| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ArgE_1 | argD | HMPREF0758_0312 | HMPREF0758_0999 | Peptidase, ArgE/DapE family; COG: COG0624; Pfam: PF01546,PF07687; InterPro: IPR002933. | Bifunctional N-succinyldiaminopimelate-aminotransferase/acetylornithine transaminase protein; Involved in both the arginine and lysine biosynthetic pathways; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily. | 0.918 |
| ArgE_1 | dapE | HMPREF0758_0312 | HMPREF0758_2609 | Peptidase, ArgE/DapE family; COG: COG0624; Pfam: PF01546,PF07687; InterPro: IPR002933. | Succinyl-diaminopimelate desuccinylase; Catalyzes the hydrolysis of N-succinyl-L,L-diaminopimelic acid (SDAP), forming succinate and LL-2,6-diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls; Belongs to the peptidase M20A family. DapE subfamily. | 0.935 |
| ArgE_1 | dapF | HMPREF0758_0312 | HMPREF0758_1535 | Peptidase, ArgE/DapE family; COG: COG0624; Pfam: PF01546,PF07687; InterPro: IPR002933. | Diaminopimelate epimerase; Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L- lysine and an essential component of the bacterial peptidoglycan. | 0.914 |
| EFE95752.1 | EFE95756.1 | HMPREF0758_2607 | HMPREF0758_2611 | Hypothetical protein. | Hypothetical protein. | 0.549 |
| EFE95752.1 | dapE | HMPREF0758_2607 | HMPREF0758_2609 | Hypothetical protein. | Succinyl-diaminopimelate desuccinylase; Catalyzes the hydrolysis of N-succinyl-L,L-diaminopimelic acid (SDAP), forming succinate and LL-2,6-diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls; Belongs to the peptidase M20A family. DapE subfamily. | 0.790 |
| EFE95752.1 | vanY | HMPREF0758_2607 | HMPREF0758_2608 | Hypothetical protein. | Serine-type D-Ala-D-Ala carboxypeptidase; COG: COG1876; Pfam: PF02557; InterPro: IPR003709. | 0.790 |
| EFE95752.1 | yffB | HMPREF0758_2607 | HMPREF0758_2610 | Hypothetical protein. | Transcriptional regulator, Spx/MgsR family; COG: COG1393; Pfam: PF03960; InterPro: IPR012335; Belongs to the ArsC family. | 0.802 |
| EFE95756.1 | EFE95752.1 | HMPREF0758_2611 | HMPREF0758_2607 | Hypothetical protein. | Hypothetical protein. | 0.549 |
| EFE95756.1 | dapE | HMPREF0758_2611 | HMPREF0758_2609 | Hypothetical protein. | Succinyl-diaminopimelate desuccinylase; Catalyzes the hydrolysis of N-succinyl-L,L-diaminopimelic acid (SDAP), forming succinate and LL-2,6-diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls; Belongs to the peptidase M20A family. DapE subfamily. | 0.549 |
| EFE95756.1 | vanY | HMPREF0758_2611 | HMPREF0758_2608 | Hypothetical protein. | Serine-type D-Ala-D-Ala carboxypeptidase; COG: COG1876; Pfam: PF02557; InterPro: IPR003709. | 0.549 |
| EFE95756.1 | yffB | HMPREF0758_2611 | HMPREF0758_2610 | Hypothetical protein. | Transcriptional regulator, Spx/MgsR family; COG: COG1393; Pfam: PF03960; InterPro: IPR012335; Belongs to the ArsC family. | 0.549 |
| argD | ArgE_1 | HMPREF0758_0999 | HMPREF0758_0312 | Bifunctional N-succinyldiaminopimelate-aminotransferase/acetylornithine transaminase protein; Involved in both the arginine and lysine biosynthetic pathways; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily. | Peptidase, ArgE/DapE family; COG: COG0624; Pfam: PF01546,PF07687; InterPro: IPR002933. | 0.918 |
| argD | dapE | HMPREF0758_0999 | HMPREF0758_2609 | Bifunctional N-succinyldiaminopimelate-aminotransferase/acetylornithine transaminase protein; Involved in both the arginine and lysine biosynthetic pathways; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily. | Succinyl-diaminopimelate desuccinylase; Catalyzes the hydrolysis of N-succinyl-L,L-diaminopimelic acid (SDAP), forming succinate and LL-2,6-diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls; Belongs to the peptidase M20A family. DapE subfamily. | 0.918 |
| dapE | ArgE_1 | HMPREF0758_2609 | HMPREF0758_0312 | Succinyl-diaminopimelate desuccinylase; Catalyzes the hydrolysis of N-succinyl-L,L-diaminopimelic acid (SDAP), forming succinate and LL-2,6-diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls; Belongs to the peptidase M20A family. DapE subfamily. | Peptidase, ArgE/DapE family; COG: COG0624; Pfam: PF01546,PF07687; InterPro: IPR002933. | 0.935 |
| dapE | EFE95752.1 | HMPREF0758_2609 | HMPREF0758_2607 | Succinyl-diaminopimelate desuccinylase; Catalyzes the hydrolysis of N-succinyl-L,L-diaminopimelic acid (SDAP), forming succinate and LL-2,6-diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls; Belongs to the peptidase M20A family. DapE subfamily. | Hypothetical protein. | 0.790 |
| dapE | EFE95756.1 | HMPREF0758_2609 | HMPREF0758_2611 | Succinyl-diaminopimelate desuccinylase; Catalyzes the hydrolysis of N-succinyl-L,L-diaminopimelic acid (SDAP), forming succinate and LL-2,6-diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls; Belongs to the peptidase M20A family. DapE subfamily. | Hypothetical protein. | 0.549 |
| dapE | argD | HMPREF0758_2609 | HMPREF0758_0999 | Succinyl-diaminopimelate desuccinylase; Catalyzes the hydrolysis of N-succinyl-L,L-diaminopimelic acid (SDAP), forming succinate and LL-2,6-diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls; Belongs to the peptidase M20A family. DapE subfamily. | Bifunctional N-succinyldiaminopimelate-aminotransferase/acetylornithine transaminase protein; Involved in both the arginine and lysine biosynthetic pathways; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily. | 0.918 |
| dapE | dapF | HMPREF0758_2609 | HMPREF0758_1535 | Succinyl-diaminopimelate desuccinylase; Catalyzes the hydrolysis of N-succinyl-L,L-diaminopimelic acid (SDAP), forming succinate and LL-2,6-diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls; Belongs to the peptidase M20A family. DapE subfamily. | Diaminopimelate epimerase; Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L- lysine and an essential component of the bacterial peptidoglycan. | 0.938 |
| dapE | dnaQ | HMPREF0758_2609 | HMPREF0758_0370 | Succinyl-diaminopimelate desuccinylase; Catalyzes the hydrolysis of N-succinyl-L,L-diaminopimelic acid (SDAP), forming succinate and LL-2,6-diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls; Belongs to the peptidase M20A family. DapE subfamily. | DNA polymerase III, epsilon subunit; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'- 5' exonuclease. | 0.558 |
| dapE | prmB | HMPREF0758_2609 | HMPREF0758_2726 | Succinyl-diaminopimelate desuccinylase; Catalyzes the hydrolysis of N-succinyl-L,L-diaminopimelic acid (SDAP), forming succinate and LL-2,6-diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls; Belongs to the peptidase M20A family. DapE subfamily. | (glutamine-N5) methyltransferase, ribosomal protein L3-specific; Specifically methylates the 50S ribosomal protein L3 on a specific glutamine residue; Belongs to the protein N5-glutamine methyltransferase family. PrmB subfamily. | 0.636 |