node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
fdx-2 | hscA | HMPREF0758_2491 | HMPREF0758_2490 | Ferredoxin, 2Fe-2S type, ISC system; COG: COG0633; Pfam: PF00111; InterPro: IPR012675. | Fe-S protein assembly chaperone HscA; Chaperone involved in the maturation of iron-sulfur cluster- containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB. Involved in the maturation of IscU. | 0.982 |
fdx-2 | hscB | HMPREF0758_2491 | HMPREF0758_2489 | Ferredoxin, 2Fe-2S type, ISC system; COG: COG0633; Pfam: PF00111; InterPro: IPR012675. | Fe-S protein assembly co-chaperone HscB; Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA; Belongs to the HscB family. | 0.991 |
fdx-2 | iscA | HMPREF0758_2491 | HMPREF0758_2488 | Ferredoxin, 2Fe-2S type, ISC system; COG: COG0633; Pfam: PF00111; InterPro: IPR012675. | Iron-sulfur cluster assembly protein IscA; Is able to transfer iron-sulfur clusters to apo-ferredoxin. Multiple cycles of [2Fe2S] cluster formation and transfer are observed, suggesting that IscA acts catalytically. Recruits intracellular free iron so as to provide iron for the assembly of transient iron-sulfur cluster in IscU in the presence of IscS, L-cysteine and the thioredoxin reductase system TrxA/TrxB. | 0.932 |
fdx-2 | iscR | HMPREF0758_2491 | HMPREF0758_2485 | Ferredoxin, 2Fe-2S type, ISC system; COG: COG0633; Pfam: PF00111; InterPro: IPR012675. | Putative iron-sulfur cluster assembly transcription factor IscR; COG: COG1959; Pfam: PF02082; InterPro: IPR000944. | 0.677 |
fdx-2 | iscS | HMPREF0758_2491 | HMPREF0758_2486 | Ferredoxin, 2Fe-2S type, ISC system; COG: COG0633; Pfam: PF00111; InterPro: IPR012675. | Cysteine desulfurase IscS; Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins. | 0.968 |
fdx-2 | iscU | HMPREF0758_2491 | HMPREF0758_2487 | Ferredoxin, 2Fe-2S type, ISC system; COG: COG0633; Pfam: PF00111; InterPro: IPR012675. | FeS cluster assembly scaffold IscU; A scaffold on which IscS assembles Fe-S clusters. It is likely that Fe-S cluster coordination is flexible as the role of this complex is to build and then hand off Fe-S clusters. | 0.985 |
fdx-2 | iscX | HMPREF0758_2491 | HMPREF0758_2492 | Ferredoxin, 2Fe-2S type, ISC system; COG: COG0633; Pfam: PF00111; InterPro: IPR012675. | FeS assembly protein IscX; COG: COG2975; Pfam: PF04384; InterPro: IPR007479. | 0.989 |
grxD | iscA | HMPREF0758_3922 | HMPREF0758_2488 | Monothiol glutaredoxin, Grx4 family; COG: COG0278; Pfam: PF00462; InterPro: IPR012335; Belongs to the glutaredoxin family. Monothiol subfamily. | Iron-sulfur cluster assembly protein IscA; Is able to transfer iron-sulfur clusters to apo-ferredoxin. Multiple cycles of [2Fe2S] cluster formation and transfer are observed, suggesting that IscA acts catalytically. Recruits intracellular free iron so as to provide iron for the assembly of transient iron-sulfur cluster in IscU in the presence of IscS, L-cysteine and the thioredoxin reductase system TrxA/TrxB. | 0.558 |
grxD | iscU | HMPREF0758_3922 | HMPREF0758_2487 | Monothiol glutaredoxin, Grx4 family; COG: COG0278; Pfam: PF00462; InterPro: IPR012335; Belongs to the glutaredoxin family. Monothiol subfamily. | FeS cluster assembly scaffold IscU; A scaffold on which IscS assembles Fe-S clusters. It is likely that Fe-S cluster coordination is flexible as the role of this complex is to build and then hand off Fe-S clusters. | 0.501 |
hscA | fdx-2 | HMPREF0758_2490 | HMPREF0758_2491 | Fe-S protein assembly chaperone HscA; Chaperone involved in the maturation of iron-sulfur cluster- containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB. Involved in the maturation of IscU. | Ferredoxin, 2Fe-2S type, ISC system; COG: COG0633; Pfam: PF00111; InterPro: IPR012675. | 0.982 |
hscA | hscB | HMPREF0758_2490 | HMPREF0758_2489 | Fe-S protein assembly chaperone HscA; Chaperone involved in the maturation of iron-sulfur cluster- containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB. Involved in the maturation of IscU. | Fe-S protein assembly co-chaperone HscB; Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA; Belongs to the HscB family. | 0.991 |
