| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| cvpA | purF | HMPREF0758_2761 | HMPREF0758_2762 | CvpA family protein; COG: COG1286; Pfam: PF02674; InterPro: IPR003825. | Amidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine; In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family. | 0.975 |
| cvpA | ubiX | HMPREF0758_2761 | HMPREF0758_2763 | CvpA family protein; COG: COG1286; Pfam: PF02674; InterPro: IPR003825. | Polyprenyl P-hydroxybenzoate and phenylacrylic acid decarboxylase; Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3-polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN; Belongs to the UbiX/PAD1 family. | 0.498 |
| hisJ | ubiX | HMPREF0758_2764 | HMPREF0758_2763 | Lysine-arginine-ornithine-binding periplasmic protein; COG: COG0834; Pfam: PF00497; InterPro: IPR005768; Belongs to the bacterial solute-binding protein 3 family. | Polyprenyl P-hydroxybenzoate and phenylacrylic acid decarboxylase; Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3-polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN; Belongs to the UbiX/PAD1 family. | 0.405 |
| purF | cvpA | HMPREF0758_2762 | HMPREF0758_2761 | Amidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine; In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family. | CvpA family protein; COG: COG1286; Pfam: PF02674; InterPro: IPR003825. | 0.975 |
| purF | ubiX | HMPREF0758_2762 | HMPREF0758_2763 | Amidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine; In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family. | Polyprenyl P-hydroxybenzoate and phenylacrylic acid decarboxylase; Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3-polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN; Belongs to the UbiX/PAD1 family. | 0.534 |
| ubiA | ubiD | HMPREF0758_1705 | HMPREF0758_1642 | 4-hydroxybenzoate polyprenyl transferase; Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3-octaprenyl-4-hydroxybenzoate. | UbiD family decarboxylase; Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol, an intermediate step in ubiquinone biosynthesis. | 0.958 |
| ubiA | ubiF | HMPREF0758_1705 | HMPREF0758_2213 | 4-hydroxybenzoate polyprenyl transferase; Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3-octaprenyl-4-hydroxybenzoate. | Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; COG: COG0654; Pfam: PF01266; InterPro: IPR010971. | 0.773 |
| ubiA | ubiX | HMPREF0758_1705 | HMPREF0758_2763 | 4-hydroxybenzoate polyprenyl transferase; Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3-octaprenyl-4-hydroxybenzoate. | Polyprenyl P-hydroxybenzoate and phenylacrylic acid decarboxylase; Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3-polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN; Belongs to the UbiX/PAD1 family. | 0.951 |
| ubiD | ubiA | HMPREF0758_1642 | HMPREF0758_1705 | UbiD family decarboxylase; Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol, an intermediate step in ubiquinone biosynthesis. | 4-hydroxybenzoate polyprenyl transferase; Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3-octaprenyl-4-hydroxybenzoate. | 0.958 |
| ubiD | ubiF | HMPREF0758_1642 | HMPREF0758_2213 | UbiD family decarboxylase; Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol, an intermediate step in ubiquinone biosynthesis. | Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; COG: COG0654; Pfam: PF01266; InterPro: IPR010971. | 0.924 |
| ubiD | ubiX | HMPREF0758_1642 | HMPREF0758_2763 | UbiD family decarboxylase; Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol, an intermediate step in ubiquinone biosynthesis. | Polyprenyl P-hydroxybenzoate and phenylacrylic acid decarboxylase; Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3-polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN; Belongs to the UbiX/PAD1 family. | 0.993 |
| ubiF | ubiA | HMPREF0758_2213 | HMPREF0758_1705 | Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; COG: COG0654; Pfam: PF01266; InterPro: IPR010971. | 4-hydroxybenzoate polyprenyl transferase; Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3-octaprenyl-4-hydroxybenzoate. | 0.773 |
| ubiF | ubiD | HMPREF0758_2213 | HMPREF0758_1642 | Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; COG: COG0654; Pfam: PF01266; InterPro: IPR010971. | UbiD family decarboxylase; Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol, an intermediate step in ubiquinone biosynthesis. | 0.924 |
| ubiF | ubiX | HMPREF0758_2213 | HMPREF0758_2763 | Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; COG: COG0654; Pfam: PF01266; InterPro: IPR010971. | Polyprenyl P-hydroxybenzoate and phenylacrylic acid decarboxylase; Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3-polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN; Belongs to the UbiX/PAD1 family. | 0.912 |
| ubiX | cvpA | HMPREF0758_2763 | HMPREF0758_2761 | Polyprenyl P-hydroxybenzoate and phenylacrylic acid decarboxylase; Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3-polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN; Belongs to the UbiX/PAD1 family. | CvpA family protein; COG: COG1286; Pfam: PF02674; InterPro: IPR003825. | 0.498 |
| ubiX | hisJ | HMPREF0758_2763 | HMPREF0758_2764 | Polyprenyl P-hydroxybenzoate and phenylacrylic acid decarboxylase; Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3-polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN; Belongs to the UbiX/PAD1 family. | Lysine-arginine-ornithine-binding periplasmic protein; COG: COG0834; Pfam: PF00497; InterPro: IPR005768; Belongs to the bacterial solute-binding protein 3 family. | 0.405 |
| ubiX | purF | HMPREF0758_2763 | HMPREF0758_2762 | Polyprenyl P-hydroxybenzoate and phenylacrylic acid decarboxylase; Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3-polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN; Belongs to the UbiX/PAD1 family. | Amidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine; In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family. | 0.534 |
| ubiX | ubiA | HMPREF0758_2763 | HMPREF0758_1705 | Polyprenyl P-hydroxybenzoate and phenylacrylic acid decarboxylase; Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3-polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN; Belongs to the UbiX/PAD1 family. | 4-hydroxybenzoate polyprenyl transferase; Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3-octaprenyl-4-hydroxybenzoate. | 0.951 |
| ubiX | ubiD | HMPREF0758_2763 | HMPREF0758_1642 | Polyprenyl P-hydroxybenzoate and phenylacrylic acid decarboxylase; Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3-polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN; Belongs to the UbiX/PAD1 family. | UbiD family decarboxylase; Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol, an intermediate step in ubiquinone biosynthesis. | 0.993 |
| ubiX | ubiF | HMPREF0758_2763 | HMPREF0758_2213 | Polyprenyl P-hydroxybenzoate and phenylacrylic acid decarboxylase; Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3-polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN; Belongs to the UbiX/PAD1 family. | Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; COG: COG0654; Pfam: PF01266; InterPro: IPR010971. | 0.912 |