| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| EFE95963.1 | nrdH | HMPREF0758_2401 | HMPREF0758_2400 | Alkylhydroperoxidase AhpD family core domain protein; Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity. Belongs to the AhpD family. | Glutaredoxin; COG: COG0695; Pfam: PF00462; InterPro: IPR012335. | 0.449 |
| EFE95963.1 | nrdI | HMPREF0758_2401 | HMPREF0758_2399 | Alkylhydroperoxidase AhpD family core domain protein; Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity. Belongs to the AhpD family. | nrdI protein; Probably involved in ribonucleotide reductase function. | 0.432 |
| actP | msrA | HMPREF0758_0141 | HMPREF0758_0836 | Copper-exporting ATPase; COG: COG2217; Pfam: PF00403,PF00122,PF00702; InterPro: IPR001757. | Peptide-methionine (S)-S-oxide reductase; Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine. | 0.513 |
| actP | nrdH | HMPREF0758_0141 | HMPREF0758_2400 | Copper-exporting ATPase; COG: COG2217; Pfam: PF00403,PF00122,PF00702; InterPro: IPR001757. | Glutaredoxin; COG: COG0695; Pfam: PF00462; InterPro: IPR012335. | 0.522 |
| actP | rubA | HMPREF0758_0141 | HMPREF0758_0910 | Copper-exporting ATPase; COG: COG2217; Pfam: PF00403,PF00122,PF00702; InterPro: IPR001757. | Rubredoxin; COG: COG1773; Pfam: PF00301; InterPro: IPR004039; Belongs to the rubredoxin family. | 0.534 |
| actP | yhgI | HMPREF0758_0141 | HMPREF0758_1052 | Copper-exporting ATPase; COG: COG2217; Pfam: PF00403,PF00122,PF00702; InterPro: IPR001757. | IscR-regulated protein YhgI; Involved in iron-sulfur cluster biogenesis. Binds a 4Fe-4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe/S proteins. Could also act as a scaffold/chaperone for damaged Fe/S proteins. | 0.416 |
| msrA | actP | HMPREF0758_0836 | HMPREF0758_0141 | Peptide-methionine (S)-S-oxide reductase; Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine. | Copper-exporting ATPase; COG: COG2217; Pfam: PF00403,PF00122,PF00702; InterPro: IPR001757. | 0.513 |
| msrA | nrdH | HMPREF0758_0836 | HMPREF0758_2400 | Peptide-methionine (S)-S-oxide reductase; Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine. | Glutaredoxin; COG: COG0695; Pfam: PF00462; InterPro: IPR012335. | 0.409 |
| msrA | rubA | HMPREF0758_0836 | HMPREF0758_0910 | Peptide-methionine (S)-S-oxide reductase; Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine. | Rubredoxin; COG: COG1773; Pfam: PF00301; InterPro: IPR004039; Belongs to the rubredoxin family. | 0.426 |
| nrdA | nrdE | HMPREF0758_2829 | HMPREF0758_2398 | Ribonucleoside-diphosphate reductase, alpha subunit; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. | Ribonucleoside-diphosphate reductase, alpha subunit; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. | 0.900 |
| nrdA | nrdF | HMPREF0758_2829 | HMPREF0758_2397 | Ribonucleoside-diphosphate reductase, alpha subunit; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. | Ribonucleoside-diphosphate reductase, beta subunit; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides; Belongs to the ribonucleoside diphosphate reductase small chain family. | 0.987 |
| nrdA | nrdH | HMPREF0758_2829 | HMPREF0758_2400 | Ribonucleoside-diphosphate reductase, alpha subunit; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. | Glutaredoxin; COG: COG0695; Pfam: PF00462; InterPro: IPR012335. | 0.651 |
| nrdA | nrdI | HMPREF0758_2829 | HMPREF0758_2399 | Ribonucleoside-diphosphate reductase, alpha subunit; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. | nrdI protein; Probably involved in ribonucleotide reductase function. | 0.742 |
| nrdE | nrdA | HMPREF0758_2398 | HMPREF0758_2829 | Ribonucleoside-diphosphate reductase, alpha subunit; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. | Ribonucleoside-diphosphate reductase, alpha subunit; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. | 0.900 |
| nrdE | nrdF | HMPREF0758_2398 | HMPREF0758_2397 | Ribonucleoside-diphosphate reductase, alpha subunit; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. | Ribonucleoside-diphosphate reductase, beta subunit; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides; Belongs to the ribonucleoside diphosphate reductase small chain family. | 0.999 |
| nrdE | nrdH | HMPREF0758_2398 | HMPREF0758_2400 | Ribonucleoside-diphosphate reductase, alpha subunit; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. | Glutaredoxin; COG: COG0695; Pfam: PF00462; InterPro: IPR012335. | 0.969 |
| nrdE | nrdI | HMPREF0758_2398 | HMPREF0758_2399 | Ribonucleoside-diphosphate reductase, alpha subunit; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. | nrdI protein; Probably involved in ribonucleotide reductase function. | 0.977 |
| nrdF | nrdA | HMPREF0758_2397 | HMPREF0758_2829 | Ribonucleoside-diphosphate reductase, beta subunit; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides; Belongs to the ribonucleoside diphosphate reductase small chain family. | Ribonucleoside-diphosphate reductase, alpha subunit; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. | 0.987 |
| nrdF | nrdE | HMPREF0758_2397 | HMPREF0758_2398 | Ribonucleoside-diphosphate reductase, beta subunit; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides; Belongs to the ribonucleoside diphosphate reductase small chain family. | Ribonucleoside-diphosphate reductase, alpha subunit; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. | 0.999 |
| nrdF | nrdH | HMPREF0758_2397 | HMPREF0758_2400 | Ribonucleoside-diphosphate reductase, beta subunit; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides; Belongs to the ribonucleoside diphosphate reductase small chain family. | Glutaredoxin; COG: COG0695; Pfam: PF00462; InterPro: IPR012335. | 0.943 |