node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
DnaK_4 | cbpA | HMPREF0758_2576 | HMPREF0758_1043 | Putative chaperone; COG: COG0443; Pfam: PF00012. | DnaJ domain protein; COG: COG2214; Pfam: PF00226,PF01556; InterPro: IPR015609. | 0.802 |
DnaK_4 | dnaJ | HMPREF0758_2576 | HMPREF0758_0580 | Putative chaperone; COG: COG0443; Pfam: PF00012. | Chaperone protein DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, D [...] | 0.808 |
DnaK_4 | groL | HMPREF0758_2576 | HMPREF0758_0890 | Putative chaperone; COG: COG0443; Pfam: PF00012. | Chaperonin GroL; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. | 0.808 |
DnaK_4 | groS | HMPREF0758_2576 | HMPREF0758_0891 | Putative chaperone; COG: COG0443; Pfam: PF00012. | Chaperonin GroS; Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter. | 0.787 |
DnaK_4 | grpE | HMPREF0758_2576 | HMPREF0758_2441 | Putative chaperone; COG: COG0443; Pfam: PF00012. | Co-chaperone GrpE; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-depend [...] | 0.902 |
DnaK_4 | hslU | HMPREF0758_2576 | HMPREF0758_1169 | Putative chaperone; COG: COG0443; Pfam: PF00012. | ATP-dependent protease HslVU, ATPase subunit; ATPase subunit of a proteasome-like degradation complex; this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis. | 0.566 |
DnaK_4 | hslV | HMPREF0758_2576 | HMPREF0758_1168 | Putative chaperone; COG: COG0443; Pfam: PF00012. | ATP-dependent protease HslVU, peptidase subunit; Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery. | 0.456 |
DnaK_4 | lon | HMPREF0758_2576 | HMPREF0758_0199 | Putative chaperone; COG: COG0443; Pfam: PF00012. | Endopeptidase La; ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short- lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner. | 0.645 |
cbpA | DnaK_4 | HMPREF0758_1043 | HMPREF0758_2576 | DnaJ domain protein; COG: COG2214; Pfam: PF00226,PF01556; InterPro: IPR015609. | Putative chaperone; COG: COG0443; Pfam: PF00012. | 0.802 |
cbpA | dnaK | HMPREF0758_1043 | HMPREF0758_0581 | DnaJ domain protein; COG: COG2214; Pfam: PF00226,PF01556; InterPro: IPR015609. | Chaperone protein DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family. | 0.911 |
cbpA | groL | HMPREF0758_1043 | HMPREF0758_0890 | DnaJ domain protein; COG: COG2214; Pfam: PF00226,PF01556; InterPro: IPR015609. | Chaperonin GroL; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. | 0.770 |
cbpA | groS | HMPREF0758_1043 | HMPREF0758_0891 | DnaJ domain protein; COG: COG2214; Pfam: PF00226,PF01556; InterPro: IPR015609. | Chaperonin GroS; Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter. | 0.692 |
cbpA | grpE | HMPREF0758_1043 | HMPREF0758_2441 | DnaJ domain protein; COG: COG2214; Pfam: PF00226,PF01556; InterPro: IPR015609. | Co-chaperone GrpE; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-depend [...] | 0.909 |
cbpA | hscA | HMPREF0758_1043 | HMPREF0758_2490 | DnaJ domain protein; COG: COG2214; Pfam: PF00226,PF01556; InterPro: IPR015609. | Fe-S protein assembly chaperone HscA; Chaperone involved in the maturation of iron-sulfur cluster- containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB. Involved in the maturation of IscU. | 0.875 |
cbpA | hslU | HMPREF0758_1043 | HMPREF0758_1169 | DnaJ domain protein; COG: COG2214; Pfam: PF00226,PF01556; InterPro: IPR015609. | ATP-dependent protease HslVU, ATPase subunit; ATPase subunit of a proteasome-like degradation complex; this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis. | 0.665 |
cbpA | hslV | HMPREF0758_1043 | HMPREF0758_1168 | DnaJ domain protein; COG: COG2214; Pfam: PF00226,PF01556; InterPro: IPR015609. | ATP-dependent protease HslVU, peptidase subunit; Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery. | 0.597 |
cbpA | lon | HMPREF0758_1043 | HMPREF0758_0199 | DnaJ domain protein; COG: COG2214; Pfam: PF00226,PF01556; InterPro: IPR015609. | Endopeptidase La; ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short- lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner. | 0.622 |
dnaJ | DnaK_4 | HMPREF0758_0580 | HMPREF0758_2576 | Chaperone protein DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, D [...] | Putative chaperone; COG: COG0443; Pfam: PF00012. | 0.808 |
dnaJ | dnaK | HMPREF0758_0580 | HMPREF0758_0581 | Chaperone protein DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, D [...] | Chaperone protein DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family. | 0.996 |
dnaJ | groL | HMPREF0758_0580 | HMPREF0758_0890 | Chaperone protein DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, D [...] | Chaperonin GroL; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. | 0.895 |