| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| TyrP_1 | putA | HMPREF0758_1917 | HMPREF0758_3240 | Transmembrane amino acid transporter protein; COG: COG0814; Pfam: PF01490. | Delta-1-pyrroline-5-carboxylate dehydrogenase; Oxidizes proline to glutamate for use as a carbon and nitrogen source; Belongs to the aldehyde dehydrogenase family. In the N-terminal section; belongs to the proline dehydrogenase family. | 0.438 |
| TyrP_1 | tnaB | HMPREF0758_1917 | HMPREF0758_2881 | Transmembrane amino acid transporter protein; COG: COG0814; Pfam: PF01490. | Aromatic amino acid transport protein; COG: COG0814; Pfam: PF03222; InterPro: IPR002091. | 0.498 |
| menC | tnaB | HMPREF0758_2820 | HMPREF0758_2881 | O-succinylbenzoate synthase; Converts 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1- carboxylate (SHCHC) to 2-succinylbenzoate (OSB). | Aromatic amino acid transport protein; COG: COG0814; Pfam: PF03222; InterPro: IPR002091. | 0.485 |
| menC | trpR | HMPREF0758_2820 | HMPREF0758_0599 | O-succinylbenzoate synthase; Converts 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1- carboxylate (SHCHC) to 2-succinylbenzoate (OSB). | Trp operon repressor; This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region. | 0.401 |
| menC | yfbU | HMPREF0758_2820 | HMPREF0758_2782 | O-succinylbenzoate synthase; Converts 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1- carboxylate (SHCHC) to 2-succinylbenzoate (OSB). | YfbU domain protein; COG: COG3013; Pfam: PF03887; InterPro: IPR005587; Belongs to the UPF0304 family. | 0.672 |
| putA | TyrP_1 | HMPREF0758_3240 | HMPREF0758_1917 | Delta-1-pyrroline-5-carboxylate dehydrogenase; Oxidizes proline to glutamate for use as a carbon and nitrogen source; Belongs to the aldehyde dehydrogenase family. In the N-terminal section; belongs to the proline dehydrogenase family. | Transmembrane amino acid transporter protein; COG: COG0814; Pfam: PF01490. | 0.438 |
| putA | stp-2 | HMPREF0758_3240 | HMPREF0758_3988 | Delta-1-pyrroline-5-carboxylate dehydrogenase; Oxidizes proline to glutamate for use as a carbon and nitrogen source; Belongs to the aldehyde dehydrogenase family. In the N-terminal section; belongs to the proline dehydrogenase family. | Serine transporter; COG: COG0814. | 0.438 |
| putA | stp-3 | HMPREF0758_3240 | HMPREF0758_4522 | Delta-1-pyrroline-5-carboxylate dehydrogenase; Oxidizes proline to glutamate for use as a carbon and nitrogen source; Belongs to the aldehyde dehydrogenase family. In the N-terminal section; belongs to the proline dehydrogenase family. | Serine transporter; COG: COG0814; InterPro: IPR004694. | 0.438 |
| putA | tnaB | HMPREF0758_3240 | HMPREF0758_2881 | Delta-1-pyrroline-5-carboxylate dehydrogenase; Oxidizes proline to glutamate for use as a carbon and nitrogen source; Belongs to the aldehyde dehydrogenase family. In the N-terminal section; belongs to the proline dehydrogenase family. | Aromatic amino acid transport protein; COG: COG0814; Pfam: PF03222; InterPro: IPR002091. | 0.438 |
| stp-2 | putA | HMPREF0758_3988 | HMPREF0758_3240 | Serine transporter; COG: COG0814. | Delta-1-pyrroline-5-carboxylate dehydrogenase; Oxidizes proline to glutamate for use as a carbon and nitrogen source; Belongs to the aldehyde dehydrogenase family. In the N-terminal section; belongs to the proline dehydrogenase family. | 0.438 |
| stp-2 | tnaB | HMPREF0758_3988 | HMPREF0758_2881 | Serine transporter; COG: COG0814. | Aromatic amino acid transport protein; COG: COG0814; Pfam: PF03222; InterPro: IPR002091. | 0.442 |
| stp-3 | putA | HMPREF0758_4522 | HMPREF0758_3240 | Serine transporter; COG: COG0814; InterPro: IPR004694. | Delta-1-pyrroline-5-carboxylate dehydrogenase; Oxidizes proline to glutamate for use as a carbon and nitrogen source; Belongs to the aldehyde dehydrogenase family. In the N-terminal section; belongs to the proline dehydrogenase family. | 0.438 |
| stp-3 | tnaB | HMPREF0758_4522 | HMPREF0758_2881 | Serine transporter; COG: COG0814; InterPro: IPR004694. | Aromatic amino acid transport protein; COG: COG0814; Pfam: PF03222; InterPro: IPR002091. | 0.454 |
| tnaA | tnaB | HMPREF0758_0714 | HMPREF0758_2881 | Tryptophan 2,3-dioxygenase; COG: COG3033; Pfam: PF01212; InterPro: IPR013440; Belongs to the beta-eliminating lyase family. | Aromatic amino acid transport protein; COG: COG0814; Pfam: PF03222; InterPro: IPR002091. | 0.426 |
| tnaB | TyrP_1 | HMPREF0758_2881 | HMPREF0758_1917 | Aromatic amino acid transport protein; COG: COG0814; Pfam: PF03222; InterPro: IPR002091. | Transmembrane amino acid transporter protein; COG: COG0814; Pfam: PF01490. | 0.498 |
| tnaB | menC | HMPREF0758_2881 | HMPREF0758_2820 | Aromatic amino acid transport protein; COG: COG0814; Pfam: PF03222; InterPro: IPR002091. | O-succinylbenzoate synthase; Converts 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1- carboxylate (SHCHC) to 2-succinylbenzoate (OSB). | 0.485 |
| tnaB | putA | HMPREF0758_2881 | HMPREF0758_3240 | Aromatic amino acid transport protein; COG: COG0814; Pfam: PF03222; InterPro: IPR002091. | Delta-1-pyrroline-5-carboxylate dehydrogenase; Oxidizes proline to glutamate for use as a carbon and nitrogen source; Belongs to the aldehyde dehydrogenase family. In the N-terminal section; belongs to the proline dehydrogenase family. | 0.438 |
| tnaB | stp-2 | HMPREF0758_2881 | HMPREF0758_3988 | Aromatic amino acid transport protein; COG: COG0814; Pfam: PF03222; InterPro: IPR002091. | Serine transporter; COG: COG0814. | 0.442 |
| tnaB | stp-3 | HMPREF0758_2881 | HMPREF0758_4522 | Aromatic amino acid transport protein; COG: COG0814; Pfam: PF03222; InterPro: IPR002091. | Serine transporter; COG: COG0814; InterPro: IPR004694. | 0.454 |
| tnaB | tnaA | HMPREF0758_2881 | HMPREF0758_0714 | Aromatic amino acid transport protein; COG: COG0814; Pfam: PF03222; InterPro: IPR002091. | Tryptophan 2,3-dioxygenase; COG: COG3033; Pfam: PF01212; InterPro: IPR013440; Belongs to the beta-eliminating lyase family. | 0.426 |