| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| EFE94700.1 | LsrB | HMPREF0758_3571 | HMPREF0758_1091 | Hypothetical protein. | Hypothetical protein; COG: COG1879. | 0.541 |
| EFE94700.1 | deoR | HMPREF0758_3571 | HMPREF0758_2630 | Hypothetical protein. | Putative sugar-binding domain protein; COG: COG2390; Pfam: PF04198; InterPro: IPR007324. | 0.461 |
| EFE95655.1 | deoR | HMPREF0758_2629 | HMPREF0758_2630 | Hypothetical protein; Pfam: PF02502; InterPro: IPR003500; 5.3.1.6. | Putative sugar-binding domain protein; COG: COG2390; Pfam: PF04198; InterPro: IPR007324. | 0.660 |
| LsrB | EFE94700.1 | HMPREF0758_1091 | HMPREF0758_3571 | Hypothetical protein; COG: COG1879. | Hypothetical protein. | 0.541 |
| LsrB | LsrF | HMPREF0758_1091 | HMPREF0758_3362 | Hypothetical protein; COG: COG1879. | Deoxyribose-phosphate aldolase; COG: COG1830; Pfam: PF01791; InterPro: IPR013785. | 0.908 |
| LsrB | deoR | HMPREF0758_1091 | HMPREF0758_2630 | Hypothetical protein; COG: COG1879. | Putative sugar-binding domain protein; COG: COG2390; Pfam: PF04198; InterPro: IPR007324. | 0.503 |
| LsrB | lsrG | HMPREF0758_1091 | HMPREF0758_4742 | Hypothetical protein; COG: COG1879. | Antibiotic biosynthesis monooxygenase; Involved in the degradation of phospho-AI-2, thereby terminating induction of the lsr operon and closing the AI-2 signaling cycle. Catalyzes the conversion of (4S)-4-hydroxy-5- phosphonooxypentane-2,3-dione (P-DPD) to 3-hydroxy-5- phosphonooxypentane-2,4-dione (P-HPD); Belongs to the LsrG family. | 0.920 |
| LsrB | lyxK | HMPREF0758_1091 | HMPREF0758_0621 | Hypothetical protein; COG: COG1879. | Carbohydrate kinase, FGGY family protein; COG: COG1070; Pfam: PF00370,PF02782; InterPro: IPR000577; Belongs to the FGGY kinase family. | 0.694 |
| LsrF | LsrB | HMPREF0758_3362 | HMPREF0758_1091 | Deoxyribose-phosphate aldolase; COG: COG1830; Pfam: PF01791; InterPro: IPR013785. | Hypothetical protein; COG: COG1879. | 0.908 |
| LsrF | deoR | HMPREF0758_3362 | HMPREF0758_2630 | Deoxyribose-phosphate aldolase; COG: COG1830; Pfam: PF01791; InterPro: IPR013785. | Putative sugar-binding domain protein; COG: COG2390; Pfam: PF04198; InterPro: IPR007324. | 0.417 |
| LsrF | lsrG | HMPREF0758_3362 | HMPREF0758_4742 | Deoxyribose-phosphate aldolase; COG: COG1830; Pfam: PF01791; InterPro: IPR013785. | Antibiotic biosynthesis monooxygenase; Involved in the degradation of phospho-AI-2, thereby terminating induction of the lsr operon and closing the AI-2 signaling cycle. Catalyzes the conversion of (4S)-4-hydroxy-5- phosphonooxypentane-2,3-dione (P-DPD) to 3-hydroxy-5- phosphonooxypentane-2,4-dione (P-HPD); Belongs to the LsrG family. | 0.921 |
| LsrF | lyxK | HMPREF0758_3362 | HMPREF0758_0621 | Deoxyribose-phosphate aldolase; COG: COG1830; Pfam: PF01791; InterPro: IPR013785. | Carbohydrate kinase, FGGY family protein; COG: COG1070; Pfam: PF00370,PF02782; InterPro: IPR000577; Belongs to the FGGY kinase family. | 0.494 |
| birA | deoR | HMPREF0758_1652 | HMPREF0758_2630 | biotin--[acetyl-CoA-carboxylase] ligase; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio-5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon. | Putative sugar-binding domain protein; COG: COG2390; Pfam: PF04198; InterPro: IPR007324. | 0.400 |
| deoR | EFE94700.1 | HMPREF0758_2630 | HMPREF0758_3571 | Putative sugar-binding domain protein; COG: COG2390; Pfam: PF04198; InterPro: IPR007324. | Hypothetical protein. | 0.461 |
| deoR | EFE95655.1 | HMPREF0758_2630 | HMPREF0758_2629 | Putative sugar-binding domain protein; COG: COG2390; Pfam: PF04198; InterPro: IPR007324. | Hypothetical protein; Pfam: PF02502; InterPro: IPR003500; 5.3.1.6. | 0.660 |
| deoR | LsrB | HMPREF0758_2630 | HMPREF0758_1091 | Putative sugar-binding domain protein; COG: COG2390; Pfam: PF04198; InterPro: IPR007324. | Hypothetical protein; COG: COG1879. | 0.503 |
| deoR | LsrF | HMPREF0758_2630 | HMPREF0758_3362 | Putative sugar-binding domain protein; COG: COG2390; Pfam: PF04198; InterPro: IPR007324. | Deoxyribose-phosphate aldolase; COG: COG1830; Pfam: PF01791; InterPro: IPR013785. | 0.417 |
| deoR | birA | HMPREF0758_2630 | HMPREF0758_1652 | Putative sugar-binding domain protein; COG: COG2390; Pfam: PF04198; InterPro: IPR007324. | biotin--[acetyl-CoA-carboxylase] ligase; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio-5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon. | 0.400 |
| deoR | dhaM | HMPREF0758_2630 | HMPREF0758_1953 | Putative sugar-binding domain protein; COG: COG2390; Pfam: PF04198; InterPro: IPR007324. | Dihydroxyacetone kinase, phosphotransfer subunit; COG: COG3412; Pfam: PF03610,PF00381,PF05524,PF00391; InterPro: IPR012844; Belongs to the PEP-utilizing enzyme family. | 0.433 |
| deoR | gutB | HMPREF0758_2630 | HMPREF0758_0625 | Putative sugar-binding domain protein; COG: COG2390; Pfam: PF04198; InterPro: IPR007324. | Putative chlorophyll synthesis pathway protein BchC; COG: COG1063; Pfam: PF08240,PF00107; InterPro: IPR002085. | 0.409 |