| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| EFE96391.1 | igaA | HMPREF0758_1820 | HMPREF0758_1033 | TIGR02099 family protein; COG: COG3164; InterPro: IPR011836. | Intracellular growth attenuator protein IgaA; Pfam: PF07095; InterPro: IPR010771. | 0.770 |
| EFE96391.1 | nlpI | HMPREF0758_1820 | HMPREF0758_0800 | TIGR02099 family protein; COG: COG3164; InterPro: IPR011836. | Tetratricopeptide repeat protein; May be involved in cell division. | 0.548 |
| EFE96391.1 | rseC | HMPREF0758_1820 | HMPREF0758_2450 | TIGR02099 family protein; COG: COG3164; InterPro: IPR011836. | Positive regulator of sigma(E), RseC/MucC; COG: COG3086; Pfam: PF04246; InterPro: IPR007359. | 0.624 |
| igaA | EFE96391.1 | HMPREF0758_1033 | HMPREF0758_1820 | Intracellular growth attenuator protein IgaA; Pfam: PF07095; InterPro: IPR010771. | TIGR02099 family protein; COG: COG3164; InterPro: IPR011836. | 0.770 |
| igaA | nlpI | HMPREF0758_1033 | HMPREF0758_0800 | Intracellular growth attenuator protein IgaA; Pfam: PF07095; InterPro: IPR010771. | Tetratricopeptide repeat protein; May be involved in cell division. | 0.571 |
| igaA | rseC | HMPREF0758_1033 | HMPREF0758_2450 | Intracellular growth attenuator protein IgaA; Pfam: PF07095; InterPro: IPR010771. | Positive regulator of sigma(E), RseC/MucC; COG: COG3086; Pfam: PF04246; InterPro: IPR007359. | 0.631 |
| mclA | nadB | HMPREF0758_2448 | HMPREF0758_2446 | Anti sigma-E protein RseA domain protein; An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic pro [...] | L-aspartate oxidase; Catalyzes the oxidation of L-aspartate to iminoaspartate. | 0.498 |
| mclA | nlpI | HMPREF0758_2448 | HMPREF0758_0800 | Anti sigma-E protein RseA domain protein; An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic pro [...] | Tetratricopeptide repeat protein; May be involved in cell division. | 0.665 |
| mclA | rpoE | HMPREF0758_2448 | HMPREF0758_2447 | Anti sigma-E protein RseA domain protein; An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic pro [...] | RNA polymerase sigma factor RpoE; COG: COG1595; Pfam: PF04542,PF08281; InterPro: IPR014286; Belongs to the sigma-70 factor family. ECF subfamily. | 0.994 |
| mclA | rseB | HMPREF0758_2448 | HMPREF0758_2449 | Anti sigma-E protein RseA domain protein; An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic pro [...] | MucB/RseB family protein; COG: COG3026; Pfam: PF03888; InterPro: IPR005588. | 0.931 |
| mclA | rseC | HMPREF0758_2448 | HMPREF0758_2450 | Anti sigma-E protein RseA domain protein; An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic pro [...] | Positive regulator of sigma(E), RseC/MucC; COG: COG3086; Pfam: PF04246; InterPro: IPR007359. | 0.887 |
| nadB | mclA | HMPREF0758_2446 | HMPREF0758_2448 | L-aspartate oxidase; Catalyzes the oxidation of L-aspartate to iminoaspartate. | Anti sigma-E protein RseA domain protein; An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic pro [...] | 0.498 |
| nadB | rpoE | HMPREF0758_2446 | HMPREF0758_2447 | L-aspartate oxidase; Catalyzes the oxidation of L-aspartate to iminoaspartate. | RNA polymerase sigma factor RpoE; COG: COG1595; Pfam: PF04542,PF08281; InterPro: IPR014286; Belongs to the sigma-70 factor family. ECF subfamily. | 0.562 |
| nadB | rseB | HMPREF0758_2446 | HMPREF0758_2449 | L-aspartate oxidase; Catalyzes the oxidation of L-aspartate to iminoaspartate. | MucB/RseB family protein; COG: COG3026; Pfam: PF03888; InterPro: IPR005588. | 0.448 |
| nadB | rseC | HMPREF0758_2446 | HMPREF0758_2450 | L-aspartate oxidase; Catalyzes the oxidation of L-aspartate to iminoaspartate. | Positive regulator of sigma(E), RseC/MucC; COG: COG3086; Pfam: PF04246; InterPro: IPR007359. | 0.498 |
| nlpI | EFE96391.1 | HMPREF0758_0800 | HMPREF0758_1820 | Tetratricopeptide repeat protein; May be involved in cell division. | TIGR02099 family protein; COG: COG3164; InterPro: IPR011836. | 0.548 |
| nlpI | igaA | HMPREF0758_0800 | HMPREF0758_1033 | Tetratricopeptide repeat protein; May be involved in cell division. | Intracellular growth attenuator protein IgaA; Pfam: PF07095; InterPro: IPR010771. | 0.571 |
| nlpI | mclA | HMPREF0758_0800 | HMPREF0758_2448 | Tetratricopeptide repeat protein; May be involved in cell division. | Anti sigma-E protein RseA domain protein; An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic pro [...] | 0.665 |
| nlpI | rseC | HMPREF0758_0800 | HMPREF0758_2450 | Tetratricopeptide repeat protein; May be involved in cell division. | Positive regulator of sigma(E), RseC/MucC; COG: COG3086; Pfam: PF04246; InterPro: IPR007359. | 0.500 |
| rnfC | rnfD | HMPREF0758_3875 | HMPREF0758_3878 | Electron transport complex, RnfABCDGE type, C subunit; Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane. Belongs to the 4Fe4S bacterial-type ferredoxin family. RnfC subfamily. | Electron transport complex, RnfABCDGE type, D subunit; Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane. Belongs to the NqrB/RnfD family. | 0.986 |