| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| bioC | metN | HMPREF0758_4780 | HMPREF0758_2368 | ABC-2 type transporter; COG: COG0842; Pfam: PF01061; InterPro: IPR013525. | D-methionine ABC transporter, ATP-binding protein; Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system. | 0.623 |
| cydD | metN | HMPREF0758_4453 | HMPREF0758_2368 | Thiol reductant ABC exporter, CydD subunit; COG: COG4988; Pfam: PF00664,PF00005; InterPro: IPR014216. | D-methionine ABC transporter, ATP-binding protein; Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system. | 0.657 |
| mdlA | metN | HMPREF0758_0188 | HMPREF0758_2368 | ABC transporter, ATP-binding protein; COG: COG1132; Pfam: PF00664,PF00005; InterPro: IPR001140. | D-methionine ABC transporter, ATP-binding protein; Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system. | 0.843 |
| metA | metF | HMPREF0758_1681 | HMPREF0758_1158 | Homoserine O-succinyltransferase; Transfers a succinyl group from succinyl-CoA to L-homoserine, forming succinyl-L-homoserine; Belongs to the MetA family. | Methylenetetrahydrofolate reductase (NAD(P)H); COG: COG0685; Pfam: PF02219; InterPro: IPR003171; Belongs to the methylenetetrahydrofolate reductase family. | 0.927 |
| metA | metI | HMPREF0758_1681 | HMPREF0758_2367 | Homoserine O-succinyltransferase; Transfers a succinyl group from succinyl-CoA to L-homoserine, forming succinyl-L-homoserine; Belongs to the MetA family. | ABC transporter, permease protein; COG: COG2011; Pfam: PF00528; InterPro: IPR000515. | 0.675 |
| metA | metK | HMPREF0758_1681 | HMPREF0758_2175 | Homoserine O-succinyltransferase; Transfers a succinyl group from succinyl-CoA to L-homoserine, forming succinyl-L-homoserine; Belongs to the MetA family. | Methionine adenosyltransferase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. | 0.627 |
| metA | metN | HMPREF0758_1681 | HMPREF0758_2368 | Homoserine O-succinyltransferase; Transfers a succinyl group from succinyl-CoA to L-homoserine, forming succinyl-L-homoserine; Belongs to the MetA family. | D-methionine ABC transporter, ATP-binding protein; Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system. | 0.676 |
| metF | metA | HMPREF0758_1158 | HMPREF0758_1681 | Methylenetetrahydrofolate reductase (NAD(P)H); COG: COG0685; Pfam: PF02219; InterPro: IPR003171; Belongs to the methylenetetrahydrofolate reductase family. | Homoserine O-succinyltransferase; Transfers a succinyl group from succinyl-CoA to L-homoserine, forming succinyl-L-homoserine; Belongs to the MetA family. | 0.927 |
| metF | metI | HMPREF0758_1158 | HMPREF0758_2367 | Methylenetetrahydrofolate reductase (NAD(P)H); COG: COG0685; Pfam: PF02219; InterPro: IPR003171; Belongs to the methylenetetrahydrofolate reductase family. | ABC transporter, permease protein; COG: COG2011; Pfam: PF00528; InterPro: IPR000515. | 0.518 |
| metF | metK | HMPREF0758_1158 | HMPREF0758_2175 | Methylenetetrahydrofolate reductase (NAD(P)H); COG: COG0685; Pfam: PF02219; InterPro: IPR003171; Belongs to the methylenetetrahydrofolate reductase family. | Methionine adenosyltransferase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. | 0.788 |
| metF | metN | HMPREF0758_1158 | HMPREF0758_2368 | Methylenetetrahydrofolate reductase (NAD(P)H); COG: COG0685; Pfam: PF02219; InterPro: IPR003171; Belongs to the methylenetetrahydrofolate reductase family. | D-methionine ABC transporter, ATP-binding protein; Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system. | 0.630 |
| metI | metA | HMPREF0758_2367 | HMPREF0758_1681 | ABC transporter, permease protein; COG: COG2011; Pfam: PF00528; InterPro: IPR000515. | Homoserine O-succinyltransferase; Transfers a succinyl group from succinyl-CoA to L-homoserine, forming succinyl-L-homoserine; Belongs to the MetA family. | 0.675 |
| metI | metF | HMPREF0758_2367 | HMPREF0758_1158 | ABC transporter, permease protein; COG: COG2011; Pfam: PF00528; InterPro: IPR000515. | Methylenetetrahydrofolate reductase (NAD(P)H); COG: COG0685; Pfam: PF02219; InterPro: IPR003171; Belongs to the methylenetetrahydrofolate reductase family. | 0.518 |
| metI | metN | HMPREF0758_2367 | HMPREF0758_2368 | ABC transporter, permease protein; COG: COG2011; Pfam: PF00528; InterPro: IPR000515. | D-methionine ABC transporter, ATP-binding protein; Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system. | 0.999 |
| metI | metQ | HMPREF0758_2367 | HMPREF0758_2366 | ABC transporter, permease protein; COG: COG2011; Pfam: PF00528; InterPro: IPR000515. | D-methionine-binding lipoprotein MetQ; COG: COG1464; Pfam: PF03180; InterPro: IPR004478; Belongs to the nlpA lipoprotein family. | 0.998 |
| metI | metQ2 | HMPREF0758_2367 | HMPREF0758_4765 | ABC transporter, permease protein; COG: COG2011; Pfam: PF00528; InterPro: IPR000515. | Lipoprotein, YaeC family; COG: COG1464; Pfam: PF03180; InterPro: IPR004478; Belongs to the nlpA lipoprotein family. | 0.997 |
| metK | metA | HMPREF0758_2175 | HMPREF0758_1681 | Methionine adenosyltransferase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. | Homoserine O-succinyltransferase; Transfers a succinyl group from succinyl-CoA to L-homoserine, forming succinyl-L-homoserine; Belongs to the MetA family. | 0.627 |
| metK | metF | HMPREF0758_2175 | HMPREF0758_1158 | Methionine adenosyltransferase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. | Methylenetetrahydrofolate reductase (NAD(P)H); COG: COG0685; Pfam: PF02219; InterPro: IPR003171; Belongs to the methylenetetrahydrofolate reductase family. | 0.788 |
| metK | metN | HMPREF0758_2175 | HMPREF0758_2368 | Methionine adenosyltransferase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. | D-methionine ABC transporter, ATP-binding protein; Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system. | 0.619 |
| metN | bioC | HMPREF0758_2368 | HMPREF0758_4780 | D-methionine ABC transporter, ATP-binding protein; Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system. | ABC-2 type transporter; COG: COG0842; Pfam: PF01061; InterPro: IPR013525. | 0.623 |