: IPR000086. | biotin--[acetyl-CoA-carboxylase] ligase; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio-5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon. | 0.550 |