| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| asd2 | dapA | HMPREF0758_2755 | HMPREF0758_2601 | Semialdehyde dehydrogenase, dimerization domain protein; COG: COG0136; Pfam: PF01118,PF02774; InterPro: IPR012280; Belongs to the aspartate-semialdehyde dehydrogenase family. | Dihydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). | 0.779 |
| asd2 | dapA-2 | HMPREF0758_2755 | HMPREF0758_3895 | Semialdehyde dehydrogenase, dimerization domain protein; COG: COG0136; Pfam: PF01118,PF02774; InterPro: IPR012280; Belongs to the aspartate-semialdehyde dehydrogenase family. | Dihydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). | 0.804 |
| asd2 | dapF | HMPREF0758_2755 | HMPREF0758_1535 | Semialdehyde dehydrogenase, dimerization domain protein; COG: COG0136; Pfam: PF01118,PF02774; InterPro: IPR012280; Belongs to the aspartate-semialdehyde dehydrogenase family. | Diaminopimelate epimerase; Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L- lysine and an essential component of the bacterial peptidoglycan. | 0.690 |
| asd2 | gltB | HMPREF0758_2755 | HMPREF0758_1877 | Semialdehyde dehydrogenase, dimerization domain protein; COG: COG0136; Pfam: PF01118,PF02774; InterPro: IPR012280; Belongs to the aspartate-semialdehyde dehydrogenase family. | Class II glutamine amidotransferase; COG: COG0069; Pfam: PF00310,PF04898,PF01645,PF01493; InterPro: IPR013785. | 0.647 |
| asd2 | lysC | HMPREF0758_2755 | HMPREF0758_1691 | Semialdehyde dehydrogenase, dimerization domain protein; COG: COG0136; Pfam: PF01118,PF02774; InterPro: IPR012280; Belongs to the aspartate-semialdehyde dehydrogenase family. | Aspartate kinase, monofunctional class; COG: COG0527; Pfam: PF00696,PF01842; InterPro: IPR005260; Belongs to the aspartokinase family. | 0.843 |
| asd2 | metL | HMPREF0758_2755 | HMPREF0758_1159 | Semialdehyde dehydrogenase, dimerization domain protein; COG: COG0136; Pfam: PF01118,PF02774; InterPro: IPR012280; Belongs to the aspartate-semialdehyde dehydrogenase family. | Homoserine dehydrogenase; COG: COG0460; Pfam: PF00742; InterPro: IPR001342. | 0.897 |
| asd2 | metM2 | HMPREF0758_2755 | HMPREF0758_1160 | Semialdehyde dehydrogenase, dimerization domain protein; COG: COG0136; Pfam: PF01118,PF02774; InterPro: IPR012280; Belongs to the aspartate-semialdehyde dehydrogenase family. | Amino acid kinase family; COG: COG0527; Pfam: PF00696; InterPro: IPR001341. | 0.924 |
| asd2 | pdxB-2 | HMPREF0758_2755 | HMPREF0758_2754 | Semialdehyde dehydrogenase, dimerization domain protein; COG: COG0136; Pfam: PF01118,PF02774; InterPro: IPR012280; Belongs to the aspartate-semialdehyde dehydrogenase family. | 4-phosphoerythronate dehydrogenase; Catalyzes the oxidation of erythronate-4-phosphate to 3- hydroxy-2-oxo-4-phosphonooxybutanoate. | 0.644 |
| asd2 | thrA | HMPREF0758_2755 | HMPREF0758_0591 | Semialdehyde dehydrogenase, dimerization domain protein; COG: COG0136; Pfam: PF01118,PF02774; InterPro: IPR012280; Belongs to the aspartate-semialdehyde dehydrogenase family. | Homoserine dehydrogenase; COG: COG0527; Pfam: PF00696,PF01842,PF03447,PF00742; InterPro: IPR001341; In the C-terminal section; belongs to the homoserine dehydrogenase family. | 0.946 |
| asd2 | truA | HMPREF0758_2755 | HMPREF0758_2756 | Semialdehyde dehydrogenase, dimerization domain protein; COG: COG0136; Pfam: PF01118,PF02774; InterPro: IPR012280; Belongs to the aspartate-semialdehyde dehydrogenase family. | tRNA pseudouridine synthase A; Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs. | 0.847 |
| dapA | asd2 | HMPREF0758_2601 | HMPREF0758_2755 | Dihydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). | Semialdehyde dehydrogenase, dimerization domain protein; COG: COG0136; Pfam: PF01118,PF02774; InterPro: IPR012280; Belongs to the aspartate-semialdehyde dehydrogenase family. | 0.779 |
| dapA | dapA-2 | HMPREF0758_2601 | HMPREF0758_3895 | Dihydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). | Dihydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). | 0.920 |
| dapA | dapF | HMPREF0758_2601 | HMPREF0758_1535 | Dihydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). | Diaminopimelate epimerase; Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L- lysine and an essential component of the bacterial peptidoglycan. | 0.669 |
| dapA | lysC | HMPREF0758_2601 | HMPREF0758_1691 | Dihydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). | Aspartate kinase, monofunctional class; COG: COG0527; Pfam: PF00696,PF01842; InterPro: IPR005260; Belongs to the aspartokinase family. | 0.469 |
| dapA | metL | HMPREF0758_2601 | HMPREF0758_1159 | Dihydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). | Homoserine dehydrogenase; COG: COG0460; Pfam: PF00742; InterPro: IPR001342. | 0.548 |
| dapA | metM2 | HMPREF0758_2601 | HMPREF0758_1160 | Dihydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). | Amino acid kinase family; COG: COG0527; Pfam: PF00696; InterPro: IPR001341. | 0.967 |
| dapA | thrA | HMPREF0758_2601 | HMPREF0758_0591 | Dihydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). | Homoserine dehydrogenase; COG: COG0527; Pfam: PF00696,PF01842,PF03447,PF00742; InterPro: IPR001341; In the C-terminal section; belongs to the homoserine dehydrogenase family. | 0.952 |
| dapA-2 | asd2 | HMPREF0758_3895 | HMPREF0758_2755 | Dihydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). | Semialdehyde dehydrogenase, dimerization domain protein; COG: COG0136; Pfam: PF01118,PF02774; InterPro: IPR012280; Belongs to the aspartate-semialdehyde dehydrogenase family. | 0.804 |
| dapA-2 | dapA | HMPREF0758_3895 | HMPREF0758_2601 | Dihydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). | Dihydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). | 0.920 |
| dapA-2 | dapF | HMPREF0758_3895 | HMPREF0758_1535 | Dihydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). | Diaminopimelate epimerase; Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L- lysine and an essential component of the bacterial peptidoglycan. | 0.614 |