| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| C1-hpah | hpaC | HMPREF0758_3756 | HMPREF0758_0648 | Flavin reductase-like protein; COG: COG1853; Pfam: PF01613; InterPro: IPR012349. | 4-hydroxyphenylacetate 3-monooxygenase, reductase component; COG: COG1853; Pfam: PF01613; InterPro: IPR002563. | 0.924 |
| C1-hpah | nfsA | HMPREF0758_3756 | HMPREF0758_1971 | Flavin reductase-like protein; COG: COG1853; Pfam: PF01613; InterPro: IPR012349. | Nitroreductase family protein; COG: COG0778; Pfam: PF00881; InterPro: IPR000415; Belongs to the flavin oxidoreductase frp family. | 0.911 |
| C1-hpah | phyM | HMPREF0758_3756 | HMPREF0758_1356 | Flavin reductase-like protein; COG: COG1853; Pfam: PF01613; InterPro: IPR012349. | Histidine acid phosphatase; Pfam: PF00328; InterPro: IPR000560. | 0.900 |
| C1-hpah | ribF | HMPREF0758_3756 | HMPREF0758_0575 | Flavin reductase-like protein; COG: COG1853; Pfam: PF01613; InterPro: IPR012349. | Riboflavin biosynthesis protein RibF; COG: COG0196; Pfam: PF06574,PF01687; InterPro: IPR002606; Belongs to the ribF family. | 0.903 |
| C1-hpah | ssuE | HMPREF0758_3756 | HMPREF0758_4353 | Flavin reductase-like protein; COG: COG1853; Pfam: PF01613; InterPro: IPR012349. | FMN reductase; COG: COG0431; Pfam: PF03358; InterPro: IPR005025. | 0.906 |
| C1-hpah | yigB | HMPREF0758_3756 | HMPREF0758_1538 | Flavin reductase-like protein; COG: COG1853; Pfam: PF01613; InterPro: IPR012349. | HAD hydrolase, family IA, variant 1; COG: COG1011; Pfam: PF00702; InterPro: IPR005834. | 0.900 |
| EFE93552.1 | nfsA | HMPREF0758_4436 | HMPREF0758_1971 | YcaO-like family; COG: COG1944; Pfam: PF02624; InterPro: IPR003776. | Nitroreductase family protein; COG: COG0778; Pfam: PF00881; InterPro: IPR000415; Belongs to the flavin oxidoreductase frp family. | 0.624 |
| EFE93609.1 | nfsA | HMPREF0758_4493 | HMPREF0758_1971 | Hypothetical protein; Pfam: PF07214; InterPro: IPR010815. | Nitroreductase family protein; COG: COG0778; Pfam: PF00881; InterPro: IPR000415; Belongs to the flavin oxidoreductase frp family. | 0.588 |
| birA | nfsA | HMPREF0758_1652 | HMPREF0758_1971 | biotin--[acetyl-CoA-carboxylase] ligase; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio-5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon. | Nitroreductase family protein; COG: COG0778; Pfam: PF00881; InterPro: IPR000415; Belongs to the flavin oxidoreductase frp family. | 0.672 |
| birA | ribF | HMPREF0758_1652 | HMPREF0758_0575 | biotin--[acetyl-CoA-carboxylase] ligase; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio-5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon. | Riboflavin biosynthesis protein RibF; COG: COG0196; Pfam: PF06574,PF01687; InterPro: IPR002606; Belongs to the ribF family. | 0.505 |
| hpaC | C1-hpah | HMPREF0758_0648 | HMPREF0758_3756 | 4-hydroxyphenylacetate 3-monooxygenase, reductase component; COG: COG1853; Pfam: PF01613; InterPro: IPR002563. | Flavin reductase-like protein; COG: COG1853; Pfam: PF01613; InterPro: IPR012349. | 0.924 |
| hpaC | nfsA | HMPREF0758_0648 | HMPREF0758_1971 | 4-hydroxyphenylacetate 3-monooxygenase, reductase component; COG: COG1853; Pfam: PF01613; InterPro: IPR002563. | Nitroreductase family protein; COG: COG0778; Pfam: PF00881; InterPro: IPR000415; Belongs to the flavin oxidoreductase frp family. | 0.911 |
| hpaC | phyM | HMPREF0758_0648 | HMPREF0758_1356 | 4-hydroxyphenylacetate 3-monooxygenase, reductase component; COG: COG1853; Pfam: PF01613; InterPro: IPR002563. | Histidine acid phosphatase; Pfam: PF00328; InterPro: IPR000560. | 0.900 |
| hpaC | ribF | HMPREF0758_0648 | HMPREF0758_0575 | 4-hydroxyphenylacetate 3-monooxygenase, reductase component; COG: COG1853; Pfam: PF01613; InterPro: IPR002563. | Riboflavin biosynthesis protein RibF; COG: COG0196; Pfam: PF06574,PF01687; InterPro: IPR002606; Belongs to the ribF family. | 0.903 |
| hpaC | ssuE | HMPREF0758_0648 | HMPREF0758_4353 | 4-hydroxyphenylacetate 3-monooxygenase, reductase component; COG: COG1853; Pfam: PF01613; InterPro: IPR002563. | FMN reductase; COG: COG0431; Pfam: PF03358; InterPro: IPR005025. | 0.906 |
| hpaC | yigB | HMPREF0758_0648 | HMPREF0758_1538 | 4-hydroxyphenylacetate 3-monooxygenase, reductase component; COG: COG1853; Pfam: PF01613; InterPro: IPR002563. | HAD hydrolase, family IA, variant 1; COG: COG1011; Pfam: PF00702; InterPro: IPR005834. | 0.900 |
| nfsA | C1-hpah | HMPREF0758_1971 | HMPREF0758_3756 | Nitroreductase family protein; COG: COG0778; Pfam: PF00881; InterPro: IPR000415; Belongs to the flavin oxidoreductase frp family. | Flavin reductase-like protein; COG: COG1853; Pfam: PF01613; InterPro: IPR012349. | 0.911 |
| nfsA | EFE93552.1 | HMPREF0758_1971 | HMPREF0758_4436 | Nitroreductase family protein; COG: COG0778; Pfam: PF00881; InterPro: IPR000415; Belongs to the flavin oxidoreductase frp family. | YcaO-like family; COG: COG1944; Pfam: PF02624; InterPro: IPR003776. | 0.624 |
| nfsA | EFE93609.1 | HMPREF0758_1971 | HMPREF0758_4493 | Nitroreductase family protein; COG: COG0778; Pfam: PF00881; InterPro: IPR000415; Belongs to the flavin oxidoreductase frp family. | Hypothetical protein; Pfam: PF07214; InterPro: IPR010815. | 0.588 |
| nfsA | birA | HMPREF0758_1971 | HMPREF0758_1652 | Nitroreductase family protein; COG: COG0778; Pfam: PF00881; InterPro: IPR000415; Belongs to the flavin oxidoreductase frp family. | biotin--[acetyl-CoA-carboxylase] ligase; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio-5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon. | 0.672 |