| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| EFE93849.1 | pilF | HMPREF0758_4733 | HMPREF0758_2499 | Hypothetical protein. | Type IV pilus biogenesis/stability protein PilW; COG: COG3063; Pfam: PF07719,PF00515; InterPro: IPR013360. | 0.567 |
| EFE95867.1 | ispG | HMPREF0758_2503 | HMPREF0758_2501 | Hypothetical protein; COG: COG2976. | 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME- 2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate. Belongs to the IspG family. | 0.578 |
| EFE95867.1 | pilF | HMPREF0758_2503 | HMPREF0758_2499 | Hypothetical protein; COG: COG2976. | Type IV pilus biogenesis/stability protein PilW; COG: COG3063; Pfam: PF07719,PF00515; InterPro: IPR013360. | 0.606 |
| EFE95867.1 | rodZ | HMPREF0758_2503 | HMPREF0758_2500 | Hypothetical protein; COG: COG2976. | DNA-binding helix-turn-helix protein; Cytoskeletal protein that is involved in cell-shape control through regulation of the length of the long axis. | 0.643 |
| EFE95867.1 | yfgL | HMPREF0758_2503 | HMPREF0758_2504 | Hypothetical protein; COG: COG2976. | Outer membrane assembly lipoprotein YfgL; Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane. | 0.940 |
| EFE97922.1 | pilF | HMPREF0758_0506 | HMPREF0758_2499 | Hypothetical protein. | Type IV pilus biogenesis/stability protein PilW; COG: COG3063; Pfam: PF07719,PF00515; InterPro: IPR013360. | 0.716 |
| EFE97922.1 | priC | HMPREF0758_0506 | HMPREF0758_0166 | Hypothetical protein. | Primosomal replication protein priB and priC; COG: COG3923; Pfam: PF07445; InterPro: IPR010890. | 0.766 |
| ispG | EFE95867.1 | HMPREF0758_2501 | HMPREF0758_2503 | 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME- 2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate. Belongs to the IspG family. | Hypothetical protein; COG: COG2976. | 0.578 |
| ispG | pilF | HMPREF0758_2501 | HMPREF0758_2499 | 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME- 2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate. Belongs to the IspG family. | Type IV pilus biogenesis/stability protein PilW; COG: COG3063; Pfam: PF07719,PF00515; InterPro: IPR013360. | 0.655 |
| ispG | rlmN | HMPREF0758_2501 | HMPREF0758_2498 | 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME- 2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate. Belongs to the IspG family. | 23S rRNA m2A2503 methyltransferase; Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs. m2A2503 modification seems to play a crucial role in the proofreading step occurring at the peptidyl transferase center and thus would serve to optimize ribosomal fidelity; Belongs to the radical SAM superfamily. RlmN family. | 0.606 |
| ispG | rodZ | HMPREF0758_2501 | HMPREF0758_2500 | 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME- 2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate. Belongs to the IspG family. | DNA-binding helix-turn-helix protein; Cytoskeletal protein that is involved in cell-shape control through regulation of the length of the long axis. | 0.826 |
| ispG | yfgL | HMPREF0758_2501 | HMPREF0758_2504 | 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME- 2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate. Belongs to the IspG family. | Outer membrane assembly lipoprotein YfgL; Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane. | 0.521 |
| pilF | EFE93849.1 | HMPREF0758_2499 | HMPREF0758_4733 | Type IV pilus biogenesis/stability protein PilW; COG: COG3063; Pfam: PF07719,PF00515; InterPro: IPR013360. | Hypothetical protein. | 0.567 |
| pilF | EFE95867.1 | HMPREF0758_2499 | HMPREF0758_2503 | Type IV pilus biogenesis/stability protein PilW; COG: COG3063; Pfam: PF07719,PF00515; InterPro: IPR013360. | Hypothetical protein; COG: COG2976. | 0.606 |
| pilF | EFE97922.1 | HMPREF0758_2499 | HMPREF0758_0506 | Type IV pilus biogenesis/stability protein PilW; COG: COG3063; Pfam: PF07719,PF00515; InterPro: IPR013360. | Hypothetical protein. | 0.716 |
| pilF | ispG | HMPREF0758_2499 | HMPREF0758_2501 | Type IV pilus biogenesis/stability protein PilW; COG: COG3063; Pfam: PF07719,PF00515; InterPro: IPR013360. | 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME- 2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate. Belongs to the IspG family. | 0.655 |
| pilF | pilQ | HMPREF0758_2499 | HMPREF0758_1026 | Type IV pilus biogenesis/stability protein PilW; COG: COG3063; Pfam: PF07719,PF00515; InterPro: IPR013360. | Type IV pilus secretin PilQ; COG: COG4796; Pfam: PF07660,PF03958,PF00263; InterPro: IPR013355. | 0.635 |
| pilF | polA | HMPREF0758_2499 | HMPREF0758_1303 | Type IV pilus biogenesis/stability protein PilW; COG: COG3063; Pfam: PF07719,PF00515; InterPro: IPR013360. | DNA-directed DNA polymerase; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. | 0.590 |
| pilF | priC | HMPREF0758_2499 | HMPREF0758_0166 | Type IV pilus biogenesis/stability protein PilW; COG: COG3063; Pfam: PF07719,PF00515; InterPro: IPR013360. | Primosomal replication protein priB and priC; COG: COG3923; Pfam: PF07445; InterPro: IPR010890. | 0.530 |
| pilF | rlmN | HMPREF0758_2499 | HMPREF0758_2498 | Type IV pilus biogenesis/stability protein PilW; COG: COG3063; Pfam: PF07719,PF00515; InterPro: IPR013360. | 23S rRNA m2A2503 methyltransferase; Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs. m2A2503 modification seems to play a crucial role in the proofreading step occurring at the peptidyl transferase center and thus would serve to optimize ribosomal fidelity; Belongs to the radical SAM superfamily. RlmN family. | 0.598 |