| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| EFE96700.1 | pdhR | HMPREF0758_1675 | HMPREF0758_2136 | Hypothetical protein; COG: COG3068; Pfam: PF04222; InterPro: IPR007338. | Transcriptional regulator PdhR; COG: COG2186; Pfam: PF00392,PF07729; InterPro: IPR011711. | 0.449 |
| EFE97364.1 | pdhR | HMPREF0758_0977 | HMPREF0758_2136 | Hypothetical protein; COG: COG3529; InterPro: IPR012658. | Transcriptional regulator PdhR; COG: COG2186; Pfam: PF00392,PF07729; InterPro: IPR011711. | 0.419 |
| NadR_1 | YdfH_2 | HMPREF0758_0608 | HMPREF0758_2219 | Nicotinamide-nucleotide adenylyltransferase; COG: COG3172; Pfam: PF01381; InterPro: IPR006417. | FCD domain protein; COG: COG1802; Pfam: PF00392,PF07729; InterPro: IPR011711. | 0.465 |
| NadR_1 | YdfH_4 | HMPREF0758_0608 | HMPREF0758_3752 | Nicotinamide-nucleotide adenylyltransferase; COG: COG3172; Pfam: PF01381; InterPro: IPR006417. | Transcriptional regulator, GntR family; COG: COG1802; Pfam: PF00392,PF07729; InterPro: IPR011991. | 0.465 |
| NadR_1 | pdhR | HMPREF0758_0608 | HMPREF0758_2136 | Nicotinamide-nucleotide adenylyltransferase; COG: COG3172; Pfam: PF01381; InterPro: IPR006417. | Transcriptional regulator PdhR; COG: COG2186; Pfam: PF00392,PF07729; InterPro: IPR011711. | 0.518 |
| YdfH_2 | NadR_1 | HMPREF0758_2219 | HMPREF0758_0608 | FCD domain protein; COG: COG1802; Pfam: PF00392,PF07729; InterPro: IPR011711. | Nicotinamide-nucleotide adenylyltransferase; COG: COG3172; Pfam: PF01381; InterPro: IPR006417. | 0.465 |
| YdfH_2 | pdhR | HMPREF0758_2219 | HMPREF0758_2136 | FCD domain protein; COG: COG1802; Pfam: PF00392,PF07729; InterPro: IPR011711. | Transcriptional regulator PdhR; COG: COG2186; Pfam: PF00392,PF07729; InterPro: IPR011711. | 0.578 |
| YdfH_4 | NadR_1 | HMPREF0758_3752 | HMPREF0758_0608 | Transcriptional regulator, GntR family; COG: COG1802; Pfam: PF00392,PF07729; InterPro: IPR011991. | Nicotinamide-nucleotide adenylyltransferase; COG: COG3172; Pfam: PF01381; InterPro: IPR006417. | 0.465 |
| YdfH_4 | pdhR | HMPREF0758_3752 | HMPREF0758_2136 | Transcriptional regulator, GntR family; COG: COG1802; Pfam: PF00392,PF07729; InterPro: IPR011991. | Transcriptional regulator PdhR; COG: COG2186; Pfam: PF00392,PF07729; InterPro: IPR011711. | 0.560 |
| aceE | aceF | HMPREF0758_2137 | HMPREF0758_2138 | Pyruvate dehydrogenase (acetyl-transferring), homodimeric type; Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). | Dihydrolipoamide acetyltransferase; COG: COG0508; Pfam: PF00364; InterPro: IPR000089. | 0.990 |
| aceE | aceF-2 | HMPREF0758_2137 | HMPREF0758_2139 | Pyruvate dehydrogenase (acetyl-transferring), homodimeric type; Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). | Dihydrolipoyllysine-residue acetyltransferase; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). | 0.997 |
| aceE | lldD | HMPREF0758_2137 | HMPREF0758_2265 | Pyruvate dehydrogenase (acetyl-transferring), homodimeric type; Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). | Dehydrogenase, FMN-dependent; Catalyzes the conversion of L-lactate to pyruvate. Is coupled to the respiratory chain; Belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family. | 0.917 |
| aceE | pdhR | HMPREF0758_2137 | HMPREF0758_2136 | Pyruvate dehydrogenase (acetyl-transferring), homodimeric type; Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). | Transcriptional regulator PdhR; COG: COG2186; Pfam: PF00392,PF07729; InterPro: IPR011711. | 0.556 |
| aceF | aceE | HMPREF0758_2138 | HMPREF0758_2137 | Dihydrolipoamide acetyltransferase; COG: COG0508; Pfam: PF00364; InterPro: IPR000089. | Pyruvate dehydrogenase (acetyl-transferring), homodimeric type; Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). | 0.990 |
| aceF | aceF-2 | HMPREF0758_2138 | HMPREF0758_2139 | Dihydrolipoamide acetyltransferase; COG: COG0508; Pfam: PF00364; InterPro: IPR000089. | Dihydrolipoyllysine-residue acetyltransferase; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). | 0.864 |
| aceF | pdhR | HMPREF0758_2138 | HMPREF0758_2136 | Dihydrolipoamide acetyltransferase; COG: COG0508; Pfam: PF00364; InterPro: IPR000089. | Transcriptional regulator PdhR; COG: COG2186; Pfam: PF00392,PF07729; InterPro: IPR011711. | 0.479 |
| aceF-2 | aceE | HMPREF0758_2139 | HMPREF0758_2137 | Dihydrolipoyllysine-residue acetyltransferase; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). | Pyruvate dehydrogenase (acetyl-transferring), homodimeric type; Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). | 0.997 |
| aceF-2 | aceF | HMPREF0758_2139 | HMPREF0758_2138 | Dihydrolipoyllysine-residue acetyltransferase; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). | Dihydrolipoamide acetyltransferase; COG: COG0508; Pfam: PF00364; InterPro: IPR000089. | 0.864 |
| aceF-2 | pdhR | HMPREF0758_2139 | HMPREF0758_2136 | Dihydrolipoyllysine-residue acetyltransferase; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). | Transcriptional regulator PdhR; COG: COG2186; Pfam: PF00392,PF07729; InterPro: IPR011711. | 0.479 |
| lctP | lldD | HMPREF0758_2266 | HMPREF0758_2265 | Transporter, lactate permease (LctP) family; Transports L-lactate across the membrane. Can also transport D-lactate and glycolate; Belongs to the lactate permease family. | Dehydrogenase, FMN-dependent; Catalyzes the conversion of L-lactate to pyruvate. Is coupled to the respiratory chain; Belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family. | 0.958 |