| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| YrbG | mscS2 | HMPREF0758_1857 | HMPREF0758_2201 | K+-dependent Na+/Ca+ exchanger family protein; COG: COG0530; Pfam: PF01699; InterPro: IPR004481. | Transporter, small conductance mechanosensitive ion channel MscS family protein; COG: COG0668; Pfam: PF05552,PF00924; InterPro: IPR006685. | 0.483 |
| argO | mscS2 | HMPREF0758_2202 | HMPREF0758_2201 | Putative arginine exporter protein ArgO; COG: COG1279; Pfam: PF01810; InterPro: IPR001123. | Transporter, small conductance mechanosensitive ion channel MscS family protein; COG: COG0668; Pfam: PF05552,PF00924; InterPro: IPR006685. | 0.481 |
| fbaA | gcvP | HMPREF0758_2200 | HMPREF0758_2216 | Fructose-bisphosphate aldolase, class II; Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis; Belongs to the class II fructose-bisphosphate aldolase family. | Glycine dehydrogenase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. | 0.426 |
| fbaA | mscS2 | HMPREF0758_2200 | HMPREF0758_2201 | Fructose-bisphosphate aldolase, class II; Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis; Belongs to the class II fructose-bisphosphate aldolase family. | Transporter, small conductance mechanosensitive ion channel MscS family protein; COG: COG0668; Pfam: PF05552,PF00924; InterPro: IPR006685. | 0.453 |
| gcvP | fbaA | HMPREF0758_2216 | HMPREF0758_2200 | Glycine dehydrogenase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. | Fructose-bisphosphate aldolase, class II; Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis; Belongs to the class II fructose-bisphosphate aldolase family. | 0.426 |
| gcvP | mscS2 | HMPREF0758_2216 | HMPREF0758_2201 | Glycine dehydrogenase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. | Transporter, small conductance mechanosensitive ion channel MscS family protein; COG: COG0668; Pfam: PF05552,PF00924; InterPro: IPR006685. | 0.518 |
| kefB | kefC | HMPREF0758_0978 | HMPREF0758_0561 | Transporter, CPA2 family; Pore-forming subunit of a potassium efflux system that confers protection against electrophiles. Catalyzes K(+)/H(+) antiport. | Transporter, CPA2 family; Pore-forming subunit of a potassium efflux system that confers protection against electrophiles. Catalyzes K(+)/H(+) antiport. | 0.551 |
| kefB | mscS2 | HMPREF0758_0978 | HMPREF0758_2201 | Transporter, CPA2 family; Pore-forming subunit of a potassium efflux system that confers protection against electrophiles. Catalyzes K(+)/H(+) antiport. | Transporter, small conductance mechanosensitive ion channel MscS family protein; COG: COG0668; Pfam: PF05552,PF00924; InterPro: IPR006685. | 0.414 |
| kefB | rimK | HMPREF0758_0978 | HMPREF0758_4492 | Transporter, CPA2 family; Pore-forming subunit of a potassium efflux system that confers protection against electrophiles. Catalyzes K(+)/H(+) antiport. | alpha-L-glutamate ligase, RimK family; COG: COG0189; Pfam: PF08443; InterPro: IPR004666; Belongs to the RimK family. | 0.429 |
| kefC | kefB | HMPREF0758_0561 | HMPREF0758_0978 | Transporter, CPA2 family; Pore-forming subunit of a potassium efflux system that confers protection against electrophiles. Catalyzes K(+)/H(+) antiport. | Transporter, CPA2 family; Pore-forming subunit of a potassium efflux system that confers protection against electrophiles. Catalyzes K(+)/H(+) antiport. | 0.551 |
| kefC | mscS2 | HMPREF0758_0561 | HMPREF0758_2201 | Transporter, CPA2 family; Pore-forming subunit of a potassium efflux system that confers protection against electrophiles. Catalyzes K(+)/H(+) antiport. | Transporter, small conductance mechanosensitive ion channel MscS family protein; COG: COG0668; Pfam: PF05552,PF00924; InterPro: IPR006685. | 0.414 |
| kefC | rimK | HMPREF0758_0561 | HMPREF0758_4492 | Transporter, CPA2 family; Pore-forming subunit of a potassium efflux system that confers protection against electrophiles. Catalyzes K(+)/H(+) antiport. | alpha-L-glutamate ligase, RimK family; COG: COG0189; Pfam: PF08443; InterPro: IPR004666; Belongs to the RimK family. | 0.429 |
| mscS2 | YrbG | HMPREF0758_2201 | HMPREF0758_1857 | Transporter, small conductance mechanosensitive ion channel MscS family protein; COG: COG0668; Pfam: PF05552,PF00924; InterPro: IPR006685. | K+-dependent Na+/Ca+ exchanger family protein; COG: COG0530; Pfam: PF01699; InterPro: IPR004481. | 0.483 |
| mscS2 | argO | HMPREF0758_2201 | HMPREF0758_2202 | Transporter, small conductance mechanosensitive ion channel MscS family protein; COG: COG0668; Pfam: PF05552,PF00924; InterPro: IPR006685. | Putative arginine exporter protein ArgO; COG: COG1279; Pfam: PF01810; InterPro: IPR001123. | 0.481 |
| mscS2 | fbaA | HMPREF0758_2201 | HMPREF0758_2200 | Transporter, small conductance mechanosensitive ion channel MscS family protein; COG: COG0668; Pfam: PF05552,PF00924; InterPro: IPR006685. | Fructose-bisphosphate aldolase, class II; Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis; Belongs to the class II fructose-bisphosphate aldolase family. | 0.453 |
| mscS2 | gcvP | HMPREF0758_2201 | HMPREF0758_2216 | Transporter, small conductance mechanosensitive ion channel MscS family protein; COG: COG0668; Pfam: PF05552,PF00924; InterPro: IPR006685. | Glycine dehydrogenase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. | 0.518 |
| mscS2 | kefB | HMPREF0758_2201 | HMPREF0758_0978 | Transporter, small conductance mechanosensitive ion channel MscS family protein; COG: COG0668; Pfam: PF05552,PF00924; InterPro: IPR006685. | Transporter, CPA2 family; Pore-forming subunit of a potassium efflux system that confers protection against electrophiles. Catalyzes K(+)/H(+) antiport. | 0.414 |
| mscS2 | kefC | HMPREF0758_2201 | HMPREF0758_0561 | Transporter, small conductance mechanosensitive ion channel MscS family protein; COG: COG0668; Pfam: PF05552,PF00924; InterPro: IPR006685. | Transporter, CPA2 family; Pore-forming subunit of a potassium efflux system that confers protection against electrophiles. Catalyzes K(+)/H(+) antiport. | 0.414 |
| mscS2 | rimK | HMPREF0758_2201 | HMPREF0758_4492 | Transporter, small conductance mechanosensitive ion channel MscS family protein; COG: COG0668; Pfam: PF05552,PF00924; InterPro: IPR006685. | alpha-L-glutamate ligase, RimK family; COG: COG0189; Pfam: PF08443; InterPro: IPR004666; Belongs to the RimK family. | 0.577 |
| rimK | kefB | HMPREF0758_4492 | HMPREF0758_0978 | alpha-L-glutamate ligase, RimK family; COG: COG0189; Pfam: PF08443; InterPro: IPR004666; Belongs to the RimK family. | Transporter, CPA2 family; Pore-forming subunit of a potassium efflux system that confers protection against electrophiles. Catalyzes K(+)/H(+) antiport. | 0.429 |