| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| EFE96180.1 | HemN_3 | HMPREF0758_2114 | HMPREF0758_2111 | YGGT family protein; COG: COG0762; Pfam: PF02325; InterPro: IPR003425. | Putative oxygen-independent coproporphyrinogen III oxidase; Probably acts as a heme chaperone, transferring heme to an unknown acceptor. Binds one molecule of heme per monomer, possibly covalently. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. Belongs to the anaerobic coproporphyrinogen-III oxidase family. | 0.779 |
| EFE96180.1 | YggU | HMPREF0758_2114 | HMPREF0758_2113 | YGGT family protein; COG: COG0762; Pfam: PF02325; InterPro: IPR003425. | TIGR00251 family protein; COG: COG1872; Pfam: PF02594; InterPro: IPR003746; Belongs to the UPF0235 family. | 0.829 |
| EFE96180.1 | fkuA | HMPREF0758_2114 | HMPREF0758_2116 | YGGT family protein; COG: COG0762; Pfam: PF02325; InterPro: IPR003425. | Pyridoxal phosphate enzyme, YggS family; Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis. | 0.893 |
| EFE96180.1 | ispE | HMPREF0758_2114 | HMPREF0758_2117 | YGGT family protein; COG: COG0762; Pfam: PF02325; InterPro: IPR003425. | Twitching motility protein; COG: COG2805; Pfam: PF00437; InterPro: IPR006321. | 0.502 |
| EFE96180.1 | proC | HMPREF0758_2114 | HMPREF0758_2115 | YGGT family protein; COG: COG0762; Pfam: PF02325; InterPro: IPR003425. | Pyrroline-5-carboxylate reductase; Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline. | 0.799 |
| EFE96180.1 | rdgB | HMPREF0758_2114 | HMPREF0758_2112 | YGGT family protein; COG: COG0762; Pfam: PF02325; InterPro: IPR003425. | Non-canonical purine NTP pyrophosphatase, RdgB/HAM1 family; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | 0.786 |
| HemN_3 | EFE96180.1 | HMPREF0758_2111 | HMPREF0758_2114 | Putative oxygen-independent coproporphyrinogen III oxidase; Probably acts as a heme chaperone, transferring heme to an unknown acceptor. Binds one molecule of heme per monomer, possibly covalently. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. Belongs to the anaerobic coproporphyrinogen-III oxidase family. | YGGT family protein; COG: COG0762; Pfam: PF02325; InterPro: IPR003425. | 0.779 |
| HemN_3 | YggU | HMPREF0758_2111 | HMPREF0758_2113 | Putative oxygen-independent coproporphyrinogen III oxidase; Probably acts as a heme chaperone, transferring heme to an unknown acceptor. Binds one molecule of heme per monomer, possibly covalently. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. Belongs to the anaerobic coproporphyrinogen-III oxidase family. | TIGR00251 family protein; COG: COG1872; Pfam: PF02594; InterPro: IPR003746; Belongs to the UPF0235 family. | 0.779 |
| HemN_3 | fkuA | HMPREF0758_2111 | HMPREF0758_2116 | Putative oxygen-independent coproporphyrinogen III oxidase; Probably acts as a heme chaperone, transferring heme to an unknown acceptor. Binds one molecule of heme per monomer, possibly covalently. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. Belongs to the anaerobic coproporphyrinogen-III oxidase family. | Pyridoxal phosphate enzyme, YggS family; Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis. | 0.789 |
| HemN_3 | ispE | HMPREF0758_2111 | HMPREF0758_2117 | Putative oxygen-independent coproporphyrinogen III oxidase; Probably acts as a heme chaperone, transferring heme to an unknown acceptor. Binds one molecule of heme per monomer, possibly covalently. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. Belongs to the anaerobic coproporphyrinogen-III oxidase family. | Twitching motility protein; COG: COG2805; Pfam: PF00437; InterPro: IPR006321. | 0.526 |
