STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
mclAAnti sigma-E protein RseA domain protein; An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic pro [...] (218 aa)    
Predicted Functional Partners:
rpoE
RNA polymerase sigma factor RpoE; COG: COG1595; Pfam: PF04542,PF08281; InterPro: IPR014286; Belongs to the sigma-70 factor family. ECF subfamily.
  
 
 0.994
rseB
MucB/RseB family protein; COG: COG3026; Pfam: PF03888; InterPro: IPR005588.
 
     0.931
rseC
Positive regulator of sigma(E), RseC/MucC; COG: COG3086; Pfam: PF04246; InterPro: IPR007359.
 
  
 0.887
FecI
Sigma-70 region 2; COG: COG1595; Pfam: PF04542,PF08281; InterPro: IPR014284; Belongs to the sigma-70 factor family.
  
 
 0.870
EFE95075.1
Hypothetical protein.
  
 
 0.843
degS
Periplasmic serine peptidase DegS; COG: COG0265; Pfam: PF00089,PF00595; InterPro: IPR011783.
  
 
 0.812
lapA
Hypothetical protein; Involved in the assembly of lipopolysaccharide (LPS). Belongs to the LapA family.
  
     0.764
lptC
Hypothetical protein; Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. Facilitates the transfer of LPS from the inner membrane to the periplasmic protein LptA. Could be a docking site for LptA. Belongs to the LptC family.
  
     0.761
EFE98159.1
Hypothetical protein; COG: COG3056; Pfam: PF03923; InterPro: IPR005619.
  
     0.736
EFE96700.1
Hypothetical protein; COG: COG3068; Pfam: PF04222; InterPro: IPR007338.
  
     0.735
Your Current Organism:
Serratia odorifera
NCBI taxonomy Id: 667129
Other names: S. odorifera DSM 4582, Serratia odorifera DSM 4582, Serratia odorifera str. DSM 4582, Serratia odorifera strain DSM 4582
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