| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| cdsA | lpxD | HMPREF0758_2337 | HMPREF0758_2341 | Phosphatidate cytidylyltransferase; COG: COG0575; Pfam: PF01148; InterPro: IPR000374; Belongs to the CDS family. | UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Catalyzes the N-acylation of UDP-3-O- (hydroxytetradecanoyl)glucosamine using 3-hydroxytetradecanoyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell; Belongs to the transferase hexapeptide repeat family. LpxD subfamily. | 0.545 |
| cdsA | rseP | HMPREF0758_2337 | HMPREF0758_2338 | Phosphatidate cytidylyltransferase; COG: COG0575; Pfam: PF01148; InterPro: IPR000374; Belongs to the CDS family. | RIP metalloprotease RseP; COG: COG0750; Pfam: PF02163,PF00595; InterPro: IPR004387. | 0.867 |
| cdsA | skp | HMPREF0758_2337 | HMPREF0758_2340 | Phosphatidate cytidylyltransferase; COG: COG0575; Pfam: PF01148; InterPro: IPR000374; Belongs to the CDS family. | Outer membrane protein; COG: COG2825; Pfam: PF03938; InterPro: IPR005632; Belongs to the skp family. | 0.445 |
| cdsA | uppS | HMPREF0758_2337 | HMPREF0758_2336 | Phosphatidate cytidylyltransferase; COG: COG0575; Pfam: PF01148; InterPro: IPR000374; Belongs to the CDS family. | Di-trans,poly-cis-decaprenylcistransferase; Catalyzes the sequential condensation of isopentenyl diphosphate (IPP) with (2E,6E)-farnesyl diphosphate (E,E-FPP) to yield (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30Z,34E,38E)-undecaprenyl diphosphate (di- trans,octa-cis-UPP). UPP is the precursor of glycosyl carrier lipid in the biosynthesis of bacterial cell wall polysaccharide components such as peptidoglycan and lipopolysaccharide. | 0.987 |
| cdsA | yaeT | HMPREF0758_2337 | HMPREF0758_2339 | Phosphatidate cytidylyltransferase; COG: COG0575; Pfam: PF01148; InterPro: IPR000374; Belongs to the CDS family. | Outer membrane protein assembly complex, YaeT protein; Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane. Constitutes, with BamD, the core component of the assembly machinery. | 0.676 |
| degS | gltB | HMPREF0758_1867 | HMPREF0758_1877 | Periplasmic serine peptidase DegS; COG: COG0265; Pfam: PF00089,PF00595; InterPro: IPR011783. | Class II glutamine amidotransferase; COG: COG0069; Pfam: PF00310,PF04898,PF01645,PF01493; InterPro: IPR013785. | 0.441 |
| degS | lepB | HMPREF0758_1867 | HMPREF0758_2454 | Periplasmic serine peptidase DegS; COG: COG0265; Pfam: PF00089,PF00595; InterPro: IPR011783. | Signal peptidase I; COG: COG0681; Pfam: PF00717; InterPro: IPR011056; Belongs to the peptidase S26 family. | 0.424 |
| degS | rseP | HMPREF0758_1867 | HMPREF0758_2338 | Periplasmic serine peptidase DegS; COG: COG0265; Pfam: PF00089,PF00595; InterPro: IPR011783. | RIP metalloprotease RseP; COG: COG0750; Pfam: PF02163,PF00595; InterPro: IPR004387. | 0.642 |
| gltB | degS | HMPREF0758_1877 | HMPREF0758_1867 | Class II glutamine amidotransferase; COG: COG0069; Pfam: PF00310,PF04898,PF01645,PF01493; InterPro: IPR013785. | Periplasmic serine peptidase DegS; COG: COG0265; Pfam: PF00089,PF00595; InterPro: IPR011783. | 0.441 |
| gltB | lepB | HMPREF0758_1877 | HMPREF0758_2454 | Class II glutamine amidotransferase; COG: COG0069; Pfam: PF00310,PF04898,PF01645,PF01493; InterPro: IPR013785. | Signal peptidase I; COG: COG0681; Pfam: PF00717; InterPro: IPR011056; Belongs to the peptidase S26 family. | 0.544 |
