| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| CzcA | EFE96566.1 | HMPREF0758_1997 | HMPREF0758_1995 | RND transporter, HAE1/HME family, permease protein; COG: COG0841; Pfam: PF00873; InterPro: IPR001036; Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family. | Transcriptional regulator, TetR family; Pfam: PF00440; InterPro: IPR001647. | 0.881 |
| CzcA | MexA | HMPREF0758_1997 | HMPREF0758_1996 | RND transporter, HAE1/HME family, permease protein; COG: COG0841; Pfam: PF00873; InterPro: IPR001036; Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family. | Efflux transporter, RND family, MFP subunit; COG: COG0845; Pfam: PF00529; InterPro: IPR006143; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family. | 0.970 |
| CzcA | macB | HMPREF0758_1997 | HMPREF0758_4460 | RND transporter, HAE1/HME family, permease protein; COG: COG0841; Pfam: PF00873; InterPro: IPR001036; Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family. | ABC transporter, ATP-binding protein; Part of the tripartite efflux system MacAB-TolC. MacB is a non-canonical ABC transporter that contains transmembrane domains (TMD), which form a pore in the inner membrane, and an ATP-binding domain (NBD), which is responsible for energy generation. Confers resistance against macrolides. | 0.412 |
| EFE96566.1 | CzcA | HMPREF0758_1995 | HMPREF0758_1997 | Transcriptional regulator, TetR family; Pfam: PF00440; InterPro: IPR001647. | RND transporter, HAE1/HME family, permease protein; COG: COG0841; Pfam: PF00873; InterPro: IPR001036; Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family. | 0.881 |
| EFE96566.1 | MexA | HMPREF0758_1995 | HMPREF0758_1996 | Transcriptional regulator, TetR family; Pfam: PF00440; InterPro: IPR001647. | Efflux transporter, RND family, MFP subunit; COG: COG0845; Pfam: PF00529; InterPro: IPR006143; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family. | 0.893 |
| MexA | CzcA | HMPREF0758_1996 | HMPREF0758_1997 | Efflux transporter, RND family, MFP subunit; COG: COG0845; Pfam: PF00529; InterPro: IPR006143; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family. | RND transporter, HAE1/HME family, permease protein; COG: COG0841; Pfam: PF00873; InterPro: IPR001036; Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family. | 0.970 |
| MexA | EFE96566.1 | HMPREF0758_1996 | HMPREF0758_1995 | Efflux transporter, RND family, MFP subunit; COG: COG0845; Pfam: PF00529; InterPro: IPR006143; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family. | Transcriptional regulator, TetR family; Pfam: PF00440; InterPro: IPR001647. | 0.893 |
| MexA | OprM | HMPREF0758_1996 | HMPREF0758_2996 | Efflux transporter, RND family, MFP subunit; COG: COG0845; Pfam: PF00529; InterPro: IPR006143; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family. | Efflux transporter, outer membrane factor lipoprotein, NodT family; COG: COG1538; Pfam: PF02321; InterPro: IPR010131. | 0.477 |
| MexA | acrB | HMPREF0758_1996 | HMPREF0758_0172 | Efflux transporter, RND family, MFP subunit; COG: COG0845; Pfam: PF00529; InterPro: IPR006143; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family. | RND transporter, HAE1 family; COG: COG0841; Pfam: PF00873; InterPro: IPR004764. | 0.584 |
| MexA | bpeB | HMPREF0758_1996 | HMPREF0758_2615 | Efflux transporter, RND family, MFP subunit; COG: COG0845; Pfam: PF00529; InterPro: IPR006143; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family. | Putative ATP synthase F0, A subunit; COG: COG0841; Pfam: PF00873; InterPro: IPR004764. | 0.576 |
