| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| YggG_1 | grpE | HMPREF0758_2194 | HMPREF0758_2441 | Peptidase, M48 family; COG: COG0501; Pfam: PF01435; InterPro: IPR001915. | Co-chaperone GrpE; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-depend [...] | 0.491 |
| YggG_1 | hflB | HMPREF0758_2194 | HMPREF0758_0810 | Peptidase, M48 family; COG: COG0501; Pfam: PF01435; InterPro: IPR001915. | Cell division protease FtsH; Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins; Belongs to the AAA ATPase family. In the central section; belongs to the AAA ATPase family. | 0.464 |
| YggG_1 | kefB | HMPREF0758_2194 | HMPREF0758_0978 | Peptidase, M48 family; COG: COG0501; Pfam: PF01435; InterPro: IPR001915. | Transporter, CPA2 family; Pore-forming subunit of a potassium efflux system that confers protection against electrophiles. Catalyzes K(+)/H(+) antiport. | 0.413 |
| YggG_1 | kefC | HMPREF0758_2194 | HMPREF0758_0561 | Peptidase, M48 family; COG: COG0501; Pfam: PF01435; InterPro: IPR001915. | Transporter, CPA2 family; Pore-forming subunit of a potassium efflux system that confers protection against electrophiles. Catalyzes K(+)/H(+) antiport. | 0.413 |
| YggG_1 | rhsD | HMPREF0758_2194 | HMPREF0758_0692 | Peptidase, M48 family; COG: COG0501; Pfam: PF01435; InterPro: IPR001915. | RHS repeat-associated core domain protein; COG: COG3209. | 0.427 |
| grpE | YggG_1 | HMPREF0758_2441 | HMPREF0758_2194 | Co-chaperone GrpE; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-depend [...] | Peptidase, M48 family; COG: COG0501; Pfam: PF01435; InterPro: IPR001915. | 0.491 |
| grpE | hflB | HMPREF0758_2441 | HMPREF0758_0810 | Co-chaperone GrpE; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-depend [...] | Cell division protease FtsH; Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins; Belongs to the AAA ATPase family. In the central section; belongs to the AAA ATPase family. | 0.691 |
| hflB | YggG_1 | HMPREF0758_0810 | HMPREF0758_2194 | Cell division protease FtsH; Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins; Belongs to the AAA ATPase family. In the central section; belongs to the AAA ATPase family. | Peptidase, M48 family; COG: COG0501; Pfam: PF01435; InterPro: IPR001915. | 0.464 |
| hflB | grpE | HMPREF0758_0810 | HMPREF0758_2441 | Cell division protease FtsH; Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins; Belongs to the AAA ATPase family. In the central section; belongs to the AAA ATPase family. | Co-chaperone GrpE; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-depend [...] | 0.691 |
| hflB | kefB | HMPREF0758_0810 | HMPREF0758_0978 | Cell division protease FtsH; Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins; Belongs to the AAA ATPase family. In the central section; belongs to the AAA ATPase family. | Transporter, CPA2 family; Pore-forming subunit of a potassium efflux system that confers protection against electrophiles. Catalyzes K(+)/H(+) antiport. | 0.428 |
| hflB | kefC | HMPREF0758_0810 | HMPREF0758_0561 | Cell division protease FtsH; Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins; Belongs to the AAA ATPase family. In the central section; belongs to the AAA ATPase family. | Transporter, CPA2 family; Pore-forming subunit of a potassium efflux system that confers protection against electrophiles. Catalyzes K(+)/H(+) antiport. | 0.428 |
| kefB | YggG_1 | HMPREF0758_0978 | HMPREF0758_2194 | Transporter, CPA2 family; Pore-forming subunit of a potassium efflux system that confers protection against electrophiles. Catalyzes K(+)/H(+) antiport. | Peptidase, M48 family; COG: COG0501; Pfam: PF01435; InterPro: IPR001915. | 0.413 |
| kefB | hflB | HMPREF0758_0978 | HMPREF0758_0810 | Transporter, CPA2 family; Pore-forming subunit of a potassium efflux system that confers protection against electrophiles. Catalyzes K(+)/H(+) antiport. | Cell division protease FtsH; Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins; Belongs to the AAA ATPase family. In the central section; belongs to the AAA ATPase family. | 0.428 |
| kefB | kefC | HMPREF0758_0978 | HMPREF0758_0561 | Transporter, CPA2 family; Pore-forming subunit of a potassium efflux system that confers protection against electrophiles. Catalyzes K(+)/H(+) antiport. | Transporter, CPA2 family; Pore-forming subunit of a potassium efflux system that confers protection against electrophiles. Catalyzes K(+)/H(+) antiport. | 0.551 |
| kefC | YggG_1 | HMPREF0758_0561 | HMPREF0758_2194 | Transporter, CPA2 family; Pore-forming subunit of a potassium efflux system that confers protection against electrophiles. Catalyzes K(+)/H(+) antiport. | Peptidase, M48 family; COG: COG0501; Pfam: PF01435; InterPro: IPR001915. | 0.413 |
| kefC | hflB | HMPREF0758_0561 | HMPREF0758_0810 | Transporter, CPA2 family; Pore-forming subunit of a potassium efflux system that confers protection against electrophiles. Catalyzes K(+)/H(+) antiport. | Cell division protease FtsH; Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins; Belongs to the AAA ATPase family. In the central section; belongs to the AAA ATPase family. | 0.428 |
| kefC | kefB | HMPREF0758_0561 | HMPREF0758_0978 | Transporter, CPA2 family; Pore-forming subunit of a potassium efflux system that confers protection against electrophiles. Catalyzes K(+)/H(+) antiport. | Transporter, CPA2 family; Pore-forming subunit of a potassium efflux system that confers protection against electrophiles. Catalyzes K(+)/H(+) antiport. | 0.551 |
| rhsD | YggG_1 | HMPREF0758_0692 | HMPREF0758_2194 | RHS repeat-associated core domain protein; COG: COG3209. | Peptidase, M48 family; COG: COG0501; Pfam: PF01435; InterPro: IPR001915. | 0.427 |