| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| EFE95690.1 | ligA-2 | HMPREF0758_2664 | HMPREF0758_2663 | Hypothetical protein; COG: COG3530. | DNA ligase (NAD+); DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double- stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA; Belongs to the NAD-dependent DNA ligase family. LigA subfamily. | 0.780 |
| EFE95690.1 | zipA | HMPREF0758_2664 | HMPREF0758_2662 | Hypothetical protein; COG: COG3530. | ZipA, C-terminal FtsZ-binding domain protein; Essential cell division protein that stabilizes the FtsZ protofilaments by cross-linking them and that serves as a cytoplasmic membrane anchor for the Z ring. Also required for the recruitment to the septal ring of downstream cell division proteins. | 0.570 |
| EFE96942.1 | ftsL | HMPREF0758_1536 | HMPREF0758_0521 | Hypothetical protein; COG: COG3159; Pfam: PF04340; InterPro: IPR007435. | Cell division protein FtsL; Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. | 0.574 |
| EFE96942.1 | rodZ | HMPREF0758_1536 | HMPREF0758_2500 | Hypothetical protein; COG: COG3159; Pfam: PF04340; InterPro: IPR007435. | DNA-binding helix-turn-helix protein; Cytoskeletal protein that is involved in cell-shape control through regulation of the length of the long axis. | 0.492 |
| EFE96942.1 | zipA | HMPREF0758_1536 | HMPREF0758_2662 | Hypothetical protein; COG: COG3159; Pfam: PF04340; InterPro: IPR007435. | ZipA, C-terminal FtsZ-binding domain protein; Essential cell division protein that stabilizes the FtsZ protofilaments by cross-linking them and that serves as a cytoplasmic membrane anchor for the Z ring. Also required for the recruitment to the septal ring of downstream cell division proteins. | 0.602 |
| ftsB | ftsL | HMPREF0758_0440 | HMPREF0758_0521 | Cell division protein FtsB; Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. | Cell division protein FtsL; Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. | 0.933 |
| ftsB | ftsQ | HMPREF0758_0440 | HMPREF0758_0510 | Cell division protein FtsB; Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. | Cell division protein FtsQ; Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly. | 0.980 |
| ftsB | ftsZ | HMPREF0758_0440 | HMPREF0758_0508 | Cell division protein FtsB; Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. | Cell division protein FtsZ; Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity. | 0.429 |
| ftsB | mreD | HMPREF0758_0440 | HMPREF0758_1817 | Cell division protein FtsB; Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. | Rod shape-determining protein MreD; Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins. Belongs to the MreD family. | 0.615 |
| ftsB | rodZ | HMPREF0758_0440 | HMPREF0758_2500 | Cell division protein FtsB; Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. | DNA-binding helix-turn-helix protein; Cytoskeletal protein that is involved in cell-shape control through regulation of the length of the long axis. | 0.531 |
| ftsB | zipA | HMPREF0758_0440 | HMPREF0758_2662 | Cell division protein FtsB; Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. | ZipA, C-terminal FtsZ-binding domain protein; Essential cell division protein that stabilizes the FtsZ protofilaments by cross-linking them and that serves as a cytoplasmic membrane anchor for the Z ring. Also required for the recruitment to the septal ring of downstream cell division proteins. | 0.586 |
| ftsL | EFE96942.1 | HMPREF0758_0521 | HMPREF0758_1536 | Cell division protein FtsL; Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. | Hypothetical protein; COG: COG3159; Pfam: PF04340; InterPro: IPR007435. | 0.574 |
| ftsL | ftsB | HMPREF0758_0521 | HMPREF0758_0440 | Cell division protein FtsL; Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. | Cell division protein FtsB; Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. | 0.933 |
| ftsL | ftsQ | HMPREF0758_0521 | HMPREF0758_0510 | Cell division protein FtsL; Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. | Cell division protein FtsQ; Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly. | 0.989 |
| ftsL | ftsZ | HMPREF0758_0521 | HMPREF0758_0508 | Cell division protein FtsL; Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. | Cell division protein FtsZ; Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity. | 0.565 |
| ftsL | mreD | HMPREF0758_0521 | HMPREF0758_1817 | Cell division protein FtsL; Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. | Rod shape-determining protein MreD; Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins. Belongs to the MreD family. | 0.633 |
| ftsL | rodZ | HMPREF0758_0521 | HMPREF0758_2500 | Cell division protein FtsL; Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. | DNA-binding helix-turn-helix protein; Cytoskeletal protein that is involved in cell-shape control through regulation of the length of the long axis. | 0.604 |
| ftsL | zipA | HMPREF0758_0521 | HMPREF0758_2662 | Cell division protein FtsL; Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. | ZipA, C-terminal FtsZ-binding domain protein; Essential cell division protein that stabilizes the FtsZ protofilaments by cross-linking them and that serves as a cytoplasmic membrane anchor for the Z ring. Also required for the recruitment to the septal ring of downstream cell division proteins. | 0.718 |
| ftsQ | ftsB | HMPREF0758_0510 | HMPREF0758_0440 | Cell division protein FtsQ; Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly. | Cell division protein FtsB; Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. | 0.980 |
| ftsQ | ftsL | HMPREF0758_0510 | HMPREF0758_0521 | Cell division protein FtsQ; Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly. | Cell division protein FtsL; Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. | 0.989 |