| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| YaeB | metQ | HMPREF0758_2364 | HMPREF0758_2366 | Methyltransferase, YaeB family; COG: COG1720; Pfam: PF01980; InterPro: IPR001378. | D-methionine-binding lipoprotein MetQ; COG: COG1464; Pfam: PF03180; InterPro: IPR004478; Belongs to the nlpA lipoprotein family. | 0.441 |
| YaeB | rcsF | HMPREF0758_2364 | HMPREF0758_2365 | Methyltransferase, YaeB family; COG: COG1720; Pfam: PF01980; InterPro: IPR001378. | Outer membrane lipoprotein; Essential component of the Rcs signaling system, which controls transcription of numerous genes. Plays a role in signal transduction from the cell surface to the histidine kinase RcsC. May detect outer membrane defects; Belongs to the RcsF family. | 0.794 |
| cysB2 | metG | HMPREF0758_4525 | HMPREF0758_4580 | Putative cystathionine beta-synthase; COG: COG0031; Pfam: PF00291,PF00571; InterPro: IPR001926. | methionine--tRNA ligase; Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation. | 0.433 |
| cysB2 | metH | HMPREF0758_4525 | HMPREF0758_1689 | Putative cystathionine beta-synthase; COG: COG0031; Pfam: PF00291,PF00571; InterPro: IPR001926. | 5-methyltetrahydrofolate--homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.948 |
| cysB2 | metQ | HMPREF0758_4525 | HMPREF0758_2366 | Putative cystathionine beta-synthase; COG: COG0031; Pfam: PF00291,PF00571; InterPro: IPR001926. | D-methionine-binding lipoprotein MetQ; COG: COG1464; Pfam: PF03180; InterPro: IPR004478; Belongs to the nlpA lipoprotein family. | 0.403 |
| cysB2 | metQ2 | HMPREF0758_4525 | HMPREF0758_4765 | Putative cystathionine beta-synthase; COG: COG0031; Pfam: PF00291,PF00571; InterPro: IPR001926. | Lipoprotein, YaeC family; COG: COG1464; Pfam: PF03180; InterPro: IPR004478; Belongs to the nlpA lipoprotein family. | 0.403 |
| gmhB | metI | HMPREF0758_2369 | HMPREF0758_2367 | D,D-heptose 1,7-bisphosphate phosphatase; COG: COG0241; Pfam: PF00702; InterPro: IPR004446. | ABC transporter, permease protein; COG: COG2011; Pfam: PF00528; InterPro: IPR000515. | 0.569 |
| gmhB | metN | HMPREF0758_2369 | HMPREF0758_2368 | D,D-heptose 1,7-bisphosphate phosphatase; COG: COG0241; Pfam: PF00702; InterPro: IPR004446. | D-methionine ABC transporter, ATP-binding protein; Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system. | 0.569 |
| gmhB | metQ | HMPREF0758_2369 | HMPREF0758_2366 | D,D-heptose 1,7-bisphosphate phosphatase; COG: COG0241; Pfam: PF00702; InterPro: IPR004446. | D-methionine-binding lipoprotein MetQ; COG: COG1464; Pfam: PF03180; InterPro: IPR004478; Belongs to the nlpA lipoprotein family. | 0.461 |
| metG | cysB2 | HMPREF0758_4580 | HMPREF0758_4525 | methionine--tRNA ligase; Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation. | Putative cystathionine beta-synthase; COG: COG0031; Pfam: PF00291,PF00571; InterPro: IPR001926. | 0.433 |
| metG | metH | HMPREF0758_4580 | HMPREF0758_1689 | methionine--tRNA ligase; Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation. | 5-methyltetrahydrofolate--homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.454 |
| metG | metQ | HMPREF0758_4580 | HMPREF0758_2366 | methionine--tRNA ligase; Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation. | D-methionine-binding lipoprotein MetQ; COG: COG1464; Pfam: PF03180; InterPro: IPR004478; Belongs to the nlpA lipoprotein family. | 0.401 |
| metG | metQ2 | HMPREF0758_4580 | HMPREF0758_4765 | methionine--tRNA ligase; Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation. | Lipoprotein, YaeC family; COG: COG1464; Pfam: PF03180; InterPro: IPR004478; Belongs to the nlpA lipoprotein family. | 0.401 |
| metH | cysB2 | HMPREF0758_1689 | HMPREF0758_4525 | 5-methyltetrahydrofolate--homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Putative cystathionine beta-synthase; COG: COG0031; Pfam: PF00291,PF00571; InterPro: IPR001926. | 0.948 |
| metH | metG | HMPREF0758_1689 | HMPREF0758_4580 | 5-methyltetrahydrofolate--homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | methionine--tRNA ligase; Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation. | 0.454 |
| metH | metN | HMPREF0758_1689 | HMPREF0758_2368 | 5-methyltetrahydrofolate--homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | D-methionine ABC transporter, ATP-binding protein; Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system. | 0.439 |
| metH | metQ | HMPREF0758_1689 | HMPREF0758_2366 | 5-methyltetrahydrofolate--homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | D-methionine-binding lipoprotein MetQ; COG: COG1464; Pfam: PF03180; InterPro: IPR004478; Belongs to the nlpA lipoprotein family. | 0.413 |
| metH | metQ2 | HMPREF0758_1689 | HMPREF0758_4765 | 5-methyltetrahydrofolate--homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Lipoprotein, YaeC family; COG: COG1464; Pfam: PF03180; InterPro: IPR004478; Belongs to the nlpA lipoprotein family. | 0.413 |
| metI | gmhB | HMPREF0758_2367 | HMPREF0758_2369 | ABC transporter, permease protein; COG: COG2011; Pfam: PF00528; InterPro: IPR000515. | D,D-heptose 1,7-bisphosphate phosphatase; COG: COG0241; Pfam: PF00702; InterPro: IPR004446. | 0.569 |
| metI | metN | HMPREF0758_2367 | HMPREF0758_2368 | ABC transporter, permease protein; COG: COG2011; Pfam: PF00528; InterPro: IPR000515. | D-methionine ABC transporter, ATP-binding protein; Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system. | 0.999 |