| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| carA | carB | HMPREF0758_0566 | HMPREF0758_0565 | Carbamoyl-phosphate synthase, small subunit; COG: COG0505; Pfam: PF00988,PF00117; InterPro: IPR006274; Belongs to the CarA family. | Carbamoyl-phosphate synthase, large subunit; COG: COG0458; Pfam: PF00289,PF02786,PF02787,PF02142; InterPro: IPR006275; Belongs to the CarB family. | 0.999 |
| carA | iadA | HMPREF0758_0566 | HMPREF0758_0458 | Carbamoyl-phosphate synthase, small subunit; COG: COG0505; Pfam: PF00988,PF00117; InterPro: IPR006274; Belongs to the CarA family. | Beta-aspartyl peptidase; Catalyzes the hydrolytic cleavage of a subset of L- isoaspartyl (L-beta-aspartyl) dipeptides. Used to degrade proteins damaged by L-isoaspartyl residues formation. | 0.954 |
| carA | purL | HMPREF0758_0566 | HMPREF0758_2470 | Carbamoyl-phosphate synthase, small subunit; COG: COG0505; Pfam: PF00988,PF00117; InterPro: IPR006274; Belongs to the CarA family. | Phosphoribosylformylglycinamidine synthase; Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. | 0.961 |
| carA | pyrB | HMPREF0758_0566 | HMPREF0758_0752 | Carbamoyl-phosphate synthase, small subunit; COG: COG0505; Pfam: PF00988,PF00117; InterPro: IPR006274; Belongs to the CarA family. | Aspartate carbamoyltransferase; COG: COG0540; Pfam: PF02729,PF00185; InterPro: IPR002082; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family. | 0.999 |
| carA | pyrD | HMPREF0758_0566 | HMPREF0758_4352 | Carbamoyl-phosphate synthase, small subunit; COG: COG0505; Pfam: PF00988,PF00117; InterPro: IPR006274; Belongs to the CarA family. | Dihydroorotate oxidase; Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor; Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily. | 0.958 |
| carA | pyrE | HMPREF0758_0566 | HMPREF0758_1270 | Carbamoyl-phosphate synthase, small subunit; COG: COG0505; Pfam: PF00988,PF00117; InterPro: IPR006274; Belongs to the CarA family. | Orotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). | 0.950 |
| carA | pyrF | HMPREF0758_0566 | HMPREF0758_3580 | Carbamoyl-phosphate synthase, small subunit; COG: COG0505; Pfam: PF00988,PF00117; InterPro: IPR006274; Belongs to the CarA family. | Orotidine 5'-phosphate decarboxylase; Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP); Belongs to the OMP decarboxylase family. Type 1 subfamily. | 0.943 |
| carA | pyrP | HMPREF0758_0566 | HMPREF0758_2593 | Carbamoyl-phosphate synthase, small subunit; COG: COG0505; Pfam: PF00988,PF00117; InterPro: IPR006274; Belongs to the CarA family. | Putative permease; COG: COG2233; Pfam: PF00860; InterPro: IPR006042. | 0.686 |
| carA | upp | HMPREF0758_0566 | HMPREF0758_2592 | Carbamoyl-phosphate synthase, small subunit; COG: COG0505; Pfam: PF00988,PF00117; InterPro: IPR006274; Belongs to the CarA family. | Uracil phosphoribosyltransferase; Catalyzes the conversion of uracil and 5-phospho-alpha-D- ribose 1-diphosphate (PRPP) to UMP and diphosphate. | 0.529 |
| carB | carA | HMPREF0758_0565 | HMPREF0758_0566 | Carbamoyl-phosphate synthase, large subunit; COG: COG0458; Pfam: PF00289,PF02786,PF02787,PF02142; InterPro: IPR006275; Belongs to the CarB family. | Carbamoyl-phosphate synthase, small subunit; COG: COG0505; Pfam: PF00988,PF00117; InterPro: IPR006274; Belongs to the CarA family. | 0.999 |
