| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| EFE96180.1 | HemN_3 | HMPREF0758_2114 | HMPREF0758_2111 | YGGT family protein; COG: COG0762; Pfam: PF02325; InterPro: IPR003425. | Putative oxygen-independent coproporphyrinogen III oxidase; Probably acts as a heme chaperone, transferring heme to an unknown acceptor. Binds one molecule of heme per monomer, possibly covalently. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. Belongs to the anaerobic coproporphyrinogen-III oxidase family. | 0.779 |
| EFE96180.1 | YggU | HMPREF0758_2114 | HMPREF0758_2113 | YGGT family protein; COG: COG0762; Pfam: PF02325; InterPro: IPR003425. | TIGR00251 family protein; COG: COG1872; Pfam: PF02594; InterPro: IPR003746; Belongs to the UPF0235 family. | 0.829 |
| EFE96180.1 | fkuA | HMPREF0758_2114 | HMPREF0758_2116 | YGGT family protein; COG: COG0762; Pfam: PF02325; InterPro: IPR003425. | Pyridoxal phosphate enzyme, YggS family; Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis. | 0.893 |
| EFE96180.1 | ftsZ | HMPREF0758_2114 | HMPREF0758_0508 | YGGT family protein; COG: COG0762; Pfam: PF02325; InterPro: IPR003425. | Cell division protein FtsZ; Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity. | 0.602 |
| EFE96180.1 | ispE | HMPREF0758_2114 | HMPREF0758_2117 | YGGT family protein; COG: COG0762; Pfam: PF02325; InterPro: IPR003425. | Twitching motility protein; COG: COG2805; Pfam: PF00437; InterPro: IPR006321. | 0.502 |
| EFE96180.1 | proC | HMPREF0758_2114 | HMPREF0758_2115 | YGGT family protein; COG: COG0762; Pfam: PF02325; InterPro: IPR003425. | Pyrroline-5-carboxylate reductase; Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline. | 0.799 |
| EFE96180.1 | rdgB | HMPREF0758_2114 | HMPREF0758_2112 | YGGT family protein; COG: COG0762; Pfam: PF02325; InterPro: IPR003425. | Non-canonical purine NTP pyrophosphatase, RdgB/HAM1 family; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | 0.786 |
| EFE96180.1 | rseB | HMPREF0758_2114 | HMPREF0758_2449 | YGGT family protein; COG: COG0762; Pfam: PF02325; InterPro: IPR003425. | MucB/RseB family protein; COG: COG3026; Pfam: PF03888; InterPro: IPR005588. | 0.500 |
| EFE96180.1 | skp | HMPREF0758_2114 | HMPREF0758_2340 | YGGT family protein; COG: COG0762; Pfam: PF02325; InterPro: IPR003425. | Outer membrane protein; COG: COG2825; Pfam: PF03938; InterPro: IPR005632; Belongs to the skp family. | 0.593 |
| EFE96180.1 | smtA | HMPREF0758_2114 | HMPREF0758_0372 | YGGT family protein; COG: COG0762; Pfam: PF02325; InterPro: IPR003425. | Methyltransferase domain protein; COG: COG0500; Pfam: PF08241. | 0.566 |
| HemN_3 | EFE96180.1 | HMPREF0758_2111 | HMPREF0758_2114 | Putative oxygen-independent coproporphyrinogen III oxidase; Probably acts as a heme chaperone, transferring heme to an unknown acceptor. Binds one molecule of heme per monomer, possibly covalently. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. Belongs to the anaerobic coproporphyrinogen-III oxidase family. | YGGT family protein; COG: COG0762; Pfam: PF02325; InterPro: IPR003425. | 0.779 |
| HemN_3 | YggU | HMPREF0758_2111 | HMPREF0758_2113 | Putative oxygen-independent coproporphyrinogen III oxidase; Probably acts as a heme chaperone, transferring heme to an unknown acceptor. Binds one molecule of heme per monomer, possibly covalently. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. Belongs to the anaerobic coproporphyrinogen-III oxidase family. | TIGR00251 family protein; COG: COG1872; Pfam: PF02594; InterPro: IPR003746; Belongs to the UPF0235 family. | 0.779 |
| HemN_3 | fkuA | HMPREF0758_2111 | HMPREF0758_2116 | Putative oxygen-independent coproporphyrinogen III oxidase; Probably acts as a heme chaperone, transferring heme to an unknown acceptor. Binds one molecule of heme per monomer, possibly covalently. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. Belongs to the anaerobic coproporphyrinogen-III oxidase family. | Pyridoxal phosphate enzyme, YggS family; Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis. | 0.789 |
| HemN_3 | ispE | HMPREF0758_2111 | HMPREF0758_2117 | Putative oxygen-independent coproporphyrinogen III oxidase; Probably acts as a heme chaperone, transferring heme to an unknown acceptor. Binds one molecule of heme per monomer, possibly covalently. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. Belongs to the anaerobic coproporphyrinogen-III oxidase family. | Twitching motility protein; COG: COG2805; Pfam: PF00437; InterPro: IPR006321. | 0.526 |
| HemN_3 | proC | HMPREF0758_2111 | HMPREF0758_2115 | Putative oxygen-independent coproporphyrinogen III oxidase; Probably acts as a heme chaperone, transferring heme to an unknown acceptor. Binds one molecule of heme per monomer, possibly covalently. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. Belongs to the anaerobic coproporphyrinogen-III oxidase family. | Pyrroline-5-carboxylate reductase; Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline. | 0.772 |
| HemN_3 | rdgB | HMPREF0758_2111 | HMPREF0758_2112 | Putative oxygen-independent coproporphyrinogen III oxidase; Probably acts as a heme chaperone, transferring heme to an unknown acceptor. Binds one molecule of heme per monomer, possibly covalently. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. Belongs to the anaerobic coproporphyrinogen-III oxidase family. | Non-canonical purine NTP pyrophosphatase, RdgB/HAM1 family; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | 0.917 |
| YggU | EFE96180.1 | HMPREF0758_2113 | HMPREF0758_2114 | TIGR00251 family protein; COG: COG1872; Pfam: PF02594; InterPro: IPR003746; Belongs to the UPF0235 family. | YGGT family protein; COG: COG0762; Pfam: PF02325; InterPro: IPR003425. | 0.829 |
| YggU | HemN_3 | HMPREF0758_2113 | HMPREF0758_2111 | TIGR00251 family protein; COG: COG1872; Pfam: PF02594; InterPro: IPR003746; Belongs to the UPF0235 family. | Putative oxygen-independent coproporphyrinogen III oxidase; Probably acts as a heme chaperone, transferring heme to an unknown acceptor. Binds one molecule of heme per monomer, possibly covalently. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. Belongs to the anaerobic coproporphyrinogen-III oxidase family. | 0.779 |
| YggU | fkuA | HMPREF0758_2113 | HMPREF0758_2116 | TIGR00251 family protein; COG: COG1872; Pfam: PF02594; InterPro: IPR003746; Belongs to the UPF0235 family. | Pyridoxal phosphate enzyme, YggS family; Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis. | 0.781 |
| YggU | ispE | HMPREF0758_2113 | HMPREF0758_2117 | TIGR00251 family protein; COG: COG1872; Pfam: PF02594; InterPro: IPR003746; Belongs to the UPF0235 family. | Twitching motility protein; COG: COG2805; Pfam: PF00437; InterPro: IPR006321. | 0.535 |