STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ilvB3Thiamine pyrophosphate enzyme, C-terminal TPP binding domain protein; Pfam: PF02776,PF00205,PF02775; InterPro: IPR012001; Belongs to the TPP enzyme family. (559 aa)    
Predicted Functional Partners:
ilvN
Acetolactate synthase, small subunit; COG: COG0440; Pfam: PF01842; InterPro: IPR004789.
 
 0.985
ilvN-2
Acetolactate synthase 1 regulatory subunit; COG: COG0440.
 
 0.972
ilvC
Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.
 
 
 0.968
leuB
3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate.
 
 0.958
nifJ
Pyruvate synthase; COG: COG0674; Pfam: PF01855,PF01558,PF00037,PF02775; InterPro: IPR011895.
  
 
 0.951
leuB2
Tartrate dehydrogenase; COG: COG0473; Pfam: PF00180; InterPro: IPR001804.
 
 0.943
budA
Alpha-acetolactate decarboxylase; COG: COG3527; Pfam: PF03306; InterPro: IPR005128; Belongs to the alpha-acetolactate decarboxylase family.
  
 
 0.942
IlvB_3
Thiamine pyrophosphate enzyme, C-terminal TPP binding domain protein; Pfam: PF02776,PF00205,PF02775; InterPro: IPR012001; Belongs to the TPP enzyme family.
  
  
 
0.929
ilvB
Acetolactate synthase, large subunit, biosynthetic type; COG: COG0028; Pfam: PF02776,PF00205,PF02775; InterPro: IPR012846.
  
  
 
0.927
ilvB-3
Acetolactate synthase, large subunit, biosynthetic type; COG: COG0028; Pfam: PF02776,PF00205,PF02775; InterPro: IPR012846.
  
  
 
0.927
Your Current Organism:
Serratia odorifera
NCBI taxonomy Id: 667129
Other names: S. odorifera DSM 4582, Serratia odorifera DSM 4582, Serratia odorifera str. DSM 4582, Serratia odorifera strain DSM 4582
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.