| MexA | lolD | HMPREF0758_1996 | HMPREF0758_4166 | Efflux transporter, RND family, MFP subunit; COG: COG0845; Pfam: PF00529; InterPro: IPR006143; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family. | Lipoprotein releasing system, ATP-binding protein; Part of the ABC transporter complex LolCDE involved in the translocation of lipoproteins, in an ATP-dependent manner. | 0.477 |
| MexA | macB | HMPREF0758_1996 | HMPREF0758_4460 | Efflux transporter, RND family, MFP subunit; COG: COG0845; Pfam: PF00529; InterPro: IPR006143; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family. | ABC transporter, ATP-binding protein; Part of the tripartite efflux system MacAB-TolC. MacB is a non-canonical ABC transporter that contains transmembrane domains (TMD), which form a pore in the inner membrane, and an ATP-binding domain (NBD), which is responsible for energy generation. Confers resistance against macrolides. | 0.975 |
| MexA | mdtB | HMPREF0758_1996 | HMPREF0758_2571 | Efflux transporter, RND family, MFP subunit; COG: COG0845; Pfam: PF00529; InterPro: IPR006143; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family. | RND transporter, HAE1 family; COG: COG0841; Pfam: PF00873; InterPro: IPR001036; overlaps another CDS with the same product name; Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family. MdtB subfamily. | 0.558 |
| MexA | mdtC | HMPREF0758_1996 | HMPREF0758_2570 | Efflux transporter, RND family, MFP subunit; COG: COG0845; Pfam: PF00529; InterPro: IPR006143; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family. | Putative ATP synthase F0, A subunit; COG: COG0841; Pfam: PF00873; InterPro: IPR001036; Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family. MdtC subfamily. | 0.538 |
| MexA | nifJ | HMPREF0758_1996 | HMPREF0758_3621 | Efflux transporter, RND family, MFP subunit; COG: COG0845; Pfam: PF00529; InterPro: IPR006143; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family. | Pyruvate synthase; COG: COG0674; Pfam: PF01855,PF01558,PF00037,PF02775; InterPro: IPR011895. | 0.638 |
| OprM | MexA | HMPREF0758_2996 | HMPREF0758_1996 | Efflux transporter, outer membrane factor lipoprotein, NodT family; COG: COG1538; Pfam: PF02321; InterPro: IPR010131. | Efflux transporter, RND family, MFP subunit; COG: COG0845; Pfam: PF00529; InterPro: IPR006143; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family. | 0.477 |
| OprM | acrB | HMPREF0758_2996 | HMPREF0758_0172 | Efflux transporter, outer membrane factor lipoprotein, NodT family; COG: COG1538; Pfam: PF02321; InterPro: IPR010131. | RND transporter, HAE1 family; COG: COG0841; Pfam: PF00873; InterPro: IPR004764. | 0.845 |
| OprM | bpeB | HMPREF0758_2996 | HMPREF0758_2615 | Efflux transporter, outer membrane factor lipoprotein, NodT family; COG: COG1538; Pfam: PF02321; InterPro: IPR010131. | Putative ATP synthase F0, A subunit; COG: COG0841; Pfam: PF00873; InterPro: IPR004764. | 0.829 |
| OprM | macB | HMPREF0758_2996 | HMPREF0758_4460 | Efflux transporter, outer membrane factor lipoprotein, NodT family; COG: COG1538; Pfam: PF02321; InterPro: IPR010131. | ABC transporter, ATP-binding protein; Part of the tripartite efflux system MacAB-TolC. MacB is a non-canonical ABC transporter that contains transmembrane domains (TMD), which form a pore in the inner membrane, and an ATP-binding domain (NBD), which is responsible for energy generation. Confers resistance against macrolides. | 0.907 |
| OprM | mdtB | HMPREF0758_2996 | HMPREF0758_2571 | Efflux transporter, outer membrane factor lipoprotein, NodT family; COG: COG1538; Pfam: PF02321; InterPro: IPR010131. | RND transporter, HAE1 family; COG: COG0841; Pfam: PF00873; InterPro: IPR001036; overlaps another CDS with the same product name; Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family. MdtB subfamily. | 0.530 |