| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| YggX | erpA | HMPREF0758_2105 | HMPREF0758_0491 | Bacterial Fe(2+) trafficking; Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and/or repair of Fe-S clusters in biosynthetic enzymes; Belongs to the Fe(2+)-trafficking protein family. | Iron-sulfur cluster assembly accessory protein; Required for insertion of 4Fe-4S clusters for at least IspG. | 0.425 |
| YggX | ftsQ | HMPREF0758_2105 | HMPREF0758_0510 | Bacterial Fe(2+) trafficking; Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and/or repair of Fe-S clusters in biosynthetic enzymes; Belongs to the Fe(2+)-trafficking protein family. | Cell division protein FtsQ; Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly. | 0.583 |
| YggX | secE | HMPREF0758_2105 | HMPREF0758_1656 | Bacterial Fe(2+) trafficking; Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and/or repair of Fe-S clusters in biosynthetic enzymes; Belongs to the Fe(2+)-trafficking protein family. | Preprotein translocase, SecE subunit; Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation; Belongs to the SecE/SEC61-gamma family. | 0.475 |
| YggX | ygfZ | HMPREF0758_2105 | HMPREF0758_2227 | Bacterial Fe(2+) trafficking; Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and/or repair of Fe-S clusters in biosynthetic enzymes; Belongs to the Fe(2+)-trafficking protein family. | Folate-binding protein YgfZ; Folate-binding protein involved in regulating the level of ATP-DnaA and in the modification of some tRNAs. It is probably a key factor in regulatory networks that act via tRNA modification, such as initiation of chromosomal replication; Belongs to the tRNA-modifying YgfZ family. | 0.555 |
| cvpA | ftsQ | HMPREF0758_2761 | HMPREF0758_0510 | CvpA family protein; COG: COG1286; Pfam: PF02674; InterPro: IPR003825. | Cell division protein FtsQ; Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly. | 0.472 |
| cvpA | holC | HMPREF0758_2761 | HMPREF0758_0746 | CvpA family protein; COG: COG1286; Pfam: PF02674; InterPro: IPR003825. | DNA polymerase III subunit chi; COG: COG2927; Pfam: PF04364; InterPro: IPR007459. | 0.611 |
| cvpA | yfcN | HMPREF0758_2761 | HMPREF0758_2725 | CvpA family protein; COG: COG1286; Pfam: PF02674; InterPro: IPR003825. | Smr domain protein; COG: COG2840; Pfam: PF01713; InterPro: IPR002625; Belongs to the UPF0115 family. | 0.562 |
| cvpA | ygfZ | HMPREF0758_2761 | HMPREF0758_2227 | CvpA family protein; COG: COG1286; Pfam: PF02674; InterPro: IPR003825. | Folate-binding protein YgfZ; Folate-binding protein involved in regulating the level of ATP-DnaA and in the modification of some tRNAs. It is probably a key factor in regulatory networks that act via tRNA modification, such as initiation of chromosomal replication; Belongs to the tRNA-modifying YgfZ family. | 0.558 |
| erpA | YggX | HMPREF0758_0491 | HMPREF0758_2105 | Iron-sulfur cluster assembly accessory protein; Required for insertion of 4Fe-4S clusters for at least IspG. | Bacterial Fe(2+) trafficking; Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and/or repair of Fe-S clusters in biosynthetic enzymes; Belongs to the Fe(2+)-trafficking protein family. | 0.425 |
| erpA | ygfZ | HMPREF0758_0491 | HMPREF0758_2227 | Iron-sulfur cluster assembly accessory protein; Required for insertion of 4Fe-4S clusters for at least IspG. | Folate-binding protein YgfZ; Folate-binding protein involved in regulating the level of ATP-DnaA and in the modification of some tRNAs. It is probably a key factor in regulatory networks that act via tRNA modification, such as initiation of chromosomal replication; Belongs to the tRNA-modifying YgfZ family. | 0.562 |
| erpA | yhgI | HMPREF0758_0491 | HMPREF0758_1052 | Iron-sulfur cluster assembly accessory protein; Required for insertion of 4Fe-4S clusters for at least IspG. | IscR-regulated protein YhgI; Involved in iron-sulfur cluster biogenesis. Binds a 4Fe-4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe/S proteins. Could also act as a scaffold/chaperone for damaged Fe/S proteins. | 0.668 |
| ftsQ | YggX | HMPREF0758_0510 | HMPREF0758_2105 | Cell division protein FtsQ; Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly. | Bacterial Fe(2+) trafficking; Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and/or repair of Fe-S clusters in biosynthetic enzymes; Belongs to the Fe(2+)-trafficking protein family. | 0.583 |
| ftsQ | cvpA | HMPREF0758_0510 | HMPREF0758_2761 | Cell division protein FtsQ; Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly. | CvpA family protein; COG: COG1286; Pfam: PF02674; InterPro: IPR003825. | 0.472 |
| ftsQ | hemD | HMPREF0758_0510 | HMPREF0758_1530 | Cell division protein FtsQ; Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly. | uroporphyrinogen-III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | 0.437 |
| ftsQ | holC | HMPREF0758_0510 | HMPREF0758_0746 | Cell division protein FtsQ; Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly. | DNA polymerase III subunit chi; COG: COG2927; Pfam: PF04364; InterPro: IPR007459. | 0.442 |
| ftsQ | secE | HMPREF0758_0510 | HMPREF0758_1656 | Cell division protein FtsQ; Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly. | Preprotein translocase, SecE subunit; Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation; Belongs to the SecE/SEC61-gamma family. | 0.826 |
| ftsQ | yfcN | HMPREF0758_0510 | HMPREF0758_2725 | Cell division protein FtsQ; Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly. | Smr domain protein; COG: COG2840; Pfam: PF01713; InterPro: IPR002625; Belongs to the UPF0115 family. | 0.521 |
| ftsQ | ygfZ | HMPREF0758_0510 | HMPREF0758_2227 | Cell division protein FtsQ; Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly. | Folate-binding protein YgfZ; Folate-binding protein involved in regulating the level of ATP-DnaA and in the modification of some tRNAs. It is probably a key factor in regulatory networks that act via tRNA modification, such as initiation of chromosomal replication; Belongs to the tRNA-modifying YgfZ family. | 0.559 |
| hemD | ftsQ | HMPREF0758_1530 | HMPREF0758_0510 | uroporphyrinogen-III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | Cell division protein FtsQ; Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly. | 0.437 |
| hemD | secE | HMPREF0758_1530 | HMPREF0758_1656 | uroporphyrinogen-III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | Preprotein translocase, SecE subunit; Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation; Belongs to the SecE/SEC61-gamma family. | 0.463 |