| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| EFE96035.1 | EFE96036.1 | HMPREF0758_2300 | HMPREF0758_2301 | Hypothetical protein; COG: COG4795. | Hypothetical protein. | 0.825 |
| EFE96035.1 | EFE96037.1 | HMPREF0758_2300 | HMPREF0758_2302 | Hypothetical protein; COG: COG4795. | Prepilin-type cleavage/methylation N-terminal domain protein; Pfam: PF07963. | 0.831 |
| EFE96035.1 | lgt | HMPREF0758_2300 | HMPREF0758_2297 | Hypothetical protein; COG: COG4795. | Prolipoprotein diacylglyceryl transferase; Catalyzes the transfer of the diacylglyceryl group from phosphatidylglycerol to the sulfhydryl group of the N-terminal cysteine of a prolipoprotein, the first step in the formation of mature lipoproteins; Belongs to the Lgt family. | 0.513 |
| EFE96035.1 | ppdA | HMPREF0758_2300 | HMPREF0758_2299 | Hypothetical protein; COG: COG4795. | Prepilin-type cleavage/methylation N-terminal domain protein; COG: COG2165; Pfam: PF07963. | 0.970 |
| EFE96035.1 | recC | HMPREF0758_2300 | HMPREF0758_2303 | Hypothetical protein; COG: COG4795. | Exodeoxyribonuclease V, gamma subunit; A helicase/nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and r [...] | 0.608 |
| EFE96035.1 | thyA | HMPREF0758_2300 | HMPREF0758_2298 | Hypothetical protein; COG: COG4795. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.525 |
| EFE96036.1 | EFE96035.1 | HMPREF0758_2301 | HMPREF0758_2300 | Hypothetical protein. | Hypothetical protein; COG: COG4795. | 0.825 |
| EFE96036.1 | EFE96037.1 | HMPREF0758_2301 | HMPREF0758_2302 | Hypothetical protein. | Prepilin-type cleavage/methylation N-terminal domain protein; Pfam: PF07963. | 0.830 |
| EFE96036.1 | lgt | HMPREF0758_2301 | HMPREF0758_2297 | Hypothetical protein. | Prolipoprotein diacylglyceryl transferase; Catalyzes the transfer of the diacylglyceryl group from phosphatidylglycerol to the sulfhydryl group of the N-terminal cysteine of a prolipoprotein, the first step in the formation of mature lipoproteins; Belongs to the Lgt family. | 0.498 |
| EFE96036.1 | ppdA | HMPREF0758_2301 | HMPREF0758_2299 | Hypothetical protein. | Prepilin-type cleavage/methylation N-terminal domain protein; COG: COG2165; Pfam: PF07963. | 0.772 |
| EFE96036.1 | recC | HMPREF0758_2301 | HMPREF0758_2303 | Hypothetical protein. | Exodeoxyribonuclease V, gamma subunit; A helicase/nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and r [...] | 0.601 |
| EFE96036.1 | thyA | HMPREF0758_2301 | HMPREF0758_2298 | Hypothetical protein. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.518 |
| EFE96037.1 | EFE96035.1 | HMPREF0758_2302 | HMPREF0758_2300 | Prepilin-type cleavage/methylation N-terminal domain protein; Pfam: PF07963. | Hypothetical protein; COG: COG4795. | 0.831 |
| EFE96037.1 | EFE96036.1 | HMPREF0758_2302 | HMPREF0758_2301 | Prepilin-type cleavage/methylation N-terminal domain protein; Pfam: PF07963. | Hypothetical protein. | 0.830 |
| EFE96037.1 | lgt | HMPREF0758_2302 | HMPREF0758_2297 | Prepilin-type cleavage/methylation N-terminal domain protein; Pfam: PF07963. | Prolipoprotein diacylglyceryl transferase; Catalyzes the transfer of the diacylglyceryl group from phosphatidylglycerol to the sulfhydryl group of the N-terminal cysteine of a prolipoprotein, the first step in the formation of mature lipoproteins; Belongs to the Lgt family. | 0.498 |
| EFE96037.1 | pilQ | HMPREF0758_2302 | HMPREF0758_1026 | Prepilin-type cleavage/methylation N-terminal domain protein; Pfam: PF07963. | Type IV pilus secretin PilQ; COG: COG4796; Pfam: PF07660,PF03958,PF00263; InterPro: IPR013355. | 0.401 |
| EFE96037.1 | ppdA | HMPREF0758_2302 | HMPREF0758_2299 | Prepilin-type cleavage/methylation N-terminal domain protein; Pfam: PF07963. | Prepilin-type cleavage/methylation N-terminal domain protein; COG: COG2165; Pfam: PF07963. | 0.782 |
| EFE96037.1 | rec | HMPREF0758_2302 | HMPREF0758_4381 | Prepilin-type cleavage/methylation N-terminal domain protein; Pfam: PF07963. | DNA internalization competence protein ComEC/Rec2-like protein; Pfam: PF03772,PF00753; InterPro: IPR004797. | 0.498 |
| EFE96037.1 | recC | HMPREF0758_2302 | HMPREF0758_2303 | Prepilin-type cleavage/methylation N-terminal domain protein; Pfam: PF07963. | Exodeoxyribonuclease V, gamma subunit; A helicase/nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and r [...] | 0.602 |
| EFE96037.1 | thyA | HMPREF0758_2302 | HMPREF0758_2298 | Prepilin-type cleavage/methylation N-terminal domain protein; Pfam: PF07963. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.520 |