| carB | iadA | HMPREF0758_0565 | HMPREF0758_0458 | Carbamoyl-phosphate synthase, large subunit; COG: COG0458; Pfam: PF00289,PF02786,PF02787,PF02142; InterPro: IPR006275; Belongs to the CarB family. | Beta-aspartyl peptidase; Catalyzes the hydrolytic cleavage of a subset of L- isoaspartyl (L-beta-aspartyl) dipeptides. Used to degrade proteins damaged by L-isoaspartyl residues formation. | 0.956 |
| carB | purL | HMPREF0758_0565 | HMPREF0758_2470 | Carbamoyl-phosphate synthase, large subunit; COG: COG0458; Pfam: PF00289,PF02786,PF02787,PF02142; InterPro: IPR006275; Belongs to the CarB family. | Phosphoribosylformylglycinamidine synthase; Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. | 0.659 |
| carB | pyrB | HMPREF0758_0565 | HMPREF0758_0752 | Carbamoyl-phosphate synthase, large subunit; COG: COG0458; Pfam: PF00289,PF02786,PF02787,PF02142; InterPro: IPR006275; Belongs to the CarB family. | Aspartate carbamoyltransferase; COG: COG0540; Pfam: PF02729,PF00185; InterPro: IPR002082; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family. | 0.999 |
| carB | pyrD | HMPREF0758_0565 | HMPREF0758_4352 | Carbamoyl-phosphate synthase, large subunit; COG: COG0458; Pfam: PF00289,PF02786,PF02787,PF02142; InterPro: IPR006275; Belongs to the CarB family. | Dihydroorotate oxidase; Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor; Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily. | 0.967 |
| carB | pyrE | HMPREF0758_0565 | HMPREF0758_1270 | Carbamoyl-phosphate synthase, large subunit; COG: COG0458; Pfam: PF00289,PF02786,PF02787,PF02142; InterPro: IPR006275; Belongs to the CarB family. | Orotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). | 0.957 |
| carB | pyrF | HMPREF0758_0565 | HMPREF0758_3580 | Carbamoyl-phosphate synthase, large subunit; COG: COG0458; Pfam: PF00289,PF02786,PF02787,PF02142; InterPro: IPR006275; Belongs to the CarB family. | Orotidine 5'-phosphate decarboxylase; Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP); Belongs to the OMP decarboxylase family. Type 1 subfamily. | 0.961 |
| carB | pyrP | HMPREF0758_0565 | HMPREF0758_2593 | Carbamoyl-phosphate synthase, large subunit; COG: COG0458; Pfam: PF00289,PF02786,PF02787,PF02142; InterPro: IPR006275; Belongs to the CarB family. | Putative permease; COG: COG2233; Pfam: PF00860; InterPro: IPR006042. | 0.684 |
| carB | upp | HMPREF0758_0565 | HMPREF0758_2592 | Carbamoyl-phosphate synthase, large subunit; COG: COG0458; Pfam: PF00289,PF02786,PF02787,PF02142; InterPro: IPR006275; Belongs to the CarB family. | Uracil phosphoribosyltransferase; Catalyzes the conversion of uracil and 5-phospho-alpha-D- ribose 1-diphosphate (PRPP) to UMP and diphosphate. | 0.510 |
| iadA | carA | HMPREF0758_0458 | HMPREF0758_0566 | Beta-aspartyl peptidase; Catalyzes the hydrolytic cleavage of a subset of L- isoaspartyl (L-beta-aspartyl) dipeptides. Used to degrade proteins damaged by L-isoaspartyl residues formation. | Carbamoyl-phosphate synthase, small subunit; COG: COG0505; Pfam: PF00988,PF00117; InterPro: IPR006274; Belongs to the CarA family. | 0.954 |
| iadA | carB | HMPREF0758_0458 | HMPREF0758_0565 | Beta-aspartyl peptidase; Catalyzes the hydrolytic cleavage of a subset of L- isoaspartyl (L-beta-aspartyl) dipeptides. Used to degrade proteins damaged by L-isoaspartyl residues formation. | Carbamoyl-phosphate synthase, large subunit; COG: COG0458; Pfam: PF00289,PF02786,PF02787,PF02142; InterPro: IPR006275; Belongs to the CarB family. | 0.956 |