| gltB | rseP | HMPREF0758_1877 | HMPREF0758_2338 | Class II glutamine amidotransferase; COG: COG0069; Pfam: PF00310,PF04898,PF01645,PF01493; InterPro: IPR013785. | RIP metalloprotease RseP; COG: COG0750; Pfam: PF02163,PF00595; InterPro: IPR004387. | 0.592 |
| lepB | degS | HMPREF0758_2454 | HMPREF0758_1867 | Signal peptidase I; COG: COG0681; Pfam: PF00717; InterPro: IPR011056; Belongs to the peptidase S26 family. | Periplasmic serine peptidase DegS; COG: COG0265; Pfam: PF00089,PF00595; InterPro: IPR011783. | 0.424 |
| lepB | gltB | HMPREF0758_2454 | HMPREF0758_1877 | Signal peptidase I; COG: COG0681; Pfam: PF00717; InterPro: IPR011056; Belongs to the peptidase S26 family. | Class II glutamine amidotransferase; COG: COG0069; Pfam: PF00310,PF04898,PF01645,PF01493; InterPro: IPR013785. | 0.544 |
| lepB | rseP | HMPREF0758_2454 | HMPREF0758_2338 | Signal peptidase I; COG: COG0681; Pfam: PF00717; InterPro: IPR011056; Belongs to the peptidase S26 family. | RIP metalloprotease RseP; COG: COG0750; Pfam: PF02163,PF00595; InterPro: IPR004387. | 0.738 |
| lepB | uppS | HMPREF0758_2454 | HMPREF0758_2336 | Signal peptidase I; COG: COG0681; Pfam: PF00717; InterPro: IPR011056; Belongs to the peptidase S26 family. | Di-trans,poly-cis-decaprenylcistransferase; Catalyzes the sequential condensation of isopentenyl diphosphate (IPP) with (2E,6E)-farnesyl diphosphate (E,E-FPP) to yield (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30Z,34E,38E)-undecaprenyl diphosphate (di- trans,octa-cis-UPP). UPP is the precursor of glycosyl carrier lipid in the biosynthesis of bacterial cell wall polysaccharide components such as peptidoglycan and lipopolysaccharide. | 0.411 |
| lepB | yaeT | HMPREF0758_2454 | HMPREF0758_2339 | Signal peptidase I; COG: COG0681; Pfam: PF00717; InterPro: IPR011056; Belongs to the peptidase S26 family. | Outer membrane protein assembly complex, YaeT protein; Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane. Constitutes, with BamD, the core component of the assembly machinery. | 0.647 |
| lepB | yebA | HMPREF0758_2454 | HMPREF0758_3432 | Signal peptidase I; COG: COG0681; Pfam: PF00717; InterPro: IPR011056; Belongs to the peptidase S26 family. | Peptidase, M23 family; COG: COG0739; Pfam: PF01476,PF01551; InterPro: IPR002886. | 0.862 |
| lpxD | cdsA | HMPREF0758_2341 | HMPREF0758_2337 | UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Catalyzes the N-acylation of UDP-3-O- (hydroxytetradecanoyl)glucosamine using 3-hydroxytetradecanoyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell; Belongs to the transferase hexapeptide repeat family. LpxD subfamily. | Phosphatidate cytidylyltransferase; COG: COG0575; Pfam: PF01148; InterPro: IPR000374; Belongs to the CDS family. | 0.545 |
| lpxD | rseP | HMPREF0758_2341 | HMPREF0758_2338 | UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Catalyzes the N-acylation of UDP-3-O- (hydroxytetradecanoyl)glucosamine using 3-hydroxytetradecanoyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell; Belongs to the transferase hexapeptide repeat family. LpxD subfamily. | RIP metalloprotease RseP; COG: COG0750; Pfam: PF02163,PF00595; InterPro: IPR004387. | 0.611 |
| lpxD | skp | HMPREF0758_2341 | HMPREF0758_2340 | UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Catalyzes the N-acylation of UDP-3-O- (hydroxytetradecanoyl)glucosamine using 3-hydroxytetradecanoyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell; Belongs to the transferase hexapeptide repeat family. LpxD subfamily. | Outer membrane protein; COG: COG2825; Pfam: PF03938; InterPro: IPR005632; Belongs to the skp family. | 0.952 |