| HemN_3 | maf | HMPREF0758_2111 | HMPREF0758_1818 | Putative oxygen-independent coproporphyrinogen III oxidase; Probably acts as a heme chaperone, transferring heme to an unknown acceptor. Binds one molecule of heme per monomer, possibly covalently. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. Belongs to the anaerobic coproporphyrinogen-III oxidase family. | Septum formation protein Maf; Nucleoside triphosphate pyrophosphatase that hydrolyzes dTTP and UTP. May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids. | 0.557 |
| HemN_3 | proC | HMPREF0758_2111 | HMPREF0758_2115 | Putative oxygen-independent coproporphyrinogen III oxidase; Probably acts as a heme chaperone, transferring heme to an unknown acceptor. Binds one molecule of heme per monomer, possibly covalently. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. Belongs to the anaerobic coproporphyrinogen-III oxidase family. | Pyrroline-5-carboxylate reductase; Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline. | 0.772 |
| HemN_3 | rdgB | HMPREF0758_2111 | HMPREF0758_2112 | Putative oxygen-independent coproporphyrinogen III oxidase; Probably acts as a heme chaperone, transferring heme to an unknown acceptor. Binds one molecule of heme per monomer, possibly covalently. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. Belongs to the anaerobic coproporphyrinogen-III oxidase family. | Non-canonical purine NTP pyrophosphatase, RdgB/HAM1 family; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | 0.917 |
| YfiH_1 | fkuA | HMPREF0758_0397 | HMPREF0758_2116 | Conserved hypothetical protein, YfiH family; COG: COG1496; Pfam: PF02578; InterPro: IPR003730; Belongs to the multicopper oxidase YfiH/RL5 family. | Pyridoxal phosphate enzyme, YggS family; Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis. | 0.681 |
| YfiH_2 | fkuA | HMPREF0758_3319 | HMPREF0758_2116 | Conserved hypothetical protein, YfiH family; COG: COG1496; Pfam: PF02578; InterPro: IPR003730. | Pyridoxal phosphate enzyme, YggS family; Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis. | 0.632 |
| YggU | EFE96180.1 | HMPREF0758_2113 | HMPREF0758_2114 | TIGR00251 family protein; COG: COG1872; Pfam: PF02594; InterPro: IPR003746; Belongs to the UPF0235 family. | YGGT family protein; COG: COG0762; Pfam: PF02325; InterPro: IPR003425. | 0.829 |
| YggU | HemN_3 | HMPREF0758_2113 | HMPREF0758_2111 | TIGR00251 family protein; COG: COG1872; Pfam: PF02594; InterPro: IPR003746; Belongs to the UPF0235 family. | Putative oxygen-independent coproporphyrinogen III oxidase; Probably acts as a heme chaperone, transferring heme to an unknown acceptor. Binds one molecule of heme per monomer, possibly covalently. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. Belongs to the anaerobic coproporphyrinogen-III oxidase family. | 0.779 |
| YggU | fkuA | HMPREF0758_2113 | HMPREF0758_2116 | TIGR00251 family protein; COG: COG1872; Pfam: PF02594; InterPro: IPR003746; Belongs to the UPF0235 family. | Pyridoxal phosphate enzyme, YggS family; Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis. | 0.781 |
| YggU | ispE | HMPREF0758_2113 | HMPREF0758_2117 | TIGR00251 family protein; COG: COG1872; Pfam: PF02594; InterPro: IPR003746; Belongs to the UPF0235 family. | Twitching motility protein; COG: COG2805; Pfam: PF00437; InterPro: IPR006321. | 0.535 |
| YggU | proC | HMPREF0758_2113 | HMPREF0758_2115 | TIGR00251 family protein; COG: COG1872; Pfam: PF02594; InterPro: IPR003746; Belongs to the UPF0235 family. | Pyrroline-5-carboxylate reductase; Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline. | 0.761 |