| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| EFE96124.1 | pepP | HMPREF0758_2210 | HMPREF0758_2211 | yecA family protein; COG: COG3079; Pfam: PF03695; InterPro: IPR005356; Belongs to the UPF0149 family. | Aminopeptidase P domain protein; COG: COG0006; Pfam: PF05195,PF00557; InterPro: IPR000994. | 0.639 |
| EFE96124.1 | ubiF | HMPREF0758_2210 | HMPREF0758_2213 | yecA family protein; COG: COG3079; Pfam: PF03695; InterPro: IPR005356; Belongs to the UPF0149 family. | Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; COG: COG0654; Pfam: PF01266; InterPro: IPR010971. | 0.565 |
| EFE96124.1 | ubiH | HMPREF0758_2210 | HMPREF0758_2212 | yecA family protein; COG: COG3079; Pfam: PF03695; InterPro: IPR005356; Belongs to the UPF0149 family. | 2-polyprenyl-6-methoxyphenol 4-hydroxylase; COG: COG0654; Pfam: PF01266; InterPro: IPR010971. | 0.728 |
| EFE96124.1 | zapA | HMPREF0758_2210 | HMPREF0758_2209 | yecA family protein; COG: COG3079; Pfam: PF03695; InterPro: IPR005356; Belongs to the UPF0149 family. | Cell division protein ZapA; Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division. | 0.571 |
| grxD | ubiA | HMPREF0758_3922 | HMPREF0758_1705 | Monothiol glutaredoxin, Grx4 family; COG: COG0278; Pfam: PF00462; InterPro: IPR012335; Belongs to the glutaredoxin family. Monothiol subfamily. | 4-hydroxybenzoate polyprenyl transferase; Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3-octaprenyl-4-hydroxybenzoate. | 0.506 |
| grxD | ubiF | HMPREF0758_3922 | HMPREF0758_2213 | Monothiol glutaredoxin, Grx4 family; COG: COG0278; Pfam: PF00462; InterPro: IPR012335; Belongs to the glutaredoxin family. Monothiol subfamily. | Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; COG: COG0654; Pfam: PF01266; InterPro: IPR010971. | 0.619 |
| grxD | ubiG | HMPREF0758_3922 | HMPREF0758_2830 | Monothiol glutaredoxin, Grx4 family; COG: COG0278; Pfam: PF00462; InterPro: IPR012335; Belongs to the glutaredoxin family. Monothiol subfamily. | 3-demethylubiquinone-9 3-O-methyltransferase; O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway; Belongs to the methyltransferase superfamily. UbiG/COQ3 family. | 0.530 |
| grxD | ubiH | HMPREF0758_3922 | HMPREF0758_2212 | Monothiol glutaredoxin, Grx4 family; COG: COG0278; Pfam: PF00462; InterPro: IPR012335; Belongs to the glutaredoxin family. Monothiol subfamily. | 2-polyprenyl-6-methoxyphenol 4-hydroxylase; COG: COG0654; Pfam: PF01266; InterPro: IPR010971. | 0.703 |
| hemF | ubiA | HMPREF0758_2642 | HMPREF0758_1705 | Coproporphyrinogen III oxidase, aerobic; Involved in the heme biosynthesis. Catalyzes the aerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen-III to yield the vinyl groups in protoporphyrinogen- IX. | 4-hydroxybenzoate polyprenyl transferase; Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3-octaprenyl-4-hydroxybenzoate. | 0.481 |
| hemF | ubiF | HMPREF0758_2642 | HMPREF0758_2213 | Coproporphyrinogen III oxidase, aerobic; Involved in the heme biosynthesis. Catalyzes the aerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen-III to yield the vinyl groups in protoporphyrinogen- IX. | Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; COG: COG0654; Pfam: PF01266; InterPro: IPR010971. | 0.541 |
| hemF | ubiH | HMPREF0758_2642 | HMPREF0758_2212 | Coproporphyrinogen III oxidase, aerobic; Involved in the heme biosynthesis. Catalyzes the aerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen-III to yield the vinyl groups in protoporphyrinogen- IX. | 2-polyprenyl-6-methoxyphenol 4-hydroxylase; COG: COG0654; Pfam: PF01266; InterPro: IPR010971. | 0.571 |
| pepP | EFE96124.1 | HMPREF0758_2211 | HMPREF0758_2210 | Aminopeptidase P domain protein; COG: COG0006; Pfam: PF05195,PF00557; InterPro: IPR000994. | yecA family protein; COG: COG3079; Pfam: PF03695; InterPro: IPR005356; Belongs to the UPF0149 family. | 0.639 |
| pepP | ubiF | HMPREF0758_2211 | HMPREF0758_2213 | Aminopeptidase P domain protein; COG: COG0006; Pfam: PF05195,PF00557; InterPro: IPR000994. | Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; COG: COG0654; Pfam: PF01266; InterPro: IPR010971. | 0.729 |
| pepP | ubiH | HMPREF0758_2211 | HMPREF0758_2212 | Aminopeptidase P domain protein; COG: COG0006; Pfam: PF05195,PF00557; InterPro: IPR000994. | 2-polyprenyl-6-methoxyphenol 4-hydroxylase; COG: COG0654; Pfam: PF01266; InterPro: IPR010971. | 0.815 |
| pepP | zapA | HMPREF0758_2211 | HMPREF0758_2209 | Aminopeptidase P domain protein; COG: COG0006; Pfam: PF05195,PF00557; InterPro: IPR000994. | Cell division protein ZapA; Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division. | 0.526 |
| ubiA | grxD | HMPREF0758_1705 | HMPREF0758_3922 | 4-hydroxybenzoate polyprenyl transferase; Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3-octaprenyl-4-hydroxybenzoate. | Monothiol glutaredoxin, Grx4 family; COG: COG0278; Pfam: PF00462; InterPro: IPR012335; Belongs to the glutaredoxin family. Monothiol subfamily. | 0.506 |
| ubiA | hemF | HMPREF0758_1705 | HMPREF0758_2642 | 4-hydroxybenzoate polyprenyl transferase; Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3-octaprenyl-4-hydroxybenzoate. | Coproporphyrinogen III oxidase, aerobic; Involved in the heme biosynthesis. Catalyzes the aerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen-III to yield the vinyl groups in protoporphyrinogen- IX. | 0.481 |
| ubiA | ubiE | HMPREF0758_1705 | HMPREF0758_1634 | 4-hydroxybenzoate polyprenyl transferase; Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3-octaprenyl-4-hydroxybenzoate. | Ubiquinone/menaquinone biosynthesis methyltransferase; Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3- methyl-6-methoxy-1,4-benzoquinol (DMQH2). | 0.585 |
| ubiA | ubiF | HMPREF0758_1705 | HMPREF0758_2213 | 4-hydroxybenzoate polyprenyl transferase; Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3-octaprenyl-4-hydroxybenzoate. | Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; COG: COG0654; Pfam: PF01266; InterPro: IPR010971. | 0.773 |
| ubiA | ubiG | HMPREF0758_1705 | HMPREF0758_2830 | 4-hydroxybenzoate polyprenyl transferase; Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3-octaprenyl-4-hydroxybenzoate. | 3-demethylubiquinone-9 3-O-methyltransferase; O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway; Belongs to the methyltransferase superfamily. UbiG/COQ3 family. | 0.812 |