hscA | iscA | HMPREF0758_2490 | HMPREF0758_2488 | Fe-S protein assembly chaperone HscA; Chaperone involved in the maturation of iron-sulfur cluster- containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB. Involved in the maturation of IscU. | Iron-sulfur cluster assembly protein IscA; Is able to transfer iron-sulfur clusters to apo-ferredoxin. Multiple cycles of [2Fe2S] cluster formation and transfer are observed, suggesting that IscA acts catalytically. Recruits intracellular free iron so as to provide iron for the assembly of transient iron-sulfur cluster in IscU in the presence of IscS, L-cysteine and the thioredoxin reductase system TrxA/TrxB. | 0.836 |
hscA | iscR | HMPREF0758_2490 | HMPREF0758_2485 | Fe-S protein assembly chaperone HscA; Chaperone involved in the maturation of iron-sulfur cluster- containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB. Involved in the maturation of IscU. | Putative iron-sulfur cluster assembly transcription factor IscR; COG: COG1959; Pfam: PF02082; InterPro: IPR000944. | 0.497 |
hscA | iscS | HMPREF0758_2490 | HMPREF0758_2486 | Fe-S protein assembly chaperone HscA; Chaperone involved in the maturation of iron-sulfur cluster- containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB. Involved in the maturation of IscU. | Cysteine desulfurase IscS; Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins. | 0.867 |
hscA | iscU | HMPREF0758_2490 | HMPREF0758_2487 | Fe-S protein assembly chaperone HscA; Chaperone involved in the maturation of iron-sulfur cluster- containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB. Involved in the maturation of IscU. | FeS cluster assembly scaffold IscU; A scaffold on which IscS assembles Fe-S clusters. It is likely that Fe-S cluster coordination is flexible as the role of this complex is to build and then hand off Fe-S clusters. | 0.956 |
hscA | iscX | HMPREF0758_2490 | HMPREF0758_2492 | Fe-S protein assembly chaperone HscA; Chaperone involved in the maturation of iron-sulfur cluster- containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB. Involved in the maturation of IscU. | FeS assembly protein IscX; COG: COG2975; Pfam: PF04384; InterPro: IPR007479. | 0.925 |
hscB | fdx-2 | HMPREF0758_2489 | HMPREF0758_2491 | Fe-S protein assembly co-chaperone HscB; Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA; Belongs to the HscB family. | Ferredoxin, 2Fe-2S type, ISC system; COG: COG0633; Pfam: PF00111; InterPro: IPR012675. | 0.991 |
hscB | hscA | HMPREF0758_2489 | HMPREF0758_2490 | Fe-S protein assembly co-chaperone HscB; Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA; Belongs to the HscB family. | Fe-S protein assembly chaperone HscA; Chaperone involved in the maturation of iron-sulfur cluster- containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB. Involved in the maturation of IscU. | 0.991 |
hscB | iscA | HMPREF0758_2489 | HMPREF0758_2488 | Fe-S protein assembly co-chaperone HscB; Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA; Belongs to the HscB family. | Iron-sulfur cluster assembly protein IscA; Is able to transfer iron-sulfur clusters to apo-ferredoxin. Multiple cycles of [2Fe2S] cluster formation and transfer are observed, suggesting that IscA acts catalytically. Recruits intracellular free iron so as to provide iron for the assembly of transient iron-sulfur cluster in IscU in the presence of IscS, L-cysteine and the thioredoxin reductase system TrxA/TrxB. | 0.957 |
hscB | iscR | HMPREF0758_2489 | HMPREF0758_2485 | Fe-S protein assembly co-chaperone HscB; Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA; Belongs to the HscB family. | Putative iron-sulfur cluster assembly transcription factor IscR; COG: COG1959; Pfam: PF02082; InterPro: IPR000944. | 0.910 |