| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| EFE94277.1 | ampE | HMPREF0758_4372 | HMPREF0758_0494 | Hypothetical protein. | Regulatory protein AmpE; COG: COG3725. | 0.760 |
| EFE94277.1 | csiE | HMPREF0758_4372 | HMPREF0758_2480 | Hypothetical protein. | PRD domain protein; COG: COG3711; Pfam: PF00874; InterPro: IPR011608. | 0.630 |
| EFE94277.1 | ligT | HMPREF0758_4372 | HMPREF0758_2166 | Hypothetical protein. | 2'-5' RNA ligase; Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester; Belongs to the 2H phosphoesterase superfamily. ThpR family. | 0.418 |
| ampE | EFE94277.1 | HMPREF0758_0494 | HMPREF0758_4372 | Regulatory protein AmpE; COG: COG3725. | Hypothetical protein. | 0.760 |
| ampE | csiE | HMPREF0758_0494 | HMPREF0758_2480 | Regulatory protein AmpE; COG: COG3725. | PRD domain protein; COG: COG3711; Pfam: PF00874; InterPro: IPR011608. | 0.450 |
| ampE | ligT | HMPREF0758_0494 | HMPREF0758_2166 | Regulatory protein AmpE; COG: COG3725. | 2'-5' RNA ligase; Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester; Belongs to the 2H phosphoesterase superfamily. ThpR family. | 0.452 |
| bioD | ligT | HMPREF0758_3827 | HMPREF0758_2166 | Dethiobiotin synthase; Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8- diaminopelargonic acid (DAPA) to form an ureido ring. Belongs to the dethiobiotin synthetase family. | 2'-5' RNA ligase; Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester; Belongs to the 2H phosphoesterase superfamily. ThpR family. | 0.483 |
| csiE | EFE94277.1 | HMPREF0758_2480 | HMPREF0758_4372 | PRD domain protein; COG: COG3711; Pfam: PF00874; InterPro: IPR011608. | Hypothetical protein. | 0.630 |
| csiE | ampE | HMPREF0758_2480 | HMPREF0758_0494 | PRD domain protein; COG: COG3711; Pfam: PF00874; InterPro: IPR011608. | Regulatory protein AmpE; COG: COG3725. | 0.450 |
| csiE | ligT | HMPREF0758_2480 | HMPREF0758_2166 | PRD domain protein; COG: COG3711; Pfam: PF00874; InterPro: IPR011608. | 2'-5' RNA ligase; Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester; Belongs to the 2H phosphoesterase superfamily. ThpR family. | 0.492 |
| dksA | ligT | HMPREF0758_2164 | HMPREF0758_2166 | RNA polymerase-binding protein DksA; Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters. Also required for regulation of fis expression. | 2'-5' RNA ligase; Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester; Belongs to the 2H phosphoesterase superfamily. ThpR family. | 0.466 |
| dksA | sfsA | HMPREF0758_2164 | HMPREF0758_2165 | RNA polymerase-binding protein DksA; Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters. Also required for regulation of fis expression. | Sugar fermentation stimulation protein; COG: COG1489; Pfam: PF03749; InterPro: IPR005224; Belongs to the SfsA family. | 0.583 |
| fes | ligT | HMPREF0758_2674 | HMPREF0758_2166 | Putative esterase; COG: COG2382; Pfam: PF00756; InterPro: IPR000801. | 2'-5' RNA ligase; Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester; Belongs to the 2H phosphoesterase superfamily. ThpR family. | 0.437 |
| hrpB | ligT | HMPREF0758_2167 | HMPREF0758_2166 | ATP-dependent helicase HrpB; COG: COG1643; Pfam: PF00270,PF00271,PF04408,PF08482; InterPro: IPR010225. | 2'-5' RNA ligase; Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester; Belongs to the 2H phosphoesterase superfamily. ThpR family. | 0.585 |
| hrpB | sfsA | HMPREF0758_2167 | HMPREF0758_2165 | ATP-dependent helicase HrpB; COG: COG1643; Pfam: PF00270,PF00271,PF04408,PF08482; InterPro: IPR010225. | Sugar fermentation stimulation protein; COG: COG1489; Pfam: PF03749; InterPro: IPR005224; Belongs to the SfsA family. | 0.581 |
| ligT | EFE94277.1 | HMPREF0758_2166 | HMPREF0758_4372 | 2'-5' RNA ligase; Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester; Belongs to the 2H phosphoesterase superfamily. ThpR family. | Hypothetical protein. | 0.418 |
| ligT | ampE | HMPREF0758_2166 | HMPREF0758_0494 | 2'-5' RNA ligase; Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester; Belongs to the 2H phosphoesterase superfamily. ThpR family. | Regulatory protein AmpE; COG: COG3725. | 0.452 |
| ligT | bioD | HMPREF0758_2166 | HMPREF0758_3827 | 2'-5' RNA ligase; Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester; Belongs to the 2H phosphoesterase superfamily. ThpR family. | Dethiobiotin synthase; Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8- diaminopelargonic acid (DAPA) to form an ureido ring. Belongs to the dethiobiotin synthetase family. | 0.483 |
| ligT | csiE | HMPREF0758_2166 | HMPREF0758_2480 | 2'-5' RNA ligase; Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester; Belongs to the 2H phosphoesterase superfamily. ThpR family. | PRD domain protein; COG: COG3711; Pfam: PF00874; InterPro: IPR011608. | 0.492 |
| ligT | dksA | HMPREF0758_2166 | HMPREF0758_2164 | 2'-5' RNA ligase; Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester; Belongs to the 2H phosphoesterase superfamily. ThpR family. | RNA polymerase-binding protein DksA; Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters. Also required for regulation of fis expression. | 0.466 |