STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
glnDprotein-P-II uridylyltransferase; Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen metabolism. (906 aa)    
Predicted Functional Partners:
glnB2
Nitrogen regulatory protein P-II; COG: COG0347; Pfam: PF00543; InterPro: IPR015867; Belongs to the P(II) protein family.
 
 
 0.984
glnB
Nitrogen regulatory protein P-II; COG: COG0347; Pfam: PF00543; InterPro: IPR015867; Belongs to the P(II) protein family.
 
 
 
 0.851
glnE
Bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of [...]
 
   
 0.814
map
Methionine aminopeptidase, type I; Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed; Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.
  
    0.736
gltB
Class II glutamine amidotransferase; COG: COG0069; Pfam: PF00310,PF04898,PF01645,PF01493; InterPro: IPR013785.
 
   
 0.646
glnL
ATPase/histidine kinase/DNA gyrase B/HSP90 domain protein; COG: COG3852; Pfam: PF00989,PF00512,PF02518; InterPro: IPR003594.
  
 
 
 0.621
dapD
2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase; COG: COG2171; Pfam: PF00132; InterPro: IPR005664; Belongs to the transferase hexapeptide repeat family.
     
 0.578
amt
Ammonium transporter; COG: COG0004; Pfam: PF00909; InterPro: IPR001905.
 
   
 0.543
mltB
Lytic murein transglycosylase B; COG: COG2951; InterPro: IPR011757.
  
     0.499
yaeT
Outer membrane protein assembly complex, YaeT protein; Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane. Constitutes, with BamD, the core component of the assembly machinery.
 
    0.485
Your Current Organism:
Serratia odorifera
NCBI taxonomy Id: 667129
Other names: S. odorifera DSM 4582, Serratia odorifera DSM 4582, Serratia odorifera str. DSM 4582, Serratia odorifera strain DSM 4582
Server load: medium